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Critical role of CD28/B7 costimulation in the development of human Th2
cytokine-producing cells
LM Webb and M Feldmann
Kennedy Institute of Rheumatology, Sunley Division, Hammersmith, London,
UK.
CD28 is a major costimulatory signal receptor for T cells. We have used
human naive CD4+ cells from cord blood to analyze the effect of the CD28/B7
costimulatory pathway on development of T helper (Th) subsets. We show that
CD28 costimulation is critical for development of the Th2
cytokine-producing cells and that in the absence of CD28 costimulation,
cells are not primed to produce Th2 cytokines and consequently "default" to
the Th1 subset, independent of the presence of exogenous cytokines. After
CD28 costimulation, cells differentiate into a subset that produces Th2
cytokines. However, further CD28 costimulation is not required to maintain
Th2 cytokine production. We conclude that D28 costimulation is critical for
the development of Th0 and Th2 subsets, but not for the maintenance of
cytokine production.
Volume 86,
Issue 9,
pp. 3479-3486,
11/01/1995
Copyright © 1995 by The American Society of Hematology
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