|
|
 Previous Article | Table of Contents | Next Article 
Human immunodeficiency virus-type 1 replication can be increased in
peripheral blood of seropositive patients after influenza vaccination
WA O'Brien, K Grovit-Ferbas, A Namazi, S Ovcak-Derzic, HJ Wang, J Park, C Yeramian, SH Mao and JA Zack
Veterans Affairs Medical Center, Department of Medicine, West Los Angeles,
CA, USA.
Despite considerable evidence that cell activation enhances human
immunodeficiency virus-type 1 (HIV-1) replication in vitro, there is very
little data on the role of immune activation on in vivo HIV-1 replication.
In this study, we examined the effect of influenza vaccination on HIV-1
replication in the peripheral blood of 20 study subjects, and in 14 control
subjects who did not receive influenza vaccination. Blood was obtained from
each subject on three occasions during the month before vaccination and
again on three occasions during the following month. Over the study period,
there was little change in levels of proviral DNA in peripheral blood
mononuclear cells (PBMCs). However, peak PBMC viral RNA levels after
influenza vaccination were significantly increased over the mean of
prevaccination values. This change was not observed to the same extent in
unvaccinated controls. Therefore, this is the first report showing that
HIV-1 replication can increase in temporal association with influenza
vaccination. Our results suggest that continued immunologic (antigenic)
stimulation may result in increased virus load in vivo. To address the
appropriateness of influenza vaccination in HIV-infected patients, expanded
studies will be required to examine specific and generalized immune
responses to vaccination, and differences in patient response based on
disease stage.
Volume 86,
Issue 3,
pp. 1082-1089,
08/01/1995
Copyright © 1995 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
P. Durando, D. Fenoglio, A. Boschini, F. Ansaldi, G. Icardi, L. Sticchi, A. Renzoni, P. Fabbri, A. Ferrera, A. Parodi, et al.
Safety and Immunogenicity of Two Influenza Virus Subunit Vaccines, with or without MF59 Adjuvant, Administered to Human Immunodeficiency Virus Type 1-Seropositive and -Seronegative Adults
Clin. Vaccine Immunol.,
February 1, 2008;
15(2):
253 - 259.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Committee on Infectious Diseases
Recommendations for Influenza Immunization of Children
Pediatrics,
May 1, 2004;
113(5):
1441 - 1447.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. B. Rennels, H. C. Meissner, and Committee on Infectious Diseases
Technical Report: Reduction of the Influenza Burden in Children
Pediatrics,
December 1, 2002;
110(6):
e80 - e80.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Committee on Infectious Diseases
Reduction of the Influenza Burden in Children
Pediatrics,
December 1, 2002;
110(6):
1246 - 1252.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Richardson, S. Broche, S. Baud, T. Leste-Lasserre, F. Femenia, D. Levy, A. Moraillon, G. Pancino, and P. Sonigo
Lymphoid activation: a confounding factor in AIDS vaccine development?
J. Gen. Virol.,
October 1, 2002;
83(10):
2515 - 2521.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Fontana, R. Schut, and H. Rabb
Can choice of dialyser membrane have a beneficial effect on HIV load in the HIV-infected dialysis patient?
Nephrol. Dial. Transplant.,
March 1, 2002;
17(3):
529 - 530.
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Levine
Evaluation and Management of HIV-Infected Women
Ann Intern Med,
February 5, 2002;
136(3):
228 - 242.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. D. Lawn, S. T. Butera, and T. M. Folks
Contribution of Immune Activation to the Pathogenesis and Transmission of Human Immunodeficiency Virus Type 1 Infection
Clin. Microbiol. Rev.,
October 1, 2001;
14(4):
753 - 777.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Clerici, S. Declich, and G. Rizzardini
African Enigma: Key Player in Human Immunodeficiency Virus Pathogenesis in Developing Countries?
Clin. Vaccine Immunol.,
September 1, 2001;
8(5):
864 - 866.
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. V. Havlir, R. Bassett, D. Levitan, P. Gilbert, P. Tebas, A. C. Collier, M. S. Hirsch, C. Ignacio, J. Condra, H. F. Gunthard, et al.
Prevalence and Predictive Value of Intermittent Viremia With Combination HIV Therapy
JAMA,
July 11, 2001;
286(2):
171 - 179.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. W. Chen, Y. Shen, D. Zhou, M. Simon, Z. Kou, D. Lee-Parritz, L. Shen, P. Sehgal, and N. L. Letvin
In Vivo T-Lymphocyte Activation and Transient Reduction of Viral Replication in Macaques Infected with Simian Immunodeficiency Virus
J. Virol.,
May 15, 2001;
75(10):
4713 - 4720.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
D. Scales, H. Ni, F. Shaheen, J. Capodici, G. Cannon, and D. Weissman
Nonproliferating Bystander CD4+ T Cells Lacking Activation Markers Support HIV Replication During Immune Activation
J. Immunol.,
May 15, 2001;
166(10):
6437 - 6443.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Lin and K. L. Nichol
Excess Mortality Due to Pneumonia or Influenza During Influenza Seasons Among Persons With Acquired Immunodeficiency Syndrome
Arch Intern Med,
February 12, 2001;
161(3):
441 - 446.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Kilby, P. A. Goepfert, A. P. Miller, J. W. Gnann Jr., M. Sillers, M. S. Saag, and R. P. Bucy
Recurrence of the Acute HIV Syndrome after Interruption of Antiretroviral Therapy in a Patient with Chronic HIV Infection: A Case Report
Ann Intern Med,
September 19, 2000;
133(6):
435 - 438.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. J. Wiegers, I. E. M. Stec, W. E. F. Klinkert, and J. M. H. M. Reul
Glucocorticoids Regulate TCR-Induced Elevation of CD4: Functional Implications
J. Immunol.,
June 15, 2000;
164(12):
6213 - 6220.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. A. Pinto, V. Blazevic, B. K. Patterson, C. Mac Trubey, M. J. Dolan, and G. M. Shearer
Inhibition of Human Immunodeficiency Virus Type 1 Replication prior to Reverse Transcription by Influenza Virus Stimulation
J. Virol.,
May 15, 2000;
74(10):
4505 - 4511.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
N. M. Ferguson, F. deWolf, A. C. Ghani, C. Fraser, C. A. Donnelly, P. Reiss, J. M. A. Lange, S. A. Danner, G. P. Garnett, J. Goudsmit, et al.
Antigen-driven CD4+ T cell and HIV-1 dynamics: Residual viral replication under highly active antiretroviral therapy
PNAS,
December 21, 1999;
96(26):
15167 - 15172.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Severson and S. K. Tyring
Relation Between Herpes Simplex Viruses and Human Immunodeficiency Virus Infections
Arch Dermatol,
November 1, 1999;
135(11):
1393 - 1397.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A. Tasker, J. J. Treanor, W. B. Paxton, and M. R. Wallace
Efficacy of Influenza Vaccination in HIV-Infected Persons: A Randomized, Double-Blind, Placebo-Controlled Trial
Ann Intern Med,
September 21, 1999;
131(6):
430 - 433.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Moriuchi, M. Moriuchi, and A. S. Fauci
Induction of HIV-1 Replication by Allogeneic Stimulation
J. Immunol.,
June 15, 1999;
162(12):
7543 - 7548.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Zhou, Y. Shen, L. Chalifoux, D. Lee-Parritz, M. Simon, P. K. Sehgal, L. Zheng, M. Halloran, and Z. W. Chen
Mycobacterium bovis Bacille Calmette-Guerin Enhances Pathogenicity of Simian Immunodeficiency Virus Infection and Accelerates Progression to AIDS in Macaques: A Role of Persistent T cell Activation in AIDS Pathogenesis
J. Immunol.,
February 15, 1999;
162(4):
2204 - 2216.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Wahl, T. Greenwell-Wild, G. Peng, H. Hale-Donze, T. M. Doherty, D. Mizel, and J. M. Orenstein
Mycobacterium avium complex augments macrophage HIV-1 production and increases CCR5 expression
PNAS,
October 13, 1998;
95(21):
12574 - 12579.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Ostrowski, D. C. Krakauer, Y. Li, S. J. Justement, G. Learn, L. A. Ehler, S. K. Stanley, M. Nowak, and A. S. Fauci
Effect of Immune Activation on the Dynamics of Human Immunodeficiency Virus Replication and on the Distribution of Viral Quasispecies
J. Virol.,
October 1, 1998;
72(10):
7772 - 7784.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Gelfand, D. Rudikoff, M. Lebwohl, and M. E. Klotman
Effect of UV-B Phototherapy on Plasma HIV Type 1 RNA Viral Level: A Self-controlled Prospective Study
Arch Dermatol,
August 1, 1998;
134(8):
940 - 945.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T.-W. Chun, D. Engel, S. B. Mizell, L. A. Ehler, and A. S. Fauci
Induction of HIV-1 Replication in Latently Infected CD4+ T Cells Using a Combination of Cytokines
J. Exp. Med.,
July 1, 1998;
188(1):
83 - 91.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Schacker, A. J. Ryncarz, J. Goddard, K. Diem, M. Shaughnessy, and L. Corey
Frequent Recovery of HIV-1 From Genital Herpes Simplex Virus Lesions in HIV-1-Infected Men
JAMA,
July 1, 1998;
280(1):
61 - 66.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Bartlett
Strategies of Antiretroviral Therapy in Adults
Oncologist,
April 1, 1998;
3(2):
111 - 118.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. I. Connor, B. T. M. Korber, B. S. Graham, B. H. Hahn, D. D. Ho, B. D. Walker, A. U. Neumann, S. H. Vermund, J. Mestecky, S. Jackson, et al.
Immunological and Virological Analyses of Persons Infected by Human Immunodeficiency Virus Type 1 while Participating in Trials of Recombinant gp120 Subunit Vaccines
J. Virol.,
February 1, 1998;
72(2):
1552 - 1576.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L.-a. Pirofski and A. Casadevall
Use of Licensed Vaccines for Active Immunization of the Immunocompromised Host
Clin. Microbiol. Rev.,
January 1, 1998;
11(1):
1 - 26.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. A. Benne, F. P. Kroon, M. Harmsen, L. Tavares, C. A. Kraaijeveld, and J. C. De Jong
Comparison of Neutralizing and Hemagglutination-Inhibiting Antibody Responses to Influenza A Virus Vaccination of Human Immunodeficiency Virus-Infected Individuals
Clin. Vaccine Immunol.,
January 1, 1998;
5(1):
114 - 117.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
E G H Lyall, A Charlett, P Watkins, and M Zambon
Response to influenza virus vaccination in vertical HIV infection
Arch. Dis. Child.,
March 1, 1997;
76(3):
215 - 218.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
C.-M. Farber, A. A. Barath, T. Dieye, F. P. Kroon, R. van Furth, S. M. Bruisten, S. K. Stanley, M. A. Ostrowski, and A. S. Fauci
The Effects of Immunization in Human Immunodeficiency Virus Type 1 Infection
N. Engl. J. Med.,
September 12, 1996;
335(11):
817 - 819.
[Full Text]
|
|
|
|
|
|
|
S. K. Stanley, M. A. Ostrowski, J. S. Justement, K. Gantt, S. Hedayati, M. Mannix, K. Roche, D. J. Schwartzentruber, C. H. Fox, and A. S. Fauci
Effect of Immunization with a Common Recall Antigen on Viral Expression in Patients Infected with Human Immunodeficiency Virus Type 1
N. Engl. J. Med.,
May 9, 1996;
334(19):
1222 - 1229.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. H. Cheeseman, R. E. Davaro, and R. T. Ellison
Hepatitis B Vaccination and Plasma HIV-1 RNA
N. Engl. J. Med.,
May 9, 1996;
334(19):
1272 - 1272.
[Full Text]
|
|
|
|
|
|
|
W. A. O'Brien, P. M. Hartigan, D. Martin, J. Esinhart, A. Hill, S. Benoit, M. Rubin, M. S. Simberkoff, and J. D. Hamilton
Changes in Plasma HIV-1 RNA and CD4+ Lymphocyte Counts and the Risk of Progression to AIDS
N. Engl. J. Med.,
February 15, 1996;
334(7):
426 - 431.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Routine Immunization in HIV: Helpful or Harmful?
AIDS Clinical Care,
February 1, 1996;
1996(201):
1 - 1.
[Full Text]
|
|
|
|
|
