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Kaposi's sarcoma-associated herpesvirus (KSHV or HHV8) in primary effusion
lymphoma: ultrastructural demonstration of herpesvirus in lymphoma cells
W Said, K Chien, S Takeuchi, T Tasaka, H Asou, SK Cho, S de Vos, E Cesarman, DM Knowles and HP Koeffler
Department of Pathology, Cedars Sinai Medical Center, Los Angeles, CA
90048, USA.
Recent molecular evidence suggests an association with a new herpesvirus,
Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8), and primary effusion
lymphomas (PELs). PELs have a characteristic morphology, phenotype, and
clinical presentation, with malignant effusions in the absence of a
contiguous solid tumor mass. We have established a cell line (KS-1) from a
KSHV-positive human immunodeficiency virus (HIV)-negative patient with
pleural cavity-based lymphoma that was passaged into triple-immunodeficient
BNX mice. In contrast to cell lines from body cavity-based lymphomas
derived from HIV-positive individuals that contain both KSHV and Epstein
Barr viral genome, these cells contain only KSHV, allowing for
uncontaminated virologic studies. Ultrastructural examination identified
malignant cells with features of late differentiating B cells
(immunoblasts). Cells with viral cytopathic effect contained typical 110-nm
intranuclear herpesvirus nucleocapsids and complete cytoplasmic virions,
confirming the association of PEL with KSHV.
Volume 87,
Issue 12,
pp. 4937-4943,
06/15/1996
Copyright © 1996 by The American Society of Hematology
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