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High frequency of t(12;21) in childhood B-lineage acute lymphoblastic
leukemia
SP Romana, H Poirel, M Leconiat, MA Flexor, M Mauchauffe, P Jonveaux, EA Macintyre, R Berger and OA Bernard
U301 de l'Institut National de la Sante et de la Recherche Medicale, Paris,
France.
The recurrent t(12;21)(p12;q22) translocation fuses two genes, TEL and
AML1, that have previously been shown to be independently involved in
myeloid malignant proliferations. A search for rearrangement of the TEL
locus in the region known to be involved in t(12;21) was performed by
Southern blotting in a panel of hematopoietic malignancies. The presence of
a t(12;21) was confirmed by fluorescence in situ hybridization (FISH)
and/or reverse transcriptase (RT)-polymerase chain reaction (PCR). We
report that fusion of TEL to AML1 is specifically observed in at least 16%
of the childhood B-lineage acute lymphoblastic leukemia (ALL) investigated,
none of which had been previously identified as harboring t(12;21).
Volume 86,
Issue 11,
pp. 4263-4269,
12/01/1995
Copyright © 1995 by The American Society of Hematology
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