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Leukemia translocation gene, PLZF, is expressed with a speckled nuclear
pattern in early hematopoietic progenitors
A Reid, A Gould, N Brand, M Cook, P Strutt, J Li, J Licht, S Waxman, R Krumlauf and A Zelent
Leukaemia Research Fund Centre at the Institute of Cancer Research, London,
UK.
The PLZF gene was discovered by studying a rearrangement of the RAR alpha
locus in a patient with acute promyelocytic leukemia and a t(11;17)
chromosomal translocation. To understand further the potential role(s) of
the PLZF gene product in hematopoiesis, we have examined its expression
levels in a variety of murine tissues and in established cell lines that
are representative of various stages of myeloid and lymphoid development.
We show that murine PLZF(mPLZF) is expressed at the highest levels in
undifferentiated, multipotential hematopoietic progenitor cells and that
its expression declines as cells become more mature and committed to
various hematopoietic lineages. Data obtained with established cell lines
are corroborated by results showing the lack of human PLZF protein
expression in mature peripheral blood mononuclear cells and high PLZF
levels in the nuclei of CD34+ human bone marrow progenitor cells.
Interestingly, unlike many transcription factors, PLZF protein in these
cells possesses distinct punctate nuclear distribution, suggesting its
compartmentalization in the nucleus. Taken together, our data suggest a
role for PLZF protein in early hematopoiesis and the requirement of
downregulation of its expression for proper differentiation of most
hematopoietic lineages.
Volume 86,
Issue 12,
pp. 4544-4552,
12/15/1995
Copyright © 1995 by The American Society of Hematology
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