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Long-term human hematopoiesis in SCID-hu mice bearing transplanted
fragments of adult bone and bone marrow cells
Y Heike, T Ohira, M Takahashi and N Saijo
Pharmacology Division, National Cancer Center Research Institute, Tokyo,
Japan.
An attempt was made to establish an SCID-hu murine model of long-term human
hematopoiesis by coimplantation of a bone fragment and bone marrow (BM)
cells from an adult human. The SCID-hu mice were treated with a cytokine
mixture (recombinant human stem cell factor, interleukin-3,
granulocyte/macrophage colony-stimulating factor, and granulocyte
colony-stimulating factor) for 4 months and were then maintained for
further 8 months under cytokine-free conditions. In the peripheral blood,
spleen, and implanted bone fragments in the SCID-hu mice that had received
both a bone fragment and BM cells, human CD59+ cells were detected 1 year
after transplantation; however, they were not detectable in SCID-hu mice
that had received either a bone fragment or BM cells only. Thus,
implantation of both a bone fragment and BM cells appears to provide a
model of long-term adult human hematopoiesis in SCID mice.
Volume 86,
Issue 2,
pp. 524-530,
07/15/1995
Copyright © 1995 by The American Society of Hematology
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