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Protective effect of granulocyte colony-stimulating factor against T-
cell-meditated lethal shock triggered by superantigens
Y Aoki, K Hiromatsu, N Kobayashi, T Hotta, H Saito, H Igarashi, Y Niho and Y Yoshikai
Laboratory of Host Defense, Nagoya University School of Medicine, Japan.
The bacterial superantigens (SAg), toxic shock syndrome toxin-1 (TSST- 1)
and staphylococcal enterotoxin B (SEB), are powerful T-cell stimulators,
triggering systemic release of lymphokines causing lethal shock in
D-galactosamine (D-Gal)-sensitized mice. We show that pretreatment with
recombinant human granulocyte colony-stimulating factor (rhG-CSF) protects
mice against T-cell-mediated SAg-shock. In mice challenged with
D-Gal/TSST-1, lethal shock was caused within 30 hours. In contrast, animals
pretreated with two consecutive subcutaneous injections of 2 micrograms
rhG-CSF with a 12-hour time interval showed only marginal signs of illness
and no lethality after challenge with D-Gal/TSST-1. Mice treated with 5
micrograms rhG-CSF either 12 or 6 hours in advance also survived otherwise
lethal doses of D-Gal/TSST-1. The protective effects of rhG-CSF
pretreatment was also evident against lethal doses of D-Gal/SEB challenge
and this protection was accompanied by suppression of systemic
interleukin-2. However, rhG- CSF affected neither the proliferative
responses of SAg-reactive T cells in vivo or in vitro nor their
interleukin-2 production in vitro, implying that rhG-CSF may indirectly
interfere with cytokine synthesis in T cells but not with T-cell-SAg
binding itself. These results represent another beneficial effect of
rhG-CSF as an anti-inflammatory agent against T-cell-mediated toxicity
triggered by SAg.
Volume 86,
Issue 4,
pp. 1420-1427,
08/15/1995
Copyright © 1995 by The American Society of Hematology
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