|
|
 Previous Article | Table of Contents | Next Article 
Regulated expression and function of CD122 (interleukin-2/interleukin-
15R-beta) during lymphoid development
T Reya, JA Yang-Snyder, EV Rothenberg and SR Carding
Department of Microbiology, University of Pennsylvania, Philadelphia
19104-6076, USA.
To determine whether signaling via CD122 (interleukin-2 [IL-2]/IL-15
receptor beta-chain) plays a role in regulating the expansion and
differentiation of lymphocyte precursors, we have characterized its
expression and evaluated its ability to influence the activity of
developing lymphoid cells. A significant fraction of Sca1+Lin-
hematopoietic stem cells in day 12 fetal liver were found to be CD122+.
CD122-mRNA+ and IL-2-mRNA+ cells were also localized in embryo sections
within pharyngeal blood vessels adjacent to and surrounding the thymic
analgen. This distribution is consistent with the migration of CD122+
progenitor cells from the liver to the developing thymus where a majority
of Sca1+ intrathymic T-cell progenitors were CD122+. Analysis of CD122
expression in the day 12 fetal liver revealed that the majority of B220+
cells were CD122+. Furthermore, CD122 expression was restricted to the
earliest B220+ cells (CD43+CD24-; prepro B cells; fraction A) that
proliferate vigorously to IL-2 in the absence of any stromal cells, but not
to IL-15. Consistent with a role for the IL-2/IL- 2R pathway in lymphocyte
development is the progressive loss of B cells seen in IL-2-deficient mice.
Together, these observations suggest that CD122 plays a role in regulating
normal lymphocyte development in vivo.
Volume 87,
Issue 1,
pp. 190-201,
01/01/1996
Copyright © 1996 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
J.-H. Cho, O. Boyman, H.-O. Kim, B. Hahm, M. P. Rubinstein, C. Ramsey, D. M. Kim, C. D. Surh, and J. Sprent
An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2
J. Exp. Med.,
August 6, 2007;
204(8):
1787 - 1801.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Alpdogan, J. M. Eng, S. J. Muriglan, L. M. Willis, V. M. Hubbard, K. H. Tjoe, T. H. Terwey, A. Kochman, and M. R. M. van den Brink
Interleukin-15 enhances immune reconstitution after allogeneic bone marrow transplantation
Blood,
January 15, 2005;
105(2):
865 - 873.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Ikawa, K. Masuda, M. Lu, N. Minato, Y. Katsura, and H. Kawamoto
Identification of the earliest prethymic T-cell progenitors in murine fetal blood
Blood,
January 15, 2004;
103(2):
530 - 537.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. O. Porter and T. R. Malek
IL-2R{beta}/IL-7R{alpha} Doubly Deficient Mice Recapitulate the Thymic and Intraepithelial Lymphocyte (IEL) Developmental Defects of {gamma}c-/- Mice: Roles for Both IL-2 and IL-15 in CD8{alpha}{alpha} IEL Development
J. Immunol.,
December 1, 1999;
163(11):
5906 - 5912.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Reya, N. V. Contractor, M. S. Couzens, M. A. Wasik, S. G. Emerson, and S. R. Carding
Abnormal Myelocytic Cell Development in Interleukin-2 (IL-2)-Deficient Mice: Evidence for the Involvement of IL-2 in Myelopoiesis
Blood,
April 15, 1998;
91(8):
2935 - 2947.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Nakayama, I. Fang, and G. Elliott
Natural Killer and B-Lymphoid Potential in CD34+ Cells Derived From Embryonic Stem Cells Differentiated in the Presence of Vascular Endothelial Growth Factor
Blood,
April 1, 1998;
91(7):
2283 - 2295.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. Carlyle, A. M. Michie, S. K. Cho, and J. C. Zuniga-Pflucker
Natural Killer Cell Development and Function Precede {alpha}{beta} T Cell Differentiation in Mouse Fetal Thymic Ontogeny
J. Immunol.,
January 15, 1998;
160(2):
744 - 753.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. V. Contractor, H. Bassiri, T. Reya, A. Y. Park, D. C. Baumgart, M. A. Wasik, S. G. Emerson, and S. R. Carding
Lymphoid Hyperplasia, Autoimmunity, and Compromised Intestinal Intraepithelial Lymphocyte Development in Colitis-Free Gnotobiotic IL-2-Deficient Mice
J. Immunol.,
January 1, 1998;
160(1):
385 - 394.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
