|
|
 Previous Article | Table of Contents | Next Article 
Human mononuclear phagocyte inducible nitric oxide synthase (iNOS):
analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production
by blood monocytes and peritoneal macrophages
JB Weinberg, MA Misukonis, PJ Shami, SN Mason, DL Sauls, WA Dittman, ER Wood, GK Smith, B McDonald and KE Bachus
Department of Medicine, Veterans Affairs, Medical Center, Durham, NC.
Nitric oxide (NO) is produced by numerous different cell types, and it is
an important regulator and mediator of many processes including smooth
muscle relaxation, neurotransmission, and murine macrophage- mediated
cytotoxicity for microbes and tumor cells. Although murine macrophages
produce NO readily after activation, human monocytes and tissue macrophages
have been reported to produce only low levels of NO in vitro. The purpose
of this study was to determine if stimulated human mononuclear phagocytes
produce inducible nitric oxide synthase (iNOS) mRNA, protein, and enzymatic
activity. By reverse transcriptase- polymerase chain reaction (RT-PCR)
analysis, we show that human monocytes can be induced to express iNOS mRNA
after treatment with lipopolysaccharide (LPS) and/or interferon-gamma
(IFN-gamma). By immunofluorescence and immunoblot analyses, we show
monocytes and peritoneal macrophages contain detectable levels of iNOS
antigen after stimulations with cytokines in vitro. Control monocytes or
those cultured with LPS and/or various cytokines have low levels of NOS
functional activity as measured by the ability of cell extracts to convert
L-arginine to L-citrulline, and they produce low levels of the NO
catabolites nitrite and nitrate. Peritoneal macrophages have significantly
enhanced nitrite/nitrate production and NOS activity after treatment with
LPS and/or IFN-gamma, whereas monocyte nitrite/nitrate production and NOS
activity are not altered by the treatments. Monocytes cultured with various
live or heat-killed bacteria, fungi, or human immunodeficiency virus
(HIV)-1 do not produce high levels of nitrite/nitrate. Antibodies against
transforming growth factor-beta (TGF-beta), a factor known to inhibit iNOS
expression and NO production in mouse macrophages, do not enhance NO
production in human monocytes or macrophages. Biopterin, an obligate
cofactor of iNOS enzymatic activity, is undetectable in freshly isolated or
cultured human monocytes and peritoneal macrophages. However, replenishment
of intracellular levels of tetrahydrobiopterin by culture with the cell-
permeable, nontoxic precursor sepiapterin does not enhance the abilities of
the human mononuclear phagocytes to produce NO in vitro. Mixing experiments
show no evidence of a functional NOS inhibitor in human mononuclear
phagocytes. Thus, we demonstrate that human mononuclear phagocytes can
produce iNOS mRNA and protein, and (despite this) their abilities to
generate NO are very low.
Volume 86,
Issue 3,
pp. 1184-1195,
08/01/1995
Copyright © 1995 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
D. M. Wilcock, N. Gharkholonarehe, W. E. Van Nostrand, J. Davis, M. P. Vitek, and C. A. Colton
Amyloid Reduction by Amyloid-{beta} Vaccination Also Reduces Mouse Tau Pathology and Protects from Neuron Loss in Two Mouse Models of Alzheimer's Disease
J. Neurosci.,
June 24, 2009;
29(25):
7957 - 7965.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M. Otto, K. Markstaller, O. Kajikawa, J. Karmrodt, R. S. Syring, B. Pfeiffer, V. P. Good, C. W. Frevert, and J. E. Baumgardner
Spatial and temporal heterogeneity of ventilator-associated lung injury after surfactant depletion
J Appl Physiol,
May 1, 2008;
104(5):
1485 - 1494.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Wilcock, M. R. Lewis, W. E. Van Nostrand, J. Davis, M. L. Previti, N. Gharkholonarehe, M. P. Vitek, and C. A. Colton
Progression of Amyloid Pathology to Alzheimer's Disease Pathology in an Amyloid Precursor Protein Transgenic Mouse Model by Removal of Nitric Oxide Synthase 2
J. Neurosci.,
February 13, 2008;
28(7):
1537 - 1545.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Cuzzocrea, S. Bruscoli, E. Mazzon, C. Crisafulli, V. Donato, R. Di Paola, E. Velardi, E. Esposito, G. Nocentini, and C. Riccardi
Peroxisome Proliferator-Activated Receptor-{alpha} Contributes to the Anti-Inflammatory Activity of Glucocorticoids
Mol. Pharmacol.,
February 1, 2008;
73(2):
323 - 337.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. T. Liu, S. Stenger, D. H. Tang, and R. L. Modlin
Cutting Edge: Vitamin D-Mediated Human Antimicrobial Activity against Mycobacterium tuberculosis Is Dependent on the Induction of Cathelicidin
J. Immunol.,
August 15, 2007;
179(4):
2060 - 2063.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. T. Lee, J. H. Hong, C. Kwak, J. Woo, V. Liu, C. Lee, and I. Y. Kim
Effect of Dominant Negative Transforming Growth Factor-{beta} Receptor Type II on Cytotoxic Activity of RAW 264.7, a Murine Macrophage Cell Line
Cancer Res.,
July 15, 2007;
67(14):
6717 - 6724.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Nicolas, D. Cathelin, N. Larmonier, J. Fraszczak, P.-E. Puig, A. Bouchot, A. Bateman, E. Solary, and B. Bonnotte
Dendritic Cells Trigger Tumor Cell Death by a Nitric Oxide-Dependent Mechanism
J. Immunol.,
July 15, 2007;
179(2):
812 - 818.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Ziesche, M. Bachmann, H. Kleinert, J. Pfeilschifter, and H. Muhl
The Interleukin-22/STAT3 Pathway Potentiates Expression of Inducible Nitric-oxide Synthase in Human Colon Carcinoma Cells
J. Biol. Chem.,
June 1, 2007;
282(22):
16006 - 16015.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Lombardo, A. Alvarez-Barrientos, B. Maroto, L. Bosca, and U. G. Knaus
TLR4-Mediated Survival of Macrophages Is MyD88 Dependent and Requires TNF-{alpha} Autocrine Signalling
J. Immunol.,
March 15, 2007;
178(6):
3731 - 3739.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. B. Sable, D. Goyal, I. Verma, D. Behera, and G. K. Khuller
Lung and blood mononuclear cell responses of tuberculosis patients to mycobacterial proteins
Eur. Respir. J.,
February 1, 2007;
29(2):
337 - 346.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Bultinck, P. Sips, L. Vakaet, P. Brouckaert, and A. Cauwels
Systemic NO production during (septic) shock depends on parenchymal and not on hematopoietic cells: in vivo iNOS expression pattern in (septic) shock
FASEB J,
November 1, 2006;
20(13):
2363 - 2365.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. A. Colton, M. P. Vitek, D. A. Wink, Q. Xu, V. Cantillana, M. L. Previti, W. E. Van Nostrand, J. B. Weinberg, and H. Dawson
NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease
PNAS,
August 22, 2006;
103(34):
12867 - 12872.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Knaapen, N. Gungor, R. P. F. Schins, P. J. A. Borm, and F. J. Van Schooten
Neutrophils and respiratory tract DNA damage and mutagenesis: a review
Mutagenesis,
July 1, 2006;
21(4):
225 - 236.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. E. Perez, B. Chandrasekar, O. A. Saldarriaga, W. Zhao, L. T. Arteaga, B. L. Travi, and P. C. Melby
Reduced Nitric Oxide Synthase 2 (NOS2) Promoter Activity in the Syrian Hamster Renders the Animal Functionally Deficient in NOS2 Activity and Unable to Control an Intracellular Pathogen
J. Immunol.,
May 1, 2006;
176(9):
5519 - 5528.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. A. Butcher, R. I. Greene, S. C. Henry, K. L. Annecharico, J. B. Weinberg, E. Y. Denkers, A. Sher, and G. A. Taylor
p47 GTPases Regulate Toxoplasma gondii Survival in Activated Macrophages
Infect. Immun.,
June 1, 2005;
73(6):
3278 - 3286.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. M. Stevanin, J. W. B. Moir, and R. C. Read
Nitric Oxide Detoxification Systems Enhance Survival of Neisseria meningitidis in Human Macrophages and in Nasopharyngeal Mucosa
Infect. Immun.,
June 1, 2005;
73(6):
3322 - 3329.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Mollace, C. Muscoli, E. Masini, S. Cuzzocrea, and D. Salvemini
Modulation of Prostaglandin Biosynthesis by Nitric Oxide and Nitric Oxide Donors
Pharmacol. Rev.,
June 1, 2005;
57(2):
217 - 252.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Reade, J. L. Millo, J. D. Young, and C. A. R. Boyd
Nitric oxide synthase is downregulated, while haem oxygenase is increased, in patients with septic shock
Br. J. Anaesth.,
April 1, 2005;
94(4):
468 - 473.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. S. Boutlis, J. B. Weinberg, J. Baker, M. J. Bockarie, C. S. Mgone, Q. Cheng, and N. M. Anstey
Nitric Oxide Production and Nitric Oxide Synthase Activity in Malaria-Exposed Papua New Guinean Children and Adults Show Longitudinal Stability and No Association with Parasitemia
Infect. Immun.,
December 1, 2004;
72(12):
6932 - 6938.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Gilchrist, S. D. McCauley, and A. D. Befus
Expression, localization, and regulation of NOS in human mast cell lines: effects on leukotriene production
Blood,
July 15, 2004;
104(2):
462 - 469.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Raju, Y. Hoshino, K. Kuwabara, I. Belitskaya, S. Prabhakar, A. Canova, J. A. Gold, R. Condos, R. I. Pine, S. Brown, et al.
Aerosolized Gamma Interferon (IFN-{gamma}) Induces Expression of the Genes Encoding the IFN-{gamma}-Inducible 10-Kilodalton Protein but Not Inducible Nitric Oxide Synthase in the Lung during Tuberculosis
Infect. Immun.,
March 1, 2004;
72(3):
1275 - 1283.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. S. BOUTLIS, M. R. HOBBS, R. L. MARSH, M. A. MISUKONIS, A. N. TKACHUK, M. LAGOG, J. BOOTH, D. L. GRANGER, M. J. BOCKARIE, C. S. MGONE, et al.
INDUCIBLE NITRIC OXIDE SYNTHASE (NOS2) PROMOTER CCTTT REPEAT POLYMORPHISM: RELATIONSHIP TO IN VIVO NITRIC OXIDE PRODUCTION/NOS ACTIVITY IN AN ASYMPTOMATIC MALARIA-ENDEMIC POPULATION
Am J Trop Med Hyg,
December 1, 2003;
69(6):
569 - 573.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. S. Boutlis, M. Lagog, S. Chaisavaneeyakorn, M. A. Misukonis, M. J. Bockarie, C. S. Mgone, Z. Wang, G. Morahan, J. B. Weinberg, V. Udhayakumar, et al.
Plasma Interleukin-12 in Malaria-Tolerant Papua New Guineans: Inverse Correlation with Plasmodium falciparum Parasitemia and Peripheral Blood Mononuclear Cell Nitric Oxide Synthase Activity
Infect. Immun.,
November 1, 2003;
71(11):
6354 - 6357.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Y. Poon, E. Raharjo, K. D. Patel, S. Tavener, and P. Kubes
Complexity of Inducible Nitric Oxide Synthase: Cellular Source Determines Benefit Versus Toxicity
Circulation,
September 2, 2003;
108(9):
1107 - 1112.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. S. Boutlis, E. Tjitra, H. Maniboey, M. A. Misukonis, J. R. Saunders, S. Suprianto, J. B. Weinberg, and N. M. Anstey
Nitric Oxide Production and Mononuclear Cell Nitric Oxide Synthase Activity in Malaria-Tolerant Papuan Adults
Infect. Immun.,
July 1, 2003;
71(7):
3682 - 3689.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-j. Shin, B. Fermor, J. B. Weinberg, D. S. Pisetsky, and F. Guilak
Regulation of matrix turnover in meniscal explants: role of mechanical stress, interleukin-1, and nitric oxide
J Appl Physiol,
July 1, 2003;
95(1):
308 - 313.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T.-A. Kim, H. K. Avraham, Y.-H. Koh, S. Jiang, I.-W. Park, and S. Avraham
HIV-1 Tat-Mediated Apoptosis in Human Brain Microvascular Endothelial Cells
J. Immunol.,
March 1, 2003;
170(5):
2629 - 2637.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Reade and J. D. Young
Editorial I: Of mice and men (and rats): implications of species and stimulus differences for the interpretation of studies of nitric oxide in sepsis
Br. J. Anaesth.,
February 1, 2003;
90(2):
115 - 121.
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Tuckova, J. Novotna, P. Novak, Z. Flegelova, T. Kveton, L. Jelinkova, Z. Zidek, P. Man, and H. Tlaskalova-Hogenova
Activation of macrophages by gliadin fragments: isolation and characterization of active peptide
J. Leukoc. Biol.,
April 1, 2002;
71(4):
625 - 631.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Pfister, K. A. Remer, M. Brcic, R. Fatzer, S. Christen, S. Leib, and T. W. Jungi
Inducible Nitric Oxide Synthase and Nitrotyrosine in Listeric Encephalitis: A Cross-species Study in Ruminants
Vet. Pathol.,
March 1, 2002;
39(2):
190 - 199.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. K. Ghosh, M. A. Misukonis, C. Reich, D. S. Pisetsky, and J. B. Weinberg
Host Response to Infection: the Role of CpG DNA in Induction of Cyclooxygenase 2 and Nitric Oxide Synthase 2 in Murine Macrophages
Infect. Immun.,
December 1, 2001;
69(12):
7703 - 7710.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. D. Chan, J. Chan, and N. W. Schluger
What is the Role of Nitric Oxide in Murine and Human Host Defense against Tuberculosis? . Current Knowledge
Am. J. Respir. Cell Mol. Biol.,
November 1, 2001;
25(5):
606 - 612.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R.B.R. Muijsers, N.H.T. ten Hacken, I. Van Ark, G. Folkerts, F.P. Nijkamp, and D.S. Postma
L-Arginine is not the limiting factor for nitric oxide synthesis by human alveolar macrophages in vitro
Eur. Respir. J.,
October 1, 2001;
18(4):
667 - 671.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Allanore, D. Borderie, P. Hilliquin, A. Hernvann, M. Levacher, H. Lemarechal, O. G. Ekindjian, and A. Kahan
Low levels of nitric oxide (NO) in systemic sclerosis: inducible NO synthase production is decreased in cultured peripheral blood monocyte/macrophage cells
Rheumatology,
October 1, 2001;
40(10):
1089 - 1096.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Lehner, T. Felzmann, K. Clodi, and W. Holter
Type I interferons in combination with bacterial stimuli induce apoptosis of monocyte-derived dendritic cells
Blood,
August 1, 2001;
98(3):
736 - 742.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. A. Remer, T. W. Jungi, R. Fatzer, M. G. Tauber, and S. L. Leib
Nitric Oxide Is Protective in Listeric Meningoencephalitis of Rats
Infect. Immun.,
June 1, 2001;
69(6):
4086 - 4093.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Hori, M. Kita, S. Torihashi, S. Miyamoto, K.-J. Won, K. Sato, H. Ozaki, and H. Karaki
Upregulation of iNOS by COX-2 in muscularis resident macrophage of rat intestine stimulated with LPS
Am J Physiol Gastrointest Liver Physiol,
May 1, 2001;
280(5):
G930 - G938.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M. Otto and J. E. Baumgardner
Effect of culture PO2 on macrophage (RAW 264.7) nitric oxide production
Am J Physiol Cell Physiol,
February 1, 2001;
280(2):
C280 - C287.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. LANONE, A. MEBAZAA, C. HEYMES, D. HENIN, J. J. PODEROSO, Y. PANIS, C. ZEDDA, T. BILLIAR, D. PAYEN, M. AUBIER, et al.
Muscular Contractile Failure in Septic Patients . Role of the Inducible Nitric Oxide Synthase Pathway
Am. J. Respir. Crit. Care Med.,
December 1, 2000;
162(6):
2308 - 2315.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. Nakayama, N. Kayagaki, N. Yamaguchi, K. Okumura, and H. Yagita
Involvement of Tweak in Interferon {gamma}-Stimulated Monocyte Cytotoxicity
J. Exp. Med.,
November 6, 2000;
192(9):
1373 - 1380.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Lopez-Urrutia, A. Alonso, M. L. Nieto, Y. Bayon, A. Orduna, and M. Sanchez Crespo
Lipopolysaccharides of Brucella abortus and Brucella melitensis Induce Nitric Oxide Synthesis in Rat Peritoneal Macrophages
Infect. Immun.,
March 1, 2000;
68(3):
1740 - 1745.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. S. Duffield, L.-P. Erwig, X.-q. Wei, F. Y. Liew, A. J. Rees, and J. S. Savill
Activated Macrophages Direct Apoptosis and Suppress Mitosis of Mesangial Cells
J. Immunol.,
February 15, 2000;
164(4):
2110 - 2119.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Comini, T. Bachetti, L. Agnoletti, G. Gaia, S. Curello, B. Milanesi, M. Volterrani, G. Parrinello, C. Ceconi, A. Giordano, et al.
Induction of functional inducible nitric oxide synthase in monocytes of patients with congestive heart failure. Link with tumour necrosis factor-{alpha}
Eur. Heart J.,
October 2, 1999;
20(20):
1503 - 1513.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. Guillemard, B. Varano, F. Belardelli, A. M. Quero, and S. Gessani
Inhibitory Activity of Constitutive Nitric Oxide on the Expression of Alpha/Beta Interferon Genes in Murine Peritoneal Macrophages
J. Virol.,
September 1, 1999;
73(9):
7328 - 7333.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
K. Furuke, P. R. Burd, J. A. Horvath-Arcidiacono, K. Hori, H. Mostowski, and E. T. Bloom
Human NK Cells Express Endothelial Nitric Oxide Synthase, and Nitric Oxide Protects Them from Activation-Induced Cell Death by Regulating Expression of TNF-{alpha}
J. Immunol.,
August 1, 1999;
163(3):
1473 - 1480.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Ekman, M. Saarinen, Q. He, M. Virtala, M. Salmi, and K. Granfors
Human Monocytic U937 Cells Kill Salmonella In Vitro by NO-Independent Mechanisms
Infect. Immun.,
July 1, 1999;
67(7):
3670 - 3673.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. W. Mullins, C. J. Burger, and K. D. Elgert
Paclitaxel Enhances Macrophage IL-12 Production in Tumor-Bearing Hosts Through Nitric Oxide
J. Immunol.,
June 1, 1999;
162(11):
6811 - 6818.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. S. Griffith, S. R. Wiley, M. Z. Kubin, L. M. Sedger, C. R. Maliszewski, and N. A. Fanger
Monocyte-mediated Tumoricidal Activity via the Tumor Necrosis Factor-related Cytokine, TRAIL
J. Exp. Med.,
April 19, 1999;
189(8):
1343 - 1354.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. A. Boven, L. Gomes, C. Hery, F. Gray, J. Verhoef, P. Portegies, M. Tardieu, and H. S. L. M. Nottet
Increased Peroxynitrite Activity in AIDS Dementia Complex: Implications for the Neuropathogenesis of HIV-1 Infection
J. Immunol.,
April 1, 1999;
162(7):
4319 - 4327.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Brito, M. Naviliat, A. C. Tiscornia, F. Vuillier, G. Gualco, G. Dighiero, R. Radi, and A. M. Cayota
Peroxynitrite Inhibits T Lymphocyte Activation and Proliferation by Promoting Impairment of Tyrosine Phosphorylation and Peroxynitrite-Driven Apoptotic Death
J. Immunol.,
March 15, 1999;
162(6):
3356 - 3366.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Facchetti, W. Vermi, S. Fiorentini, M. Chilosi, A. Caruso, M. Duse, L. D. Notarangelo, and R. Badolato
Expression of Inducible Nitric Oxide Synthase in Human Granulomas and Histiocytic Reactions
Am. J. Pathol.,
January 1, 1999;
154(1):
145 - 152.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Zhao, N. Dugas, C. Mathiot, A. Delmer, B. Dugas, F. Sigaux, and J.-P. Kolb
B-Cell Chronic Lymphocytic Leukemia Cells Express a Functional Inducible Nitric Oxide Synthase Displaying Anti-Apoptotic Activity
Blood,
August 1, 1998;
92(3):
1031 - 1043.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. L. Oleszak, E. Zaczynska, M. Bhattacharjee, C. Butunoi, A. Legido, and C. D. Katsetos
Inducible Nitric Oxide Synthase and Nitrotyrosine Are Found in Monocytes/Macrophages and/or Astrocytes in Acute, but Not in Chronic, Multiple Sclerosis
Clin. Vaccine Immunol.,
July 1, 1998;
5(4):
438 - 445.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. J. LINNANE, V. M. KEATINGS, C. M. COSTELLO, J. B. MOYNIHAN, C. M. O'CONNOR, M. X. FITZGERALD, and P. MCLOUGHLIN
Total Sputum Nitrate plus Nitrite Is Raised during Acute Pulmonary Infection in Cystic Fibrosis
Am. J. Respir. Crit. Care Med.,
July 1, 1998;
158(1):
207 - 212.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Musso, L. Calosso, M. Zucca, M. Millesimo, M. Puliti, S. Bulfone-Paus, C. Merlino, D. Savoia, R. Cavallo, A. N. Ponzi, et al.
Interleukin-15 Activates Proinflammatory and Antimicrobial Functions in Polymorphonuclear Cells
Infect. Immun.,
June 1, 1998;
66(6):
2640 - 2647.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Shimizu, K.-i. Kinugawa, Y. Sugishita, K. Sugishita, K. Harada, H. Matsui, O. Kohmoto, T. Serizawa, and T. Takahashi
Molecular cloning and expression of inducible nitric oxide synthase in chick embryonic ventricular myocytes
Cardiovasc Res,
May 1, 1998;
38(2):
405 - 413.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Gross, S. Spiesser, A. Terraza, B. Rouot, E. Caron, and J. Dornand
Expression and Bactericidal Activity of Nitric Oxide Synthase in Brucella suis-Infected Murine Macrophages
Infect. Immun.,
April 1, 1998;
66(4):
1309 - 1316.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Turco, H. Liu, S. F. Gottlieb, and H. H. Winkler
Nitric Oxide-Mediated Inhibition of the Ability of Rickettsia prowazekii To Infect Mouse Fibroblasts and Mouse Macrophagelike Cells
Infect. Immun.,
February 1, 1998;
66(2):
558 - 566.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kim, O. Bang, Y. Lee, and S. Kang
Production of inducible nitric oxide is required for monocytic differentiation of U937 cells induced by vitamin E-succinate
J. Cell Sci.,
January 2, 1998;
111(4):
435 - 441.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. I. Sharara, D. J. Perkins, M. A. Misukonis, S. U. Chan, J. A. Dominitz, and J. B. Weinberg
Interferon (IFN)-{alpha} Activation of Human Blood Mononuclear Cells In Vitro and In Vivo for Nitric Oxide Synthase (NOS) Type 2 mRNA and Protein Expression: Possible Relationship of Induced NOS2 to the Anti-Hepatitis C Effects of IFN-{alpha} In Vivo
J. Exp. Med.,
November 3, 1997;
186(9):
1495 - 1502.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-W. Chow, A. Kapus, R. Romanek, and S. Grinstein
NO3--induced pH Changes in Mammalian Cells: Evidence for an NO3--H+ Cotransporter
J. Gen. Physiol.,
August 1, 1997;
110(2):
185 - 200.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Yan, S. Wang, S. P. Rafferty, R. A. Wesley, and R. L. Danner
Endogenously Produced Nitric Oxide Increases Tumor Necrosis Factor-alpha Production in Transfected Human U937 Cells
Blood,
August 1, 1997;
90(3):
1160 - 1167.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. FUJII, P. GOLDBERG, and S. N. A. HUSSAIN
Contribution of Macrophages to Pulmonary Nitric Oxide Production in Septic Shock
Am. J. Respir. Crit. Care Med.,
May 1, 1997;
157(5):
1645 - 1651.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. Ding, B. A.St. Pierre, J. F. Parkinson, P. Medberry, J. L. Wong, N. E. Rogers, L. J. Ignarro, and J. E. Merrill
Inducible Nitric-oxide Synthase and Nitric Oxide Production in Human Fetal Astrocytes and Microglia. A KINETIC ANALYSIS
J. Biol. Chem.,
April 25, 1997;
272(17):
11327 - 11335.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
