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Delineation of an immunodominant and human T-cell lymphotropic virus
(HTLV)-specific epitope within the HTLV-I transmembrane glycoprotein
KG Hadlock, CJ Goh, PA Bradshaw, S Perkins, J Lo, JE Kaplan, R Khabbaz and SK Foung
Department of Molecular Virology, Genelabs Technologies, Inc. Redwood City,
CA 94063, USA.
Antibody reactivity to the transmembrane region of human T-cell
lymphotropic virus type I (HTLV-I) envelope, gp21, is observed in virtually
all individuals infected with HTLV-I or HTLV-II. Recombinant proteins
encoding selected portions of gp21 are described and used to define two
immunogenic regions. The first epitope (designated GD21-I) contains amino
acids 361 to 404 of the HTLV-I envelope and reacted with all of 54 sera
from HTLV-I- and HTLV-II-infected individuals. The second epitope
(designated BA21) expresses amino acids 397 to 430 of the HTLV-I envelope
and was recognized by 33 of 54 HTLV antisera. To determine the specificity
of GD21-I and BA21, sera from 17 HTLV- negative individuals with
nonspecific reactivity to p21E were tested. None of these sera reacted with
GD21-I, but 16 of 17 sera reacted with BA21. With virtually complete
reactivity to sera from HTLV-infected individuals and no reactivity to sera
from p21E-reactive uninfected individuals, GD21-I will be useful in
immunoassays for the detection of HTLV infection.
Volume 86,
Issue 4,
pp. 1392-1399,
08/15/1995
Copyright © 1995 by The American Society of Hematology
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