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Preferential use of the VH4 Ig gene family by diffuse large-cell lymphoma
FJ Hsu and R Levy
Department of Medicine, Stanford University School of Medicine, CA, USA.
Ig heavy chain variable region (VH) genes expressed by human diffuse
large-cell lymphoma (DLC) and follicular lymphoma (FL) were identified and
analyzed with respect to germline gene families. In 67 cases of FL, VH
region genes were expressed in a pattern similar to that of normal B cells,
with a predominance of the large VH3 gene family being used. In contrast,
of the 17 cases of DLC, there was an extremely biased use of VH genes. Of
these DLC tumors, 88% expressed genes from the small VH4 gene family; and
even among these tumors, there was a limited use of genes, with 11 cases
producing Igs derived from the VH4.21 germline gene. Although most of the
VH genes expressed by DLC tumor cells contained mutations with respect to
their germline counterparts, almost all of these mutations occurred before
the clonal expansion of the tumor. This contrasts with our previous
findings of ongoing mutations in FL and represents a fundamental difference
between these two malignancies. This preferential gene use implies an
important role for the VH4 gene family, and specifically for VH4.21, in the
genesis of DLC.
Volume 86,
Issue 8,
pp. 3072-3082,
10/15/1995
Copyright © 1995 by The American Society of Hematology
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