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Clonal relationship between lymphocytic predominance Hodgkin's disease and
concurrent or subsequent large-cell lymphoma of B lineage
RS Wickert, DD Weisenburger, A Tierens, TC Greiner and WC Chan
Department of Pathology and Microbiology, University of Nebraska Medical
Center, Omaha 68198-3135, USA.
The occurrence of a large-cell lymphoma (LCL) concurrent with or subsequent
to lymphocytic predominance Hodgkin's disease (LPHD) is well documented.
Given the well-characterized B-cell nature of the Reed- Sternberg cell
variants in LPHD, there may be a clonal relationship between the LPHD and
the associated B-cell LCL. In this study, we adapted a highly sensitive,
clonospecific assay to test whether the clone comprising the LCL exists in
the corresponding LPHD tumor. Nine cases meeting the histologic criteria of
nodular LPHD and B-cell LCL were identified, reviewed, and studied.
Initially, clonality of both lesions was assessed using consensus primers
to conserved regions in the IgH variable (frame-work III) and joining
region genes in a polymerase chain reaction (PCR) assay. The PCR assay
detected a clonal B-cell population in five of the LCLs, whereas analysis
of eight cases of LPHD did not detect a dominant clone. Clonal products
from the LCL were then sequenced, and clonospecific oligonucleotides were
designed from the unique nucleotide sequence encoding the complementarity-
determining region-III. These were then used as primers and/or probes in
sensitive PCR-based assays on the corresponding LPHD tumors. In two cases,
the clonospecific assay showed that the LPHD and LCL shared a common clone
that was further confirmed by sequence analysis. This finding provides
genotypic evidence that, at least in some cases, the LCL represents a
clonal progression of LPHD.
Volume 86,
Issue 6,
pp. 2312-2320,
09/15/1995
Copyright © 1995 by The American Society of Hematology
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