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Apoptosis of human hematopoietic progenitor cells induced by crosslinking
of surface CD43, the major sialoglycoprotein of leukocytes
V Bazil, J Brandt, A Tsukamoto and R Hoffman
Research Department, SyStemix Inc, Palo Alto, CA 94304, USA.
Interactions of hematopoietic progenitor cells (HPC) with bone marrow
stroma, mediated by adhesion molecules, are assumed to be critically
important to the regulation of hematopoiesis. However, the specific roles
of individual adhesion molecules involved in these interactions are poorly
understood. Here, a monoclonal antibody, MEM-59, recognizing CD43, an
adhesion molecule highly expressed on HPC, is shown to induce apoptosis in
this cell population. This process operates at the single- cell level, and
its initiation requires crosslinking of surface CD43 and the presence of
cytokines. In contrast to HPC, more differentiated cells originating from
this primitive cell population, as well as peripheral lymphocytes, do not
undergo apoptosis in response to the CD43-mediated stimulation. Thus, CD43
may function as a negative regulator of early hematopoietic events,
delivering a signal for apoptosis of HPC.
Volume 86,
Issue 2,
pp. 502-511,
07/15/1995
Copyright © 1995 by The American Society of Hematology
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