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Chemotactic and chemokinetic activities of stem cell factor on murine
hematopoietic progenitor cells
N Okumura, K Tsuji, Y Ebihara, I Tanaka, N Sawai, K Koike, A Komiyama and T Nakahata
Division of Clinical Chemistry and Medical Technology, School of Allied
Medical Sciences, Shinshu University, Matsumoto, Japan.
We investigated the effects of stem cell factor (SCF) on the migration of
murine bone marrow hematopoietic progenitor cells (HPC) in vitro using a
modification of the checkerboard assay. Chemotactic and chemokinetic
activities of SCF on HPC were evaluated by the numbers of HPC migrated on
positive and negative gradients of SCF, respectively. On both positive and
negative gradients of SCF, HPC began to migrate after 4 hours incubation,
and their numbers then increased time- dependently. These results indicated
that SCF functions as a chemotactic and chemokinetic agent for HPC.
Analysis of types of colonies derived from the migrated HPC showed that SCF
had chemotactic and chemokinetic effects on all types of HPC. When
migrating activities of other cytokines were examined, interleukin (IL)-3
and IL-11 also affected the migration of HPC, but the degrees of each
effect were lower than that of SCF. The results of the present study
demonstrated that SCF is one of the most potent chemotactic and
chemokinetic factors for HPC and suggest that SCF may play an important
role in the flow of HPC into bone marrow where stromal cells constitutively
produce SCF.
Volume 87,
Issue 10,
pp. 4100-4108,
05/15/1996
Copyright © 1996 by The American Society of Hematology
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