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Idiotype-reactive T-cell subsets and tumor load in monoclonal gammopathies
Q Yi, A Osterborg, S Bergenbrant, H Mellstedt, G Holm and AK Lefvert
Immunological Research Laboratory, Karolinska Hospital, Stockholm, Sweden.
The presence of idiotype-reactive T-cell subsets and their relation to the
tumor load were analyzed in 9 patients with monoclonal gammopathy of
undetermined significance (MGUS), in 12 patients with multiple myeloma (MM)
clinical stage I, and in 9 patients with MM stage II/III. An enzyme-linked
immunospot assay was used to identify interferon-gamma (IFN-gamma)-,
interleukin-2 (IL-2)-, or IL-4-secreting T cells after stimulation by
F(ab')2 fragments of monoclonal IgG. The response to autologous IgG was
significantly higher than that induced by isotypic monoclonal IgG.
Comparable results were obtained in a proliferation assay (3H-thymidine
incorporation). A total of 8 of 9 patients with MGUS, 7 of 12 patients with
MM stage I, and 3 of 9 with MM stage II/III had T cells secreting IFN-gamma
and/or IL-2 (T helper [Th1] type-1 cells), whereas cells secreting both Th1
and Th2 or Th0 types of cytokines were more frequent in patients with MM,
particularly in those with MM stage II/III. The number and frequency of
Th1-type cells were significantly higher in MGUS patients as compared with
those of MM stage II/III. The results indicate that idiotype-reactive T
cells of the Th1 and Th2 or Th0 subsets were present in MGs and might
provide indirect evidence that idiotype-reactive Th1-type cells may have a
regulatory impact on the human tumor B cells.
Volume 86,
Issue 8,
pp. 3043-3049,
10/15/1995
Copyright © 1995 by The American Society of Hematology
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