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Developmental biology of hematopoiesis
LI Zon
Division of Hematology, Children's Hospital, Boston, MA 02115, USA.
The cellular and environmental regulation of hematopoiesis has been
generally conserved throughout vertebrate evolution, although subtle
species differences exist. The factors that regulate hematopoietic stem
cell homeostasis may closely resemble the inducers of embryonic patterning,
rather than the factors that stimulate hematopoietic cell proliferation and
differentiation. Comparative study of embryonic hematopoiesis in lower
vertebrates can generate testable hypotheses that similar mechanisms occur
during hematopoiesis in higher species.
Volume 86,
Issue 8,
pp. 2876-2891,
10/15/1995
Copyright © 1995 by The American Society of Hematology
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