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The ski/sno protooncogene family in hematopoietic development
S Pearson-White, D Deacon, R Crittenden, G Brady, N Iscove and PJ Quesenberry
Department of Pediatrics, University of Virginia, Charlottesville, USA.
The ski/sno protooncogenes encode nuclear proteins that may act as
transcription factors. We examined ski and sno mRNA expression in
hemolymphopoietic lineages. The ski protooncogene is expressed in B- and
T-lineage cells, mature macrophages, and mast cells. In normal murine
marrow-derived progenitors analyzed by single-cell reverse
transcription-polymerase chain reaction (RT-PCR), ski expression is limited
to dual-lineage megakaryocyte/erythrocyte colony-starts. Expression of sno
is more limited than ski in mature cells; it is expressed in T
lymphopoietic cells, but not in B-lineage cells. The sno protooncogene is
expressed more widely than ski in myeloid progenitors, as it is found
consistently in tri-, dual-, and single-lineage progenitors. Both ski and
sno are cell cycle-regulated in synchronized factor-dependent mouse myeloid
cells. Expression of ski mRNA peaks in mid G1 in cells synchronized by
isoleucine deprivation in the presence of growth factor, but falls off
rapidly when growth factor is withdrawn. Expression of sno mRNA is maximal
in early to mid G1 and then oscillates as the cells continue through cycle.
These results suggest that the ski/sno protooncogenes play a role in
hematopoiesis, growth factor responses, and cell cycle-regulation, with the
two members of the family showing differing properties.
Volume 86,
Issue 6,
pp. 2146-2155,
09/15/1995
Copyright © 1995 by The American Society of Hematology
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