|
|
 Previous Article | Table of Contents | Next Article 
Aorta-associated CD34+ hematopoietic cells in the early human embryo
M Tavian, L Coulombel, D Luton, HS Clemente, F Dieterlen-Lievre and B Peault
Institut d'Embryologie Cellulaire et Moleculaire du CNRS et du College de
France, CNRS UMR 9924, France.
Hematopoiesis is established from circulating blood stem cells that seed
the embryonic rudiments of blood-forming tissues, a basic notion in
developmental hematology. However, the assumption that these stem cells
originate from the extraembryonic mesoderm, where primitive hematopoiesis
is initiated by intrinsic precursors, has been reconsidered after analysis
of blood cell development in avian embryo chimeras: yolk-sac-derived stem
cells do not contribute significantly to the definitive blood system, whose
first forerunners develop independently along the ventral aspect of the
embryonic aorta. Recently, the homologous intraembryonic tissues of the
mouse have been submitted to sensitive in vivo and in vitro assays, which
showed that they also harbor multipotential hematopoietic stem cells. We
have now identified a dense population of hematogenous cells, marked by the
surface expression of the CD34 glycoprotein, associated with the ventral
endothelium of the aorta in the 5-week human embryo. Therefore, we extend
to the human species the growing evidence that intraembryonic hematopoietic
cells developing independently of the yolk sac might be the real stem of
the whole blood system.
Volume 87,
Issue 1,
pp. 67-72,
01/01/1996
Copyright © 1996 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
A. Barcena, M. O. Muench, M. Kapidzic, and S. J. Fisher
A New Role for the Human Placenta as a Hematopoietic Site Throughout Gestation
Reproductive Sciences,
February 1, 2009;
16(2):
178 - 187.
[Abstract]
[PDF]
|
|
|
|
|
|
|
L. C. Goldie, J. L. Lucitti, M. E. Dickinson, and K. K. Hirschi
Cell signaling directing the formation and function of hemogenic endothelium during murine embryogenesis
Blood,
October 15, 2008;
112(8):
3194 - 3204.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Dzierzak and A. Medvinsky
The discovery of a source of adult hematopoietic cells in the embryo
Development,
July 15, 2008;
135(14):
2343 - 2346.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Qiu, E. N. Olivier, M. Velho, and E. E. Bouhassira
Globin switches in yolk sac-like primitive and fetal-like definitive red blood cells produced from human embryonic stem cells
Blood,
February 15, 2008;
111(4):
2400 - 2408.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X.-Y. Wang, Y. Lan, W.-Y. He, L. Zhang, H.-Y. Yao, C.-M. Hou, Y. Tong, Y.-L. Liu, G. Yang, X.-D. Liu, et al.
Identification of mesenchymal stem cells in aorta-gonad-mesonephros and yolk sac of human embryos
Blood,
February 15, 2008;
111(4):
2436 - 2443.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Taoudi and A. Medvinsky
Functional identification of the hematopoietic stem cell niche in the ventral domain of the embryonic dorsal aorta
PNAS,
May 29, 2007;
104(22):
9399 - 9403.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Y. I. Chan, G. A. Follows, G. Lacaud, J. E. Pimanda, J.-R. Landry, S. Kinston, K. Knezevic, S. Piltz, I. J. Donaldson, L. Gambardella, et al.
The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype
Blood,
March 1, 2007;
109(5):
1908 - 1916.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ema, T. Yokomizo, A. Wakamatsu, T. Terunuma, M. Yamamoto, and S. Takahashi
Primitive erythropoiesis from mesodermal precursors expressing VE-cadherin, PECAM-1, Tie2, endoglin, and CD34 in the mouse embryo
Blood,
December 15, 2006;
108(13):
4018 - 4024.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Galkina, A. Kadl, J. Sanders, D. Varughese, I. J. Sarembock, and K. Ley
Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent
J. Exp. Med.,
May 15, 2006;
203(5):
1273 - 1282.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Yokota, J. Huang, M. Tavian, Y. Nagai, J. Hirose, J.-C. Zuniga-Pflucker, B. Peault, and P. W. Kincade
Tracing the first waves of lymphopoiesis in mice
Development,
May 15, 2006;
133(10):
2041 - 2051.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Kogata, Y. Arai, J. T. Pearson, K. Hashimoto, K. Hidaka, T. Koyama, S. Somekawa, Y. Nakaoka, M. Ogawa, R. H. Adams, et al.
Cardiac Ischemia Activates Vascular Endothelial Cadherin Promoter in Both Preexisting Vascular Cells and Bone Marrow Cells Involved in Neovascularization
Circ. Res.,
April 14, 2006;
98(7):
897 - 904.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L Banaei-Bouchareb, M Peuchmaur, P Czernichow, and M Polak
A transient microenvironment loaded mainly with macrophages in the early developing human pancreas.
J. Endocrinol.,
March 1, 2006;
188(3):
467 - 480.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.-G. Kopp, S. T. Avecilla, A. T. Hooper, and S. Rafii
The Bone Marrow Vascular Niche: Home of HSC Differentiation and Mobilization
Physiology,
October 1, 2005;
20(5):
349 - 356.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Taoudi, A. M. Morrison, H. Inoue, R. Gribi, J. Ure, and A. Medvinsky
Progressive divergence of definitive haematopoietic stem cells from the endothelial compartment does not depend on contact with the foetal liver
Development,
September 15, 2005;
132(18):
4179 - 4191.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Hirai, I. M Samokhvalov, T. Fujimoto, S. Nishikawa, J. Imanishi, and S.-I. Nishikawa
Involvement of Runx1 in the down-regulation of fetal liver kinase-1 expression during transition of endothelial cells to hematopoietic cells
Blood,
September 15, 2005;
106(6):
1948 - 1955.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Doyonnas, J. S. Nielsen, S. Chelliah, E. Drew, T. Hara, A. Miyajima, and K. M. McNagny
Podocalyxin is a CD34-related marker of murine hematopoietic stem cells and embryonic erythroid cells
Blood,
June 1, 2005;
105(11):
4170 - 4178.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Gerecht-Nir, S. Osenberg, O. Nevo, A. Ziskind, R. Coleman, and J. Itskovitz-Eldor
Vascular Development in Early Human Embryos and in Teratomas Derived from Human Embryonic Stem Cells
Biol Reprod,
December 1, 2004;
71(6):
2029 - 2036.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Jiang, L. Walker, M. Afentoulis, D. A. Anderson, L. Jauron-Mills, C. L. Corless, and W. H. Fleming
Transplanted human bone marrow contributes to vascular endothelium
PNAS,
November 30, 2004;
101(48):
16891 - 16896.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Menier, M. Rabreau, J.-C. Challier, M. Le Discorde, E. D. Carosella, and N. Rouas-Freiss
Erythroblasts secrete the nonclassical HLA-G molecule from primitive to definitive hematopoiesis
Blood,
November 15, 2004;
104(10):
3153 - 3160.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. Gothert, S. E. Gustin, J. A. M. van Eekelen, U. Schmidt, M. A. Hall, S. M. Jane, A. R. Green, B. Gottgens, D. J. Izon, and C. G. Begley
Genetically tagging endothelial cells in vivo: bone marrow-derived cells do not contribute to tumor endothelium
Blood,
September 15, 2004;
104(6):
1769 - 1777.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Umeda, T. Heike, M. Yoshimoto, M. Shiota, H. Suemori, H. Y. Luo, D. H. K. Chui, R. Torii, M. Shibuya, N. Nakatsuji, et al.
Development of primitive and definitive hematopoiesis from nonhuman primate embryonic stem cells in vitro
Development,
April 15, 2004;
131(8):
1869 - 1879.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. S. Bailey, S. Jiang, M. Afentoulis, C. I. Baumann, D. A. Schroeder, S. B. Olson, M. H. Wong, and W. H. Fleming
Transplanted adult hematopoietic stems cells differentiate into functional endothelial cells
Blood,
January 1, 2004;
103(1):
13 - 19.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Alvarez-Silva, P. Belo-Diabangouaya, J. Salaun, and F. Dieterlen-Lievre
Mouse placenta is a major hematopoietic organ
Development,
November 15, 2003;
130(22):
5437 - 5444.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Chadwick, L. Wang, L. Li, P. Menendez, B. Murdoch, A. Rouleau, and M. Bhatia
Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells
Blood,
August 1, 2003;
102(3):
906 - 915.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Hirai, M. Ogawa, N. Suzuki, M. Yamamoto, G. Breier, O. Mazda, J. Imanishi, and S.-I. Nishikawa
Hemogenic and nonhemogenic endothelium can be distinguished by the activity of fetal liver kinase (Flk)-1 promoter/enhancer during mouse embryogenesis
Blood,
February 1, 2003;
101(3):
886 - 893.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Oberlin, M. Tavian, I. Blazsek, and B. Peault
Blood-forming potential of vascular endothelium in the human embryo
Development,
September 1, 2002;
129(17):
4147 - 4157.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Wilpshaar, E. C. Joekes, F. T. H. Lim, G. A. M. Van Leeuwen, P. J. Van den Boogaard, H. H. H. Kanhai, R. Willemze, and J. H. F. Falkenburg
Magnetic resonance imaging of fetal bone marrow for quantitative definition of the human fetal stem cell compartment
Blood,
June 28, 2002;
100(2):
451 - 457.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Lacaud, L. Gore, M. Kennedy, V. Kouskoff, P. Kingsley, C. Hogan, L. Carlsson, N. Speck, J. Palis, and G. Keller
Runx1 is essential for hematopoietic commitment at the hemangioblast stage of development in vitro
Blood,
June 28, 2002;
100(2):
458 - 466.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Wilpshaar, M. Bhatia, H. H. H. Kanhai, R. Breese, D. K. Heilman, C. S. Johnson, J. H. F. Falkenburg, and E. F. Srour
Engraftment potential of human fetal hematopoietic cells in NOD/SCID mice is not restricted to mitotically quiescent cells
Blood,
June 17, 2002;
100(1):
120 - 127.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Harder, R. Henschler, I. Junghahn, M. C. Lamers, and A. M. Muller
Human hematopoiesis in murine embryos after injecting human cord blood-derived hematopoietic stem cells into murine blastocysts
Blood,
January 15, 2002;
99(2):
719 - 721.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Campagnoli, I. A. G. Roberts, S. Kumar, P. R. Bennett, I. Bellantuono, and N. M. Fisk
Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow
Blood,
October 15, 2001;
98(8):
2396 - 2402.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Ohneda, K. Ohneda, F. Arai, J. Lee, T. Miyamoto, Y. Fukushima, D. Dowbenko, L. A. Lasky, and T. Suda
ALCAM (CD166): its role in hematopoietic and endothelial development
Blood,
October 1, 2001;
98(7):
2134 - 2142.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Blazsek, J. Chagraoui, and B. Peault
Ontogenic emergence of the hematon, a morphogenetic stromal unit that supports multipotential hematopoietic progenitors in mouse bone marrow
Blood,
December 1, 2000;
96(12):
3763 - 3771.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. J. Marshall, C. Kinnon, and A. J. Thrasher
Polarized expression of bone morphogenetic protein-4 in the human aorta-gonad-mesonephros region
Blood,
August 15, 2000;
96(4):
1591 - 1593.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Watt, L. H. Butler, M. Tavian, H.-J. Buhring, I. Rappold, P. J. Simmons, A. C. W. Zannettino, D. Buck, A. Fuchs, R. Doyonnas, et al.
Functionally defined CD164 epitopes are expressed on CD34+ cells throughout ontogeny but display distinct distribution patterns in adult hematopoietic and nonhematopoietic tissues
Blood,
May 15, 2000;
95(10):
3113 - 3124.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Campagnoli, N. Fisk, T. Overton, P. Bennett, T. Watts, and I. Roberts
Circulating hematopoietic progenitor cells in first trimester fetal blood
Blood,
March 15, 2000;
95(6):
1967 - 1972.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. G. Elefanty, C. G. Begley, L. Hartley, B. Papaevangeliou, and L. Robb
SCL Expression in the Mouse Embryo Detected With a Targeted lacZ Reporter Gene Demonstrates Its Localization to Hematopoietic, Vascular, and Neural Tissues
Blood,
December 1, 1999;
94(11):
3754 - 3763.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. W. Flake and E. D. Zanjani
In Utero Hematopoietic Stem Cell Transplantation: Ontogenic Opportunities and Biologic Barriers
Blood,
October 1, 1999;
94(7):
2179 - 2191.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Delassus, I. Titley, and T. Enver
Functional and Molecular Analysis of Hematopoietic Progenitors Derived From the Aorta-Gonad-Mesonephros Region of the Mouse Embryo
Blood,
September 1, 1999;
94(5):
1495 - 1503.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. G. Begley and A. R. Green
The SCL Gene: From Case Report to Critical Hematopoietic Regulator
Blood,
May 1, 1999;
93(9):
2760 - 2770.
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Ody, P. Vaigot, P. Quere, B. A. Imhof, and C. Corbel
Glycoprotein IIb-IIIa Is Expressed on Avian Multilineage Hematopoietic Progenitor Cells
Blood,
May 1, 1999;
93(9):
2898 - 2906.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Dunon, N. Allioli, O. Vainio, C. Ody, and B.A. Imhof
Quantification of T-Cell Progenitors During Ontogeny: Thymus Colonization Depends on Blood Delivery of Progenitors
Blood,
April 1, 1999;
93(7):
2234 - 2243.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Cortes, F. Deschaseaux, N. Uchida, M.-C. Labastie, A. M. Friera, D. He, P. Charbord, and B. Peault
HCA, an Immunoglobulin-Like Adhesion Molecule Present on the Earliest Human Hematopoietic Precursor Cells, Is Also Expressed by Stromal Cells in Blood-Forming Tissues
Blood,
February 1, 1999;
93(3):
826 - 837.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M Sanchez, B Gottgens, A. Sinclair, M Stanley, C. Begley, S Hunter, and A. Green
An SCL 3' enhancer targets developing endothelium together with embryonic and adult haematopoietic progenitors
Development,
January 9, 1999;
126(17):
3891 - 3904.
[Abstract]
[PDF]
|
|
|
|
|
|
|
T North, T. Gu, T Stacy, Q Wang, L Howard, M Binder, M Marin-Padilla, and N. Speck
Cbfa2 is required for the formation of intra-aortic hematopoietic clusters
Development,
January 6, 1999;
126(11):
2563 - 2575.
[Abstract]
[PDF]
|
|
|
|
|
|
|
L Pardanaud and F Dieterlen-Lievre
Manipulation of the angiopoietic/hemangiopoietic commitment in the avian embryo
Development,
January 2, 1999;
126(4):
617 - 627.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M Tavian, M. Hallais, and B Peault
Emergence of intraembryonic hematopoietic precursors in the pre-liver human embryo
Development,
January 2, 1999;
126(4):
793 - 803.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Lampisuo, J. Liippo, O. Vainio, K. M. McNagny, J. Kulmala, and O. Lassila
Characterization of prethymic progenitors within the chicken embryo
Int. Immunol.,
January 1, 1999;
11(1):
63 - 69.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.-C. Labastie, F. Cortes, P.-H. Romeo, C. Dulac, and B. Peault
Molecular Identity of Hematopoietic Precursor Cells Emerging in the Human Embryo
Blood,
November 15, 1998;
92(10):
3624 - 3635.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Ohneda, C. Fennie, Z. Zheng, C. Donahue, H. La, R. Villacorta, B. Cairns, and L. A. Lasky
Hematopoietic Stem Cell Maintenance and Differentiation Are Supported by Embryonic Aorta-Gonad-Mesonephros Region-Derived Endothelium
Blood,
August 1, 1998;
92(3):
908 - 919.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Verhasselt, M. De Smedt, R. Verhelst, E. Naessens, and J. Plum
Retrovirally Transduced CD34++ Human Cord Blood Cells Generate T Cells Expressing High Levels of the Retroviral Encoded Green Fluorescent Protein Marker In Vitro
Blood,
January 15, 1998;
91(2):
431 - 440.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T Jaffredo, R Gautier, A Eichmann, and F Dieterlen-Lievre
Intraaortic hemopoietic cells are derived from endothelial cells during ontogeny
Development,
January 11, 1998;
125(22):
4575 - 4583.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. Nishikawa, S Nishikawa, M Hirashima, N Matsuyoshi, and H Kodama
Progressive lineage analysis by cell sorting and culture identifies FLK1+VE-cadherin+ cells at a diverging point of endothelial and hemopoietic lineages
Development,
January 5, 1998;
125(9):
1747 - 1757.
[Abstract]
[PDF]
|
|
|
|
|
|
|
H. B. Wood, G. May, L. Healy, T. Enver, and G. M. Morriss-Kay
CD34 Expression Patterns During Early Mouse Development Are Related to Modes of Blood Vessel Formation and Reveal Additional Sites of Hematopoiesis
Blood,
September 15, 1997;
90(6):
2300 - 2311.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Zimmermann and I. N. Rich
Mammalian Homeobox B6 Expression Can Be Correlated With Erythropoietin Production Sites and Erythropoiesis During Development, But Not With Hematopoietic or Nonhematopoietic Stem Cell Populations
Blood,
April 15, 1997;
89(8):
2723 - 2735.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L Pardanaud, D Luton, M Prigent, L. Bourcheix, M Catala, and F Dieterlen-Lievre
Two distinct endothelial lineages in ontogeny, one of them related to hemopoiesis
Development,
January 5, 1996;
122(5):
1363 - 1371.
[Abstract]
[PDF]
|
|
|
|
|
