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A concurrent human herpesvirus-6 infection renders two human hematopoietic
progenitor (TF-1 and KG-1) cell lines susceptible to human immunodeficiency
virus type-1
G Furlini, M Vignoli, E Ramazzotti, MC Re, G Visani and Placa La
Institute of Microbiology of the University of Bologna, Italy.
In human immunodeficiency virus type-1 (HIV-1) infected individuals, CD34+
hematopoietic stem/progenitor cells are profoundly impaired in their
proliferation/differentiation capacities. The bulk of the available
experimental evidence seems to indicate that hematopoietic progenitors are
not susceptible to HIV-1 infection and their defects seem rather the
consequence of direct or indirect negative influences of HIV-1-specific
soluble proteins released by productively infected accessory cells. We have
now shown that in the presence of a concurrent human herpesvirus-6
infection, two hematopoietic (TF-1 [erythromyeloid] and KG-1
[lymphomyeloid]) progenitor cell lines and human CD34+ hematopoietic
progenitors isolated from the bone marrow of normal donors, became
susceptible to HIV-1 infection and permissive to HIV-1 replication,
although with a limited virus yield. These results suggest a further
possible mechanism leading to hematopoietic derangement in HIV-1-infected
subjects and may help to clarify the controversial issue of the
susceptibility of human hematopoietic progenitors to HIV-1 infection.
Volume 87,
Issue 11,
pp. 4737-4745,
06/01/1996
Copyright © 1996 by The American Society of Hematology
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