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Development of day-8 colony-forming unit-spleen hematopoietic progenitors
during early murine embryogenesis: spatial and temporal mapping
AL Medvinsky, OI Gan, ML Semenova and NL Samoylina
Laboratory of Physiology of Hematopoiesis, National Research Center for
Hematology, Mill Hill, London, UK.
The ontogeny of the hematopoietic system in mammalian embryos occurs during
the yolk sac (YS) and the fetal liver (FL) stages. Events leading to the
establishment of hematopoiesis in the FL remain obscure. The appearance of
colony-forming units-spleen (CFU-S) in the FL is preceded by a gradual
increase of CFU-S in the YS and a more rapid increase in the AGM region
(area comprising dorsal aorta, gonads, and mesonephros) during day 10 of
development (Medvinsky et al, Nature 364:64, 1993). By this time, the AGM
CFU-S attain a high frequency equivalent to that found in the adult bone
marrow. The analogous area gives rise to adult hematopoiesis in amphibians
and probably in birds. We present here a more complete picture of CFU-S
development during transition from the pre-liver to liver stage of
hematopoiesis. (1) Dissectional analysis of the mouse AGM region shows the
presence of CFU- S both around the dorsal aorta and in the uro-genital
ridges. (2) The embryonic gut also shows low but distinctive CFU-S
activity. This initial intrabody pattern of CFU-S distribution in murine
embryogenesis parallels that found for primordial germ cells. (3) The
beginning of definitive liver hematopoiesis is accompanied by wide
dissemination of CFU-S in the embryonic tissues. (4) Comparison of spleen
colonies arising from the AGM and YS has shown morphologic differences. In
contrast to simple erythroid constitution of the YS colonies, a broader
variety of cells are found within the AGM-derived colonies that are similar
to those derived from 11-day FL. These data suggest a lineage relationship
for hematopoietic progenitors between the AGM region and the FL.
Volume 87,
Issue 2,
pp. 557-566,
01/15/1996
Copyright © 1996 by The American Society of Hematology
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