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The t(10;11) translocation in acute myeloid leukemia (M5) consistently
fuses the leucine zipper motif of AF10 onto the HRX gene
T Chaplin, O Bernard, HB Beverloo, V Saha, A Hagemeijer, R Berger and BD Young
Imperial Cancer Research Fund, Department of Medical Oncology, St
Bartholomew's Hospital Medical College, London, UK.
The gene on chromosome 10 at band p12 (AF10), involved in the t(10;11)
translocation in acute myeloid leukemia, has been identified and shown to
contain conserved zinc finger and leucine zipper domains. These regions are
highly homologous to the equivalent regions on AF17, the gene involved in
the t(11;17) translocations. A series of adult, childhood, and infant
leukemias with either simple or complex versions of the t(10;11) has been
examined by Southern analysis and shown to involve rearrangement to the HRX
locus. Reverse transcriptase- polymerase chain reaction from either bone
marrow or peripheral blood cells showed that HRX sequence was fused to AF10
sequence in all 8 cases and subsequent sequence analysis showed an in-frame
fusion between the HRX and AF10 sequence. A consistent feature of these
fusions was the juxtaposition of the leucine dimerization motif of AF10
onto the NH2-terminal region of HRX. The published data suggest that a
similar conclusion can be drawn about the t(11;17) translocation, implying
a critical role for this motif in the chimaeric HRX protein.
Volume 86,
Issue 6,
pp. 2073-2076,
09/15/1995
Copyright © 1995 by The American Society of Hematology
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