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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hayes, M. Articles by Norcross, M. Search for Related Content PubMed PubMed Citation Articles by Hayes, M. Articles by Norcross, M. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes MP Hayes, J Wang and MA Norcross Division of Cytokine Biology, Food and Drug Administration, Bethesda, MD 20892, USA. Interleukin-12 (IL-12) is a monocyte/macrophage-derived cytokine that is critical for T lymphocyte and natural killer cell activities and functions. In this study, we examined the regulation of IL-12 expression by human monocytes in response to bacterial lipopolysaccharide (LPS). Several novel aspects of IL-12 induction from monocytes were shown. Optimal expression of IL-12 mRNA and bioactivity required specific priming of monocytes by interferon-gamma (IFN-gamma) before LPS stimulation. Granulocyte-macrophage colony-stimulating factor (GM-CSF) provided an equivalent priming stimulus for LPS-induced tumor necrosis factor (TNF) and IL-12 p40 mRNA, but primed poorly for LPS-inducible p35 message and secreted IL-12 activity. Macrophage colony-stimulating factor (M-CSF), although a potent survival factor for monocytes, showed no priming activity for IL-12 production. Time course experiments demonstrated independent regulation of p40 and p35 by IFN-gamma and LPS. LPS inducibility of p40 expression required only a brief exposure to IFN-gamma (2 hours), while prolonged exposure (+/- 24 hours) to IFN-gamma resulted in diminishing levels of p40 mRNA. p35 inducibility (by LPS) required a longer exposure to IFN-gamma (8 to 16 hours), and continued to be inducible up to 40 hours following IFN- gamma priming. Both mRNAs were rapidly induced (1 to 2 hours) in IFN- gamma-primed monocytes; p35 message reached a plateau by 2 hours, while p40 continued to accumulate. Finally, both p40 and p35 were directly induced by LPS in the presence of cycloheximide. These results indicated that both p40 and p35 are LPS-inducible in monocytes following IFN-gamma pretreatment, and that the regulated expression of p35 controls the level of active IL-12 protein in purified human monocytes. The selectivity of priming by IFN-gamma is in accord with a putative role for IL-12 in the initiation and amplification of TH1-type responses. Volume 86, Issue 2, pp. 646-650, 07/15/1995 Copyright © 1995 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. van de Wetering, R. A. de Paus, J. T. van Dissel, and E. van de Vosse IL-23 modulates CD56+/CD3- NK Cell and CD56+/CD3+ NK-like T Cell function differentially from IL-12 Int. Immunol., February 1, 2009; 21(2): 145 - 153. [Abstract] [Full Text] [PDF] F. Gerosa, B. Baldani-Guerra, L. A. Lyakh, G. Batoni, S. Esin, R. T. Winkler-Pickett, M. R. Consolaro, M. De Marchi, D. Giachino, A. Robbiano, et al. Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells J. Exp. Med., June 9, 2008; 205(6): 1447 - 1461. [Abstract] [Full Text] [PDF] D. Santoni, M. Pedicini, and F. 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Iizuka, J. Hamuro, T. Nakazawa, and M. Mori Glutathione redox regulates lipopolysaccharide-induced IL-12 production through p38 mitogen-activated protein kinase activation in human monocytes: role of glutathione redox in IFN-{gamma} priming of IL-12 production J. Leukoc. Biol., February 1, 2002; 71(2): 339 - 347. [Abstract] [Full Text] [PDF] C. J. Godshall, A. B. Lentsch, J. C. Peyton, M. J. Scott, and W. G. Cheadle STAT4 Is Required for Antibacterial Defense but Enhances Mortality during Polymicrobial Sepsis Clin. Vaccine Immunol., November 1, 2001; 8(6): 1044 - 1048. [Abstract] [Full Text] [PDF] R. Grumont, H. Hochrein, M. O'Keeffe, R. Gugasyan, C. White, I. Caminschi, W. Cook, and S. Gerondakis C-Rel Regulates Interleukin 12 P70 Expression in Cd8+ Dendritic Cells by Specifically Inducing p35 Gene Transcription J. Exp. Med., October 15, 2001; 194(8): 1021 - 1032. [Abstract] [Full Text] [PDF] A. E. Morelli, A. F. Zahorchak, A. T. Larregina, B. L. Colvin, A. J. Logar, T. Takayama, L. D. Falo, and A. W. Thomson Cytokine production by mouse myeloid dendritic cells in relation to differentiation and terminal maturation induced by lipopolysaccharide or CD40 ligation Blood, September 1, 2001; 98(5): 1512 - 1523. [Abstract] [Full Text] [PDF] R. Brewington, M. Chatterji, M. Zoubine, R. N. Miranda, M. Norimatsu, and A. Shnyra IFN-{{gamma}}-Independent Autocrine Cytokine Regulatory Mechanism in Reprogramming of Macrophage Responses to Bacterial Lipopolysaccharide J. Immunol., July 1, 2001; 167(1): 392 - 398. [Abstract] [Full Text] [PDF] S. J. Till, L. A. Jopling, P. A. Wachholz, R. L. Robson, S. Qin, D. P. Andrew, L. Wu, J. van Neerven, T. J. Williams, S. R. Durham, et al. T Cell Phenotypes of the Normal Nasal Mucosa: Induction of Th2 Cytokines and CCR3 Expression by IL-4 J. Immunol., February 15, 2001; 166(4): 2303 - 2310. [Abstract] [Full Text] [PDF] S. Goriely, B. Vincart, P. Stordeur, J. Vekemans, F. Willems, M. Goldman, and D. De Wit Deficient IL-12(p35) Gene Expression by Dendritic Cells Derived from Neonatal Monocytes J. Immunol., February 1, 2001; 166(3): 2141 - 2146. [Abstract] [Full Text] [PDF] M.A. Taubman and T. Kawai Involvement of T-Lymphocytes in Periodontal Disease and in Direct and Indirect Induction of Bone Resorption Critical Reviews in Oral Biology & Medicine, January 1, 2001; 12(2): 125 - 135. [Abstract] [Full Text] [PDF] M. I. Garcia-Lloret, B. Winkler-Lowen, and L. J. Guilbert Monocytes adhering by LFA-1 to placental syncytiotrophoblasts induce local apoptosis via release of TNF-{alpha}. A model for hematogenous initiation of placental inflammations J. Leukoc. Biol., December 1, 2000; 68(6): 903 - 908. [Abstract] [Full Text] L. Malmgaard, S. R. Paludan, S. C. Mogensen, and S. Ellermann-Eriksen Herpes simplex virus type 2 induces secretion of IL-12 by macrophages through a mechanism involving NF-{kappa}B J. Gen. Virol., December 1, 2000; 81(12): 3011 - 3020. [Abstract] [Full Text] A. Boonstra, A. van Oudenaren, B. Barendregt, L. An, P. J. M. Leenen, and H. F. J. Savelkoul UVB irradiation modulates systemic immune responses by affecting cytokine production of antigen-presenting cells Int. Immunol., November 1, 2000; 12(11): 1531 - 1538. [Abstract] [Full Text] [PDF] A. W. O’Regan, J. M Hayden, and J. S. Berman Osteopontin augments CD3-mediated interferon-{gamma} and CD40 ligand expression by T cells, which results in IL-12 production from peripheral blood mononuclear cells J. Leukoc. Biol., October 1, 2000; 68(4): 495 - 502. [Abstract] [Full Text] M J Plummeridge, L Armstrong, M A Birchall, and A B Millar Reduced production of interleukin 12 by interferon gamma primed alveolar macrophages from atopic asthmatic subjects Thorax, October 1, 2000; 55(10): 842 - 847. [Abstract] [Full Text] H. Hochrein, M. O'Keeffe, T. Luft, S. Vandenabeele, R. J. Grumont, E. Maraskovsky, and K. Shortman Interleukin (Il)-4 Is a Major Regulatory Cytokine Governing Bioactive IL-12 Production by Mouse and Human Dendritic Cells J. Exp. Med., September 18, 2000; 192(6): 823 - 834. [Abstract] [Full Text] [PDF] M. J. Smyth, M. Taniguchi, and S. E. A. Street The Anti-Tumor Activity of IL-12: Mechanisms of Innate Immunity That Are Model and Dose Dependent J. Immunol., September 1, 2000; 165(5): 2665 - 2670. [Abstract] [Full Text] [PDF] S. Gurunathan, L. Stobie, C. Prussin, D. L. Sacks, N. Glaichenhaus, D. J. Fowell, R. M. Locksley, J. T. Chang, C.-Y. Wu, and R. A. Seder Requirements for the Maintenance of Th1 Immunity In Vivo Following DNA Vaccination: A Potential Immunoregulatory Role for CD8+ T Cells J. Immunol., July 15, 2000; 165(2): 915 - 924. [Abstract] [Full Text] [PDF] A. J. F. Luty, D. J. Perkins, B. Lell, R. Schmidt-Ott, L. G. Lehman, D. Luckner, B. Greve, P. Matousek, K. Herbich, D. Schmid, et al. Low Interleukin-12 Activity in Severe Plasmodium falciparum Malaria Infect. Immun., July 1, 2000; 68(7): 3909 - 3915. [Abstract] [Full Text] [PDF] I-M. Wang, C. Contursi, A. Masumi, X. Ma, G. Trinchieri, and K. Ozato An IFN-{gamma}-Inducible Transcription Factor, IFN Consensus Sequence Binding Protein (ICSBP), Stimulates IL-12 p40 Expression in Macrophages J. Immunol., July 1, 2000; 165(1): 271 - 279. [Abstract] [Full Text] [PDF] T. Kato and H. Nariuchi Polarization of Naive CD4+ T Cells Toward the Th1 Subset by CTLA-4 Costimulation J. Immunol., April 1, 2000; 164(7): 3554 - 3562. [Abstract] [Full Text] [PDF] M. C. Braun, E. Lahey, and B. L. Kelsall Selective Suppression of IL-12 Production by Chemoattractants J. Immunol., March 15, 2000; 164(6): 3009 - 3017. [Abstract] [Full Text] [PDF] F. J. Murphy, M. P. Hayes, and P. R. Burd Disparate Intracellular Processing of Human IL-12 Preprotein Subunits: Atypical Processing of the P35 Signal Peptide J. Immunol., January 15, 2000; 164(2): 839 - 847. [Abstract] [Full Text] [PDF] L.-Y. Huang, A. M. Krieg, N. Eller, and D. E. Scott Induction and Regulation of Th1-Inducing Cytokines by Bacterial DNA, Lipopolysaccharide, and Heat-Inactivated Bacteria Infect. Immun., December 1, 1999; 67(12): 6257 - 6263. [Abstract] [Full Text] [PDF] J. Wang, E. Guan, G. Roderiquez, and M. A. Norcross Inhibition of CCR5 Expression by IL-12 Through Induction of {beta}-Chemokines in Human T Lymphocytes J. Immunol., December 1, 1999; 163(11): 5763 - 5769. [Abstract] [Full Text] [PDF] D. L. Foss, M. J. Zilliox, and M. P. Murtaugh Differential Regulation of Macrophage Interleukin-1 (IL-1), IL-12, and CD80-CD86 by Two Bacterial Toxins Infect. Immun., October 1, 1999; 67(10): 5275 - 5281. [Abstract] [Full Text] [PDF] M. Wittmann, V.-A. Larsson, P. Schmidt, G. Begemann, A. Kapp, and T. Werfel Suppression of Interleukin-12 Production by Human Monocytes After Preincubation With Lipopolysaccharide Blood, September 1, 1999; 94(5): 1717 - 1726. [Abstract] [Full Text] [PDF] M. Watanabe, R. G. Fenton, J. M. Wigginton, K. L. McCormick, K. M. Volker, W. E. Fogler, P. G. Roessler, and R. H. Wiltrout Intradermal Delivery of IL-12 Naked DNA Induces Systemic NK Cell Activation and Th1 Response In Vivo That Is Independent of Endogenous IL-12 Production J. Immunol., August 15, 1999; 163(4): 1943 - 1950. [Abstract] [Full Text] [PDF] S. Mukhopadhyay, P. K. Sahoo, A. George, V. Bal, S. Rath, and B. Ravindran Delayed Clearance of Filarial Infection and Enhanced Th1 Immunity Due to Modulation of Macrophage APC Functions in xid Mice J. Immunol., July 15, 1999; 163(2): 875 - 883. [Abstract] [Full Text] [PDF] H. Yamane, T. Kato, and H. Nariuchi Effective Stimulation for IL-12 p35 mRNA Accumulation and Bioactive IL-12 Production of Antigen-Presenting Cells Interacted with Th Cells J. Immunol., June 1, 1999; 162(11): 6433 - 6441. [Abstract] [Full Text] [PDF] M. Wittmann, J. Zwirner, V.-A. Larsson, K. Kirchhoff, G. Begemann, A. Kapp, O. Gotze, and T. Werfel C5a Suppresses the Production of IL-12 by IFN-{gamma}-Primed and Lipopolysaccharide-Challenged Human Monocytes J. Immunol., June 1, 1999; 162(11): 6763 - 6769. [Abstract] [Full Text] [PDF] D. W. Mullins, C. J. Burger, and K. D. Elgert Paclitaxel Enhances Macrophage IL-12 Production in Tumor-Bearing Hosts Through Nitric Oxide J. Immunol., June 1, 1999; 162(11): 6811 - 6818. [Abstract] [Full Text] [PDF] M. K. Levings and J. W. Schrader IL-4 Inhibits the Production of TNF-{alpha} and IL-12 by STAT6-Dependent and -Independent Mechanisms J. Immunol., May 1, 1999; 162(9): 5224 - 5229. [Abstract] [Full Text] [PDF] J. M. Babik, E. Adams, Y. Tone, P. J. Fairchild, M. Tone, and H. Waldmann Expression of Murine IL-12 Is Regulated by Translational Control of the p35 Subunit J. Immunol., April 1, 1999; 162(7): 4069 - 4078. [Abstract] [Full Text] [PDF] P. Isler, B. G. de Rochemonteix, F. Songeon, N. Boehringer, and L. P. Nicod Interleukin-12 Production by Human Alveolar Macrophages Is Controlled by the Autocrine Production of Interleukin-10 Am. J. Respir. Cell Mol. Biol., February 1, 1999; 20(2): 270 - 278. [Abstract] [Full Text] J. Hodge-Dufour, M. W. Marino, M. R. Horton, A. Jungbluth, M. D. Burdick, R. M. Strieter, P. W. Noble, C. A. Hunter, and E. Pure Inhibition of interferon gamma  induced interleukin 12 production: A potential mechanism for the anti-inflammatory activities of tumor necrosis factor PNAS, November 10, 1998; 95(23): 13806 - 13811. [Abstract] [Full Text] [PDF] S. Haraguchi, N. K. Day, R. P. Nelson Jr., P. Emmanuel, J. E. Duplantier, C. S. Christodoulou, and R. A. Good Interleukin 12 deficiency associated with recurrent infections PNAS, October 27, 1998; 95(22): 13125 - 13129. [Abstract] [Full Text] [PDF] K. Collison, S. Saleh, R. Parhar, B. Meyer, A. Kwaasi, K. Al-Hussein, S. Al-Sedairy, and F. Al-Mohanna Evidence for IL-12-Activated Ca2+ and Tyrosine Signaling Pathways in Human Neutrophils J. Immunol., October 1, 1998; 161(7): 3737 - 3745. [Abstract] [Full Text] [PDF] J. Wang, G. Roderiquez, T. Oravecz, and M. A. Norcross Cytokine Regulation of Human Immunodeficiency Virus Type 1 Entry and Replication in Human Monocytes/Macrophages through Modulation of CCR5 Expression J. Virol., September 1, 1998; 72(9): 7642 - 7647. [Abstract] [Full Text] [PDF] P. Hermann, M. Rubio, T. Nakajima, G. Delespesse, and M. Sarfati IFN-{alpha} Priming of Human Monocytes Differentially Regulates Gram-Positive and Gram-Negative Bacteria-Induced IL-10 Release and Selectively Enhances IL-12p70, CD80, and MHC Class I Expression J. Immunol., August 15, 1998; 161(4): 2011 - 2018. [Abstract] [Full Text] [PDF] V. A. Katz, O. U. Thulke, and U. Conrath A Benzothiadiazole Primes Parsley Cells for Augmented Elicitation of Defense Responses Plant Physiology, August 1, 1998; 117(4): 1333 - 1339. [Abstract] [Full Text] M. P. Hayes, F. J. Murphy, and P. R. Burd Interferon-gamma -Dependent Inducible Expression of the Human Interleukin-12 p35 Gene in Monocytes Initiates From a TATA-Containing Promoter Distinct From the CpG-Rich Promoter Active in Epstein-Barr Virus-Transformed Lymphoblastoid Cells Blood, June 15, 1998; 91(12): 4645 - 4651. [Abstract] [Full Text] [PDF] B. D. Freimark, H. P. Blezinger, V. J. Florack, J. L. Nordstrom, S. D. Long, D. S. Deshpande, S. Nochumson, and K. L. Petrak Cationic Lipids Enhance Cytokine and Cell Influx Levels in the Lung Following Administration of Plasmid: Cationic Lipid Complexes J. Immunol., May 1, 1998; 160(9): 4580 - 4586. [Abstract] [Full Text] [PDF] P. Zhou and R. A. Seder CD40 Ligand Is Not Essential for Induction of Type 1 Cytokine Responses or Protective Immunity after Primary or Secondary Infection With Histoplasma capsulatum J. Exp. Med., April 20, 1998; 187(8): 1315 - 1324. [Abstract] [Full Text] [PDF] J. F. McDyer, T. J. Goletz, E. Thomas, C. H. June, and R. A. Seder CD40 Ligand/CD40 Stimulation Regulates the Production of IFN-{gamma} from Human Peripheral Blood Mononuclear Cells in an IL-12- and/or CD28-Dependent Manner J. Immunol., February 15, 1998; 160(4): 1701 - 1707. [Abstract] [Full Text] [PDF] H. L. Dickensheets, S. L. Freeman, M. F. Smith Jr, and R. P. Donnelly Interleukin-10 Upregulates Tumor Necrosis Factor Receptor Type-II (p75) Gene Expression in Endotoxin-Stimulated Human Monocytes Blood, November 15, 1997; 90(10): 4162 - 4171. [Abstract] [Full Text] [PDF] C. M.U. Hilkens, P. Kalinski, M. de Boer, and M. L. Kapsenberg Human Dendritic Cells Require Exogenous Interleukin-12-Inducing Factors to Direct the Development of Naive T-Helper Cells Toward the Th1 Phenotype Blood, September 1, 1997; 90(5): 1920 - 1926. [Abstract] [Full Text] [PDF] F. S. Sutterwala, G. J. Noel, R. Clynes, and D. M. Mosser Selective Suppression of Interleukin-12 Induction after Macrophage Receptor Ligation J. Exp. Med., June 2, 1997; 185(11): 1977 - 1985. [Abstract] [Full Text] [PDF] W. Ertel, M. Keel, R. Neidhardt, U. Steckholzer, J.-P. Kremer, U. Ungethuem, and O. Trentz Inhibition of the Defense System Stimulating Interleukin-12 Interferon-gamma Pathway During Critical Illness Blood, March 1, 1997; 89(5): 1612 - 1620. [Abstract] [Full Text] [PDF] F. Re and J. L. Strominger Toll-like Receptor 2 (TLR2) and TLR4 Differentially Activate Human Dendritic Cells J. Biol. Chem., September 28, 2001; 276(40): 37692 - 37699. [Abstract] [Full Text] [PDF]

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