|
|
 Previous Article | Table of Contents | Next Article 
Peripheral T-cell lymphoma in lckpr-bcl-2 transgenic mice
GP Linette, JL Hess, CL Sentman and SJ Korsmeyer
Department of Medicine, Howard Hughes Medical Institute at Washington
University, St Louis, MO 63110, USA.
t(14;18) is the most common translocation in human lymphoid malignancy and
results in bcl-2 overexpression. Bcl-2 blocks apoptosis and constitutes the
initial member of a new category of oncogenes, ie, regulators of cell
death. Bcl-2-Ig transgenic mice develop follicular hyperplasia and progress
to malignant B-cell lymphoma. To assess the oncogenic potential of bcl-2 in
the T-cell lineage, a cohort of 68 lckpr-bcl-2 transgenic mice and 56
control littermates were monitored for signs of malignancy over a 24-month
period. Eighteen (26%) lckpr- bcl-2 mice developed diffuse, predominantly
large-cell lymphomas at a mean age of 18 months. In contrast, only one
nontransgenic control mouse developed lymphoma. CD3 surface expression and
clonal T-cell receptor beta rearrangements support the T-lineage
classification of these neoplasms. lckpr-bcl-2-enforced lymphomas are
predominantly CD4+CD8-, consistent with a mature peripheral T-cell
phenotype. These data provide support for the thesis that violation of
homeostasis through the repression of cell death can be a primary mechanism
of tumorigenesis in multiple lineages.
Volume 86,
Issue 4,
pp. 1255-1260,
08/15/1995
Copyright © 1995 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
Y. Janumyan, Q. Cui, L. Yan, C. G. Sansam, M. Valentin, and E. Yang
G0 Function of BCL2 and BCL-xL Requires BAX, BAK, and p27 Phosphorylation by Mirk, Revealing a Novel Role of BAX and BAK in Quiescence Regulation
J. Biol. Chem.,
December 5, 2008;
283(49):
34108 - 34120.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Zhao, F. Gao, Y. Zhang, K. Wei, Y. Liu, and X. Deng
Bcl2 Inhibits Abasic Site Repair by Down-regulating APE1 Endonuclease Activity
J. Biol. Chem.,
April 11, 2008;
283(15):
9925 - 9932.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Q. Ding, X. He, J.-M. Hsu, W. Xia, C.-T. Chen, L.-Y. Li, D.-F. Lee, J.-C. Liu, Q. Zhong, X. Wang, et al.
Degradation of Mcl-1 by {beta}-TrCP Mediates Glycogen Synthase Kinase 3-Induced Tumor Suppression and Chemosensitization
Mol. Cell. Biol.,
June 1, 2007;
27(11):
4006 - 4017.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Hou, F. Gao, Q. Wang, J. Zhao, T. Flagg, Y. Zhang, and X. Deng
Bcl2 Impedes DNA Mismatch Repair by Directly Regulating the hMSH2-hMSH6 Heterodimeric Complex
J. Biol. Chem.,
March 23, 2007;
282(12):
9279 - 9287.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Jin, W. S. May, F. Gao, T. Flagg, and X. Deng
Bcl2 Suppresses DNA Repair by Enhancing c-Myc Transcriptional Activity
J. Biol. Chem.,
May 19, 2006;
281(20):
14446 - 14456.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Bai, H.-M. Ni, X. Chen, D. DiFrancesca, and X.-M. Yin
Deletion of Bid Impedes Cell Proliferation and Hepatic Carcinogenesis
Am. J. Pathol.,
May 1, 2005;
166(5):
1523 - 1532.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Langenau, C. Jette, S. Berghmans, T. Palomero, J. P. Kanki, J. L. Kutok, and A. T. Look
Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish
Blood,
April 15, 2005;
105(8):
3278 - 3285.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Jin, F. Gao, T. Flagg, and X. Deng
Nicotine Induces Multi-site Phosphorylation of Bad in Association with Suppression of Apoptosis
J. Biol. Chem.,
May 28, 2004;
279(22):
23837 - 23844.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Osborn, P. L. Ryan, N. Kirchhof, A. Panoskaltsis-Mortari, F. Mortari, and K.-S. R. S. Tudor
Overexpression of murine TSLP impairs lymphopoiesis and myelopoiesis
Blood,
February 1, 2004;
103(3):
843 - 851.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Mulroy, Y. Xu, and J. M. Sen
{beta}-Catenin expression enhances generation of mature thymocytes
Int. Immunol.,
December 1, 2003;
15(12):
1485 - 1494.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Mai, W. S. May, F. Gao, Z. Jin, and X. Deng
A Functional Role for Nicotine in Bcl2 Phosphorylation and Suppression of Apoptosis
J. Biol. Chem.,
January 10, 2003;
278(3):
1886 - 1891.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Xue, F. Chu, Y. Cheng, X. Sun, A. Borthakur, M. Ramarao, P. Pandey, M. Wu, S. F. Schlossman, and K. V. S. Prasad
Siva-1 binds to and inhibits BCL-XL-mediated protection against UV radiation-induced apoptosis
PNAS,
May 14, 2002;
99(10):
6925 - 6930.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Rossiter, S. Beissert, C. Mayer, M. P. Schön, B. G. Wienrich, E. Tschachler, and T. S. Kupper
Targeted Expression of bcl-2 to Murine Basal Epidermal Keratinocytes Results in Paradoxical Retardation of Ultraviolet- and Chemical-induced Tumorigenesis
Cancer Res.,
May 1, 2001;
61(9):
3619 - 3626.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
K. Tsukasaki, C. W. Miller, T. Kubota, S. Takeuchi, T. Fujimoto, S. Ikeda, M. Tomonaga, and H. P. Koeffler
Tumor Necrosis Factor {{alpha}} Polymorphism Associated with Increased Susceptibility to Development of Adult T-Cell Leukemia/Lymphoma in Human T-lymphotropic Virus Type 1 Carriers
Cancer Res.,
May 1, 2001;
61(9):
3770 - 3774.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
C.-W. Chiang, G. Harris, C. Ellig, S. C. Masters, R. Subramanian, S. Shenolikar, B. E. Wadzinski, and E. Yang
Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation
Blood,
March 1, 2001;
97(5):
1289 - 1297.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M. Knudson, G. M. Johnson, Y. Lin, and S. J. Korsmeyer
Bax Accelerates Tumorigenesis in p53-deficient Mice
Cancer Res.,
January 1, 2001;
61(2):
659 - 665.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
G. Gomez, K. Z. Clarkin, E. Kraig, A. J. Infante, and E. R. Richie
TCR V{beta} repertoire restriction and lack of CDR3 conservation implicate TCR-superantigen interactions in promoting the clonal evolution of murine thymic lymphomas
Int. Immunol.,
March 1, 2000;
12(3):
263 - 270.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. K. Srivastava, C. Y. Sasaki, J. M. Hardwick, and D. L. Longo
Bcl-2-Mediated Drug Resistance: Inhibition of Apoptosis by Blocking Nuclear Factor of Activated T Lymphocytes (Nfat)-Induced FAS Ligand Transcription
J. Exp. Med.,
July 19, 1999;
190(2):
253 - 266.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Krosl, G. He, M. Lefrancois, F. Charron, P.-H. Romeo, P. Jolicoeur, I. R. Kirsch, M. Nemer, and T. Hoang
Transcription Factor SCL Is Required for c-kit Expression and c-Kit Function in Hemopoietic Cells
J. Exp. Med.,
August 3, 1998;
188(3):
439 - 450.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Virgilio, C. Lazzeri, R. Bichi, K.-i. Nibu, M. G. Narducci, G. Russo, J. L. Rothstein, and C. M. Croce
Deregulated expression of TCL1 causes T cell leukemia in mice
PNAS,
March 31, 1998;
95(7):
3885 - 3889.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. L. Grimes, C. B. Gilks, T. O. Chan, S. Porter, and P. N. Tsichlis
The Gfi-1 protooncoprotein represses Bax expression and inhibits T-cell death
PNAS,
December 10, 1996;
93(25):
14569 - 14573.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Jiang and E. Zacksenhaus
Activation of retinoblastoma protein in mammary gland leads to ductal growth suppression, precocious differentiation, and adenocarcinoma
J. Cell Biol.,
January 7, 2002;
156(1):
185 - 198.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
