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Rolling in P-selectin-deficient mice is reduced but not eliminated in the
dorsal skin
S Yamada, TN Mayadas, F Yuan, DD Wagner, RO Hynes, RJ Melder and RK Jain
Steele Laboratory, Department of Radiation Oncology, Massachusetts General
Hospital, Boston 02114, USA.
P-selectin-mediated rolling is believed to be important in the recruitment
of leukocytes to tissue after ischemia-reperfusion injury. The dorsal skin
chamber was used to examine differences in the rolling and stable adhesion
of circulating leukocytes in subcutaneous (SC) vessels of
P-selectin-deficient and age-matched wild-type mice, both under basal
conditions and after ischemia-reperfusion. Rolling in the postcapillary
venules in SC tissue of P-selectin-deficient mice was significantly lower
than that in wild-type mice under the basal conditions and
post-ischemia-reperfusion (P < .05), but was not eliminated by the
deletion of the P-selectin gene. No significant difference between
P-selectin-deficient and wild-type mice in shear rate or
leukocyte-endothelial adhesion was observed up to 24 hours after
ischemia-reperfusion. These results show that P-selectin-mediated rolling
is not a prerequisite for ischemia-reperfusion-induced
leukocyte-endothelial adhesion in the skin.
Volume 86,
Issue 9,
pp. 3487-3492,
11/01/1995
Copyright © 1995 by The American Society of Hematology
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