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Plasma levels of the chemokines monocyte chemotactic proteins-1 and -2 are
elevated in human sepsis
AW Bossink, L Paemen, PM Jansen, CE Hack, LG Thijs and J Van Damme
Department of Internal Medicine, Free University Hospital, Amsterdam, The
Netherlands.
Because of their effects on monocytes, monocyte chemotactic proteins-1 and
-2 (MCP-1 and MCP-2) may participate in the pathophysiology of sepsis. We
measured circulating MCP-1 and MCP-2 levels in 42 septic patients having
positive local or blood cultures. MCP-1 and MCP-2 levels were elevated in
24 (57%) and 25 (59%) of 42 septic patients, respectively, compared with
healthy volunteers. Both patients with gram- positive and gram-negative
infections had elevated MCP-1 plasma levels (P = .0001) and P < .0001),
respectively; Mann-Whitney-U test), whereas patients with gram-positive
infection, but not those with gram-negative infection, had increased MCP-2
plasma levels (P= .0182). No relative differences in MCP-1 and MCP-2 plasma
levels were observed between several subgroups of patients (sepsis v septic
shock; survivors v nonsurvivors), although levels of MCP-1 were the highest
in patients with the more severe forms of sepsis, ie, those with shock or a
lethal outcome. Serial observations showed that MCP-1 and MCP-2 plasma
levels remained elevated for at least 48 hours. MCP-1 correlated weakly
with interleukin-8 and MCP-2, the correlations for which were most
pronounced in patients with septic shock. MCP-2 correlated with
interleukin-8, and surprisingly, with the complement activation product
C3a; these correlations further improved when analyzing patients with
septic shock or when applying gram-positive infections. Thus, our results
not only show increased MCP-1 and MCP-2 levels in patients with sepsis, but
also suggest that the synthesis and release of MCP-1 and MCP-2 in sepsis
are differently regulated in part.
Volume 86,
Issue 10,
pp. 3841-3847,
11/15/1995
Copyright © 1995 by The American Society of Hematology
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