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Receptors for interleukin-3 (IL-3) and growth hormone mediate an IL-6- type
transcriptional induction in the presence of JAK2 or STAT3
Y Wang, KK Morella, J Ripperger, CF Lai, DP Gearing, GH Fey, SP Campos and H Baumann
Department of Molecular and Cellular Biology, Roswell Park Cancer
Institute, Buffalo, NY 14263, USA.
To determine the specificity of signal transducer and activator of
transcription (STAT) protein activation by box 3 motif-deficient
hematopoietin receptors, expression vectors encoding the receptors for
growth hormone, interleukin-3 (IL-3), and IL-4 were transiently transfected
into COS-1 cells, together with expression vectors for Janus kinases (JAKs)
and STAT proteins. Each receptor mediated a dose- dependent activation of
STAT1 and STAT3, and for IL-3R and GHR this process was enhanced by JAK2.
The data suggest that a box 3 motif in the cytoplasmic domain of the
signal-transducing receptor to the JAK/STAT pathway. Transfection of the
receptors, in combination with STAT3, into HepG2 cells reconstituted a
cytokine-dependent stimulation of gene transcription through IL-6 response
elements, providing evidence for a functional role of STAT3 in controlling
gene expression.
Volume 86,
Issue 5,
pp. 1671-1679,
09/01/1995
Copyright © 1995 by The American Society of Hematology
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