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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cesarman, E Articles by Chang, Y Search for Related Content PubMed PubMed Citation Articles by Cesarman, E Articles by Chang, Y Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences E Cesarman, PS Moore, PH Rao, G Inghirami, DM Knowles and Y Chang Department of Pathology, New York Hospital-Cornell Medical Center, New York 10021, USA. Two unique DNA fragments were recently identified in over 90% of acquired immunodeficiency syndrome (AIDS)-related Kaposi's sarcoma tissues. Sequence analysis suggests that these fragments belong to a previously unidentified human herpesvirus, Kaposi's sarcoma-associated herpesvirus (KSHV). These fragments have also been identified in a subset of non-Hodgkin's lymphomas in human immunodeficiency virus- positive patients; specifically, in body cavity-based lymphomas (AIDS- BCBLs). We have established two cell lines derived from AIDS-BCBLs, BC- 1 and BC-2, which retain the KSHV sequences, and have used them to further characterize this putative viral genome. In this report, we demonstrate that the KSHV sequences represent a portion of a much larger DNA molecule that is located predominantly in the nucleus of the infected cells. In situ hybridization of metaphase spreads made from both of these cell lines show these sequences in episomal structures. Their presence in the cells as large nuclear episomes supports previous sequence homology data suggesting that KSHV belongs to the herpesvirus family. These cell lines provide a continuous source of KSHV sequences. Thus, they represent an important tool for future studies of this recently described human herpesvirus that may be involved in the pathogenesis of Kaposi's sarcoma and some AIDS-related non-Hodgkin's lymphomas. Volume 86, Issue 7, pp. 2708-2714, 10/01/1995 Copyright © 1995 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B. Kelley-Clarke, E. De Leon-Vazquez, K. Slain, A. J. Barbera, and K. M. Kaye Role of Kaposi's Sarcoma-Associated Herpesvirus C-Terminal LANA Chromosome Binding in Episome Persistence J. Virol., May 1, 2009; 83(9): 4326 - 4337. [Abstract] [Full Text] [PDF] H.-J. Wen, V. Minhas, and C. 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Robertson Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Up-Regulates Transcription of Human Telomerase Reverse Transcriptase Promoter through Interaction with Transcription Factor Sp1 J. Virol., October 1, 2004; 78(19): 10348 - 10359. [Abstract] [Full Text] [PDF] E. Ohsaki, K. Ueda, S. Sakakibara, E. Do, K. Yada, and K. Yamanishi Poly(ADP-Ribose) Polymerase 1 Binds to Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Terminal Repeat Sequence and Modulates KSHV Replication in Latency J. Virol., September 15, 2004; 78(18): 9936 - 9946. [Abstract] [Full Text] [PDF] Y. Wang, H. Li, M. Y. Chan, F. X. Zhu, D. M. Lukac, and Y. Yuan Kaposi's Sarcoma-Associated Herpesvirus ori-Lyt-Dependent DNA Replication: cis-Acting Requirements for Replication and ori-Lyt-Associated RNA Transcription J. Virol., August 15, 2004; 78(16): 8615 - 8629. [Abstract] [Full Text] [PDF] M. R. Staudt, Y. Kanan, J. H. Jeong, J. F. Papin, R. Hines-Boykin, and D. P. 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Zhou Productive Lytic Replication of a Recombinant Kaposi's Sarcoma-Associated Herpesvirus in Efficient Primary Infection of Primary Human Endothelial Cells J. Virol., September 15, 2003; 77(18): 9738 - 9749. [Abstract] [Full Text] [PDF] S. E. Wang, F. Y. Wu, Y. Yu, and G. S. Hayward CCAAT/Enhancer-Binding Protein-{alpha} Is Induced during the Early Stages of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Lytic Cycle Reactivation and Together with the KSHV Replication and Transcription Activator (RTA) Cooperatively Stimulates the Viral RTA, MTA, and PAN Promoters J. Virol., September 1, 2003; 77(17): 9590 - 9612. [Abstract] [Full Text] [PDF] G. Gaidano, L. Pasqualucci, D. Capello, E. Berra, C. Deambrogi, D. Rossi, L. Maria Larocca, A. Gloghini, A. Carbone, and R. Dalla-Favera Aberrant somatic hypermutation in multiple subtypes of AIDS-associated non-Hodgkin lymphoma Blood, September 1, 2003; 102(5): 1833 - 1841. [Abstract] [Full Text] [PDF] N. Inoue, J. Winter, R. B. Lal, M. K. 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Sun Transcriptional Regulation of the Interleukin-6 Gene of Human Herpesvirus 8 (Kaposi's Sarcoma-Associated Herpesvirus) J. Virol., August 15, 2002; 76(16): 8252 - 8264. [Abstract] [Full Text] [PDF] D. P. AuCoin, K. S. Colletti, Y. Xu, S. A. Cei, and G. S. Pari Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Contains Two Functional Lytic Origins of DNA Replication J. Virol., August 1, 2002; 76(15): 7890 - 7896. [Abstract] [Full Text] [PDF] D. V. Ablashi, L. G. Chatlynne, J. E. Whitman Jr., and E. Cesarman Spectrum of Kaposi's Sarcoma-Associated Herpesvirus, or Human Herpesvirus 8, Diseases Clin. Microbiol. Rev., July 1, 2002; 15(3): 439 - 464. [Abstract] [Full Text] [PDF] F.-C. Zhou, Y.-J. Zhang, J.-H. Deng, X.-P. Wang, H.-Y. Pan, E. Hettler, and S.-J. Gao Efficient Infection by a Recombinant Kaposi's Sarcoma-Associated Herpesvirus Cloned in a Bacterial Artificial Chromosome: Application for Genetic Analysis J. Virol., June 15, 2002; 76(12): 6185 - 6196. 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Gourru, A. Sergeant, and H. Gruffat Identification of a short amino acid sequence essential for efficient nuclear targeting of the Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 K8 protein J. Gen. Virol., March 1, 2001; 82(3): 507 - 512. [Abstract] [Full Text] F. Y. Wu, J.-H. Ahn, D. J. Alcendor, W.-J. Jang, J. Xiao, S. D. Hayward, and G. S. Hayward Origin-Independent Assembly of Kaposi's Sarcoma-Associated Herpesvirus DNA Replication Compartments in Transient Cotransfection Assays and Association with the ORF-K8 Protein and Cellular PML J. Virol., February 1, 2001; 75(3): 1487 - 1506. [Abstract] [Full Text] [PDF] R. G. Jenner, M. M. Alba, C. Boshoff, and P. Kellam Kaposi's Sarcoma-Associated Herpesvirus Latent and Lytic Gene Expression as Revealed by DNA Arrays J. Virol., January 15, 2001; 75(2): 891 - 902. [Abstract] [Full Text] [PDF] S. Topino, L. Vincenzi, I. Mezzaroma, E. Nicastri, M. Andreoni, and M. C. 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Human Herpesvirus 8 Open Reading Frame 26 and Open Reading Frame 65 Sequences from Multiple Myeloma Patients: A Shared Pattern Not Found in Kaposi's Sarcoma or Primary Effusion Lymphoma Clin. Cancer Res., November 1, 2000; 6(11): 4226 - 4233. [Abstract] [Full Text] [PDF] A. Krithivas, D. B. Young, G. Liao, D. Greene, and S. D. Hayward Human Herpesvirus 8 LANA Interacts with Proteins of the mSin3 Corepressor Complex and Negatively Regulates Epstein-Barr Virus Gene Expression in Dually Infected PEL Cells J. Virol., October 15, 2000; 74(20): 9637 - 9645. [Abstract] [Full Text] [PDF] J. Chen, K. Ueda, S. Sakakibara, T. Okuno, and K. Yamanishi Transcriptional Regulation of the Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor Gene J. Virol., September 15, 2000; 74(18): 8623 - 8634. [Abstract] [Full Text] [PDF] Y. Aoki, R. Yarchoan, J. Braun, A. Iwamoto, and G. 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