|
|
 Previous Article | Table of Contents | Next Article 
Salicylates inhibit lipopolysaccharide-induced transcriptional activation
of the tissue factor gene in human monocytic cells
P Oeth and N Mackman
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037,
USA.
Binding of plasma Factor VII/VIIa to the tissue factor (TF) receptor
initiates the coagulation protease cascades. TF expression by circulating
monocytes is associated with thrombotic and inflammatory complications in a
variety of diseases. Transcriptional activation of the human TF gene in
monocytic cells exposed to bacterial lipopolysaccharide (LPS) is mediated
by binding of c-Rel/p65 heterodimers to a kappa B site in the TF promoter.
Here, we report that a family of anti-inflammatory agents, known as the
salicylates, inhibited LPS induction of TF activity and TF gene
transcription in human monocytes and monocytic THP-1 cells at clinically
relevant doses. Furthermore, sodium salicylate blocked the LPS-induced
proteolytic degradation of I kappa B alpha, which prevented the nuclear
translocation of c-Rel/p65 heterodimers. In contrast, two other
nonsteroidal anti-inflammatory drugs, ibuprofen and indomethacin, did not
inhibit LPS induction of the TF gene. These results indicated that
salicylates inhibited LPS induction of TF gene transcription in monocytic
cells by preventing nuclear translocation of c-Rel/p65 heterodimers. The
clinical benefits of salicylates in the treatment of several diseases,
including atherosclerosis and rheumatoid arthritis, may be related to their
ability to reduce monocyte gene expression.
Volume 86,
Issue 11,
pp. 4144-4152,
12/01/1995
Copyright © 1995 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
J. Wang, S. A. Mahmud, P. B. Bitterman, Y. Huo, and A. Slungaard
Histone Deacetylase Inhibitors Suppress TF-{kappa}B-dependent Agonist-driven Tissue Factor Expression in Endothelial Cells and Monocytes
J. Biol. Chem.,
September 28, 2007;
282(39):
28408 - 28418.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. V. Tsytsykova, J. V. Falvo, M. Schmidt-Supprian, G. Courtois, D. Thanos, and A. E. Goldfeld
Post-induction, Stimulus-specific Regulation of Tumor Necrosis Factor mRNA Expression
J. Biol. Chem.,
April 20, 2007;
282(16):
11629 - 11638.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Cai, C. Song, I. Endoh, J. Goyette, W. Jessup, S. B. Freedman, H. P. McNeil, and C. L. Geczy
Serum Amyloid A Induces Monocyte Tissue Factor
J. Immunol.,
February 1, 2007;
178(3):
1852 - 1860.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Planavila, R. Rodriguez-Calvo, A. F. de Arriba, R. M. Sanchez, J. C. Laguna, M. Merlos, and M. Vazquez-Carrera
Inhibition of Cardiac Hypertrophy by Triflusal (4-Trifluoromethyl Derivative of Salicylate) and Its Active Metabolite
Mol. Pharmacol.,
April 1, 2006;
69(4):
1174 - 1181.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. D. Dwyer-Nield, M. C. Srebernak, B. S. Barrett, J. Ahn, P. Cosper, A. M. Meyer, L. R. Kisley, A. K. Bauer, D. C. Thompson, and A. M. Malkinson
Cytokines differentially regulate the synthesis of prostanoid and nitric oxide mediators in tumorigenic versus non-tumorigenic mouse lung epithelial cell lines
Carcinogenesis,
July 1, 2005;
26(7):
1196 - 1206.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Sanguigni, D. Ferro, P. Pignatelli, M. Del Ben, T. Nadia, M. Saliola, R. Sorge, and F. Violi
CD40 ligand enhances monocyte tissue factor expression and thrombin generation via oxidative stress in patients with hypercholesterolemia
J. Am. Coll. Cardiol.,
January 4, 2005;
45(1):
35 - 42.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Marsik, M. Graninger, N. Mackman, B. Osterud, T. Luther, and B. Jilma
Effects of enalapril on disseminated intravascular thrombin formation during systemic inflammation
Cardiovasc Res,
October 15, 2003;
60(1):
131 - 135.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Tamura, S. Sebastian, S. Yang, B. Gurates, Z. Fang, and S. E. Bulun
Interleukin-1{beta} Elevates Cyclooxygenase-2 Protein Level and Enzyme Activity via Increasing Its mRNA Stability in Human Endometrial Stromal Cells: An Effect Mediated by Extracellularly Regulated Kinases 1 and 2
J. Clin. Endocrinol. Metab.,
July 1, 2002;
87(7):
3263 - 3273.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Wright, I. S. Singh, J. D. Hasday, I. K. Farrance, G. Hall, A. S. Cross, and T. B. Rogers
Endotoxin stress-response in cardiomyocytes: NF-kappa B activation and tumor necrosis factor-alpha expression
Am J Physiol Heart Circ Physiol,
March 1, 2002;
282(3):
H872 - H879.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. TEGEDER, J. PFEILSCHIFTER, and G. GEISSLINGER
Cyclooxygenase-independent actions of cyclooxygenase inhibitors
FASEB J,
October 1, 2001;
15(12):
2057 - 2072.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-L. Liao, Y.-L. Lin, B.-C. Wu, C.-H. Tsao, M.-C. Wang, C.-I Liu, Y.-L. Huang, J.-H. Chen, J.-P. Wang, and L.-K. Chen
Salicylates Inhibit Flavivirus Replication Independently of Blocking Nuclear Factor Kappa B Activation
J. Virol.,
September 1, 2001;
75(17):
7828 - 7839.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-G. Yoo, S. Lee, C.-T. Lee, Y. W. Kim, S. K. Han, and Y.-S. Shim
Effect of acetylsalicylic acid on endogenous I{kappa}B kinase activity in lung epithelial cells
Am J Physiol Lung Cell Mol Physiol,
January 1, 2001;
280(1):
L3 - L9.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Alpert and J. Vilcek
Inhibition of Ikappa B Kinase Activity by Sodium Salicylate in Vitro Does Not Reflect Its Inhibitory Mechanism in Intact Cells
J. Biol. Chem.,
April 14, 2000;
275(15):
10925 - 10929.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Abraham
Coagulation Abnormalities in Acute Lung Injury and Sepsis
Am. J. Respir. Cell Mol. Biol.,
April 1, 2000;
22(4):
401 - 404.
[Full Text]
|
|
|
|
|
|
|
S. Hoshi, M. Goto, N. Koyama, K.-i. Nomoto, and H. Tanaka
Regulation of Vascular Smooth Muscle Cell Proliferation by Nuclear Factor-kappa B and Its Inhibitor, I-kappa B
J. Biol. Chem.,
January 14, 2000;
275(2):
883 - 889.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Alpert, P. Schwenger, and J. Han
Cell Stress and MKK6b-mediated p38 MAP Kinase Activation Inhibit Tumor Necrosis Factor-induced Ikappa B Phosphorylation and NF-kappa B Activation
J. Biol. Chem.,
August 6, 1999;
274(32):
22176 - 22183.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. N. Cronstein, M. C. Montesinos, and G. Weissmann
Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappa B
PNAS,
May 25, 1999;
96(11):
6377 - 6381.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Pratico, D. Ferro, L. Iuliano, J. Rokach, F. Conti, G. Valesini, G. A. FitzGerald, and F. Violi
Ongoing Prothrombotic State in Patients With Antiphospholipid Antibodies: A Role for Increased Lipid Peroxidation
Blood,
May 15, 1999;
93(10):
3401 - 3407.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Ferro, S. Basili, D. Pratico, L. Iuliano, G. A. FitzGerald, and F. Violi
Vitamin E Reduces Monocyte Tissue Factor Expression in Cirrhotic Patients
Blood,
May 1, 1999;
93(9):
2945 - 2950.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S SCHREIBER;
Activation of nuclear factor kappa B as a target for anti- inflammatory therapy
Gut,
March 1, 1999;
44(3):
309 - 310.
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. R. Pendurthi, J. T. Williams, and L. V. M. Rao
Resveratrol, a Polyphenolic Compound Found in Wine, Inhibits Tissue Factor Expression in Vascular Cells : A Possible Mechanism for the Cardiovascular Benefits Associated With Moderate Consumption of Wine
Arterioscler Thromb Vasc Biol,
February 1, 1999;
19(2):
419 - 426.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R M SCHMID, G ADLER, S LIPTAY, S SCHREIBER, S NIKOLAUS, and J HAMPE
Activation of NFkappa B in inflammatory bowel disease • Reply
Gut,
October 1, 1998;
43(4):
586c - 586.
[Full Text]
|
|
|
|
|
|
|
R. Sakiri, B. Ramegowda, and V. L. Tesh
Shiga Toxin Type 1 Activates Tumor Necrosis Factor-alpha Gene Transcription and Nuclear Translocation of the Transcriptional Activators Nuclear Factor-kappa B and Activator Protein-1
Blood,
July 15, 1998;
92(2):
558 - 566.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Oeth, J. Yao, S.-T. Fan, and N. Mackman
Retinoic Acid Selectively Inhibits Lipopolysaccharide Induction of Tissue Factor Gene Expression in Human Monocytes
Blood,
April 15, 1998;
91(8):
2857 - 2865.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Schwenger, D. Alpert, and E. Y. Skolnik
Activation of p38 Mitogen-Activated Protein Kinase by Sodium Salicylate Leads to Inhibition of Tumor Necrosis Factor-Induced Ikappa Balpha Phosphorylation and Degradation
Mol. Cell. Biol.,
January 1, 1998;
18(1):
78 - 84.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
U. R. Pendurthi, J. T. Williams, and L. V. M. Rao
Inhibition of Tissue Factor Gene Activation in Cultured Endothelial Cells by Curcumin : Suppression of Activation of Transcription Factors Egr-1, AP-1, and NF-{kappa}B
Arterioscler Thromb Vasc Biol,
December 1, 1997;
17(12):
3406 - 3413.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. E. Shackelford, P. B. Alford, Y. Xue, S.-F. Thai, D. O. Adams, and S. Pizzo
Aspirin Inhibits Tumor Necrosis Factor-alpha Gene Expression in Murine Tissue Macrophages
Mol. Pharmacol.,
September 1, 1997;
52(3):
421 - 429.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J. Yao, N. Mackman, T. S. Edgington, and S.-T. Fan
Lipopolysaccharide Induction of the Tumor Necrosis Factor-alpha Promoter in Human Monocytic Cells. REGULATION BY Egr-1, c-Jun, AND NF-kappa B TRANSCRIPTION FACTORS
J. Biol. Chem.,
July 11, 1997;
272(28):
17795 - 17801.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Oeth, G. C.N. Parry, and N. Mackman
Regulation of the Tissue Factor Gene in Human Monocytic Cells: Role of AP-1, NF-{kappa}B/Rel, and Sp1 Proteins in Uninduced and Lipopolysaccharide-Induced Expression
Arterioscler Thromb Vasc Biol,
February 1, 1997;
17(2):
365 - 374.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
V. Ollivier, G. C.N. Parry, R. R. Cobb, D. d. Prost, and N. Mackman
Elevated Cyclic AMP Inhibits NF-kappa B-mediated Transcription in Human Monocytic Cells and Endothelial Cells
J. Biol. Chem.,
August 23, 1996;
271(34):
20828 - 20835.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Silva and L. F. L. Reis
Sodium Salicylate Induces the Expression of the Immunophilin FKBP51 and Biglycan Genes and Inhibits p34cdc2 mRNA Both in Vitro and in Vivo
J. Biol. Chem.,
November 10, 2000;
275(46):
36388 - 36393.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
