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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Williams, M. Articles by Kelsey, S. Search for Related Content PubMed PubMed Citation Articles by Williams, M. Articles by Kelsey, S. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Administration of recombinant human granulocyte-macrophage colony- stimulating factor after chemotherapy regulates the expression and secretion of monocyte tumor necrosis factor (TNF) and TNF receptors p55 and p75 MA Williams, I Kouroumoussis, D Syndercombe-Court, L Hendry, AC Newland and SM Kelsey Department of Haematology, London Hospital Medical College, Whitechapel, UK. Monocyte expression and secretion of tumor necrosis factor (TNF) and TNF receptors (TNF-R) p55 and p75 was studied in patients receiving granulocyte-macrophage colony-stimulating factor (GM-CSF) after intensive chemotherapy. TNF expression and secretion of biologically active TNF was increased at regeneration compared with that of patients who had received chemotherapy alone. This effect persisted for several weeks after cessation of growth factor therapy. GM-CSF restored the responsiveness of monocytes to bacterial lipopolysaccharide (LPS), which appeared to be diminished after chemotherapy alone. Expression and secretion of TNF-R p55 and p75 by monocytes was augmented by GM-CSF therapy in association with the increase in TNF protein. We propose that GM-CSF administration after chemotherapy restores the normal responsiveness of monocytes to a secondary stimulus such as LPS and primes monocytes to respond to LPS with increased expression and secretion of TNF and TNF-R. Volume 86, Issue 11, pp. 4234-4242, 12/01/1995 Copyright © 1995 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. Dai, J. Guzman, B. Chen, and U. Costabel Production of Soluble Tumor Necrosis Factor Receptors and Tumor Necrosis Factor-{alpha} by Alveolar Macrophages in Sarcoidosis and Extrinsic Allergic Alveolitis Chest, January 1, 2005; 127(1): 251 - 256. [Abstract] [Full Text] [PDF]

	Copyright © 1995 by American Society of Hematology         Online ISSN: 1528-0020