|
|
 Previous Article | Table of Contents | Next Article 
Murine hematopoietic progenitors are capable of both histamine synthesis
and uptake
S Corbel, E Schneider, FM Lemoine and M Dy
Universite Rene Descartes-Paris V, CNRS URA 1461, Hopital Necker, Paris,
France.
We examined various murine hematopoietic cell populations for their
capacity to interact with radiolabeled histamine. Only bone marrow cells
(BMC) retained substantial amounts of radioactivity, in contrast to thymus,
spleen, and peritoneal cells. The characteristics of this interaction are
consistent with histamine uptake rather than receptor binding. Indeed, this
process is temperature and sodium dependent and reduced by various
metabolic inhibitors. Furthermore, the effect of antagonists or agonists of
the H1, H2, and H3 receptor subtypes is not in accordance with the
involvement of either of these receptors in histamine binding. The target
cells of histamine copurify with hematopoietic progenitors in the
low-density BM population. They are most enriched in the subset sorted from
the blast cell window on the basis of high rhodamine retention. This
fraction contains on the average 80% to 90% immature cells and is highly
enriched for several clonogenic progenitor subsets. Sixty percent of the
Rh-bright cells are labeled by 3H-histamine, as assessed by
autoradiography, suggesting that a variety of immature cells participates
in this phenomenon. Furthermore, in all sorting procedures used here, the
cells capable of histamine uptake coenrich with those producing histamine
in response to interleukin-3, indicating at least a partial identity
between these cells.
Volume 86,
Issue 2,
pp. 531-539,
07/15/1995
Copyright © 1995 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
M. Biosse-Duplan, B. Baroukh, M. Dy, M.-C. de Vernejoul, and J.-L. Saffar
Histamine Promotes Osteoclastogenesis through the Differential Expression of Histamine Receptors on Osteoclasts and Osteoblasts
Am. J. Pathol.,
April 1, 2009;
174(4):
1426 - 1434.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Schneider, F. Machavoine, J.-M. Pleau, A.-F. Bertron, R. L. Thurmond, H. Ohtsu, T. Watanabe, A. H. Schinkel, and M. Dy
Organic cation transporter 3 modulates murine basophil functions by controlling intracellular histamine levels
J. Exp. Med.,
August 1, 2005;
202(3):
387 - 393.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Tanaka, K. Deai, M. Inagaki, and A. Ichikawa
Uptake of histamine by mouse peritoneal macrophages and a macrophage cell line, RAW264.7
Am J Physiol Cell Physiol,
September 1, 2003;
285(3):
C592 - C598.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Tanaka, K.-i. Nemoto, E. Yamamura, and A. Ichikawa
Intracellular Localization of the 74- and 53-kDa Forms of L-Histidine Decarboxylase in a Rat Basophilic/Mast Cell Line, RBL-2H3
J. Biol. Chem.,
April 3, 1998;
273(14):
8177 - 8182.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
