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A distinct pattern of cytokine gene expression by human CD83+ blood
dendritic cells
LJ Zhou and TF Tedder
Department of Immunology, Duke University Medical Center, Durham, NC 27710,
USA.
Dendritic cells are the most potent antigen-presenting cells of the immune
system. Although dendritic cells are likely to secrete selective cytokines
that facilitate antigen presentation, the difficulty in isolating pure
dendritic cells in sufficient numbers has made assessment of this function
imprecise. In this study, pure populations of CD83+ human blood dendritic
cells were isolated by previously established enrichment procedures and
subsequent cell sorting. Cytokine gene expression was assessed by reverse
transcription-polymerase chain reaction (RT-PCR) amplification of mRNA.
Resting CD83+ dendritic cells expressed interleukin-6 (IL-6), IL-8, IL-10,
tumor necrosis factor- alpha (TNF-alpha), and transforming growth
factor-beta 1 (TGF-beta 1) mRNA, while activation of cells with phorbol
myristate acetate induced IL-1 alpha and beta, IL-9, TNF-beta,
interferon-gamma, granulocyte- macrophage colony-stimulating factor
(GM-CSF), M-CSF, and G-CSF mRNA expression. Resting CD83+ cells also
expressed the Rantes, MCP-1, MIP-1 alpha, and MIP-1 beta chemokines, with
1-309 expression induced upon activation. Resting and activated CD83+
dendritic cells also expressed receptors for IL-2 (CD25), TGF-beta 1 and
-beta 3, and GM-CSF as determined by indirect immunofluorescence staining.
These results indicate that dendritic cells have the ability to produce a
variety of soluble factors which are likely to contribute substantially to
the potent allostimulatory activity of these cells.
Volume 86,
Issue 9,
pp. 3295-3301,
11/01/1995
Copyright © 1995 by The American Society of Hematology
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