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Effects of granulocyte colony-stimulating factor on plasma cytokine and
cytokine receptor levels and on the in vivo host response to endotoxin in
healthy men
T Pollmacher, C Korth, J Mullington, W Schreiber, J Sauer, H Vedder, C Galanos and F Holsboer
Max Planck Institute of Psychiatry, Department of Psychiatry, Munich,
Germany.
We investigated the effects of granulocyte colony-stimulating factor (G-
CSF) on cytokine and cytokine receptor plasma levels and on the in vivo
host response to Salmonella abortus equi endotoxin in healthy males. Twenty
volunteers received 0.8 ng/kg endotoxin and saline intravenously 1 week
apart in randomized order. Twelve hours before both experiments, 10 of
these subjects were pretreated with 300 micrograms G-CSF subcutaneously.
G-CSF itself increased granulocyte and monocyte counts and the plasma
levels of tumor necrosis factor-alpha (TNF-alpha), soluble TNF receptors
(sTNF-R) p55, and p75 and interleukin-1 receptor antagonist (IL-1ra). G-CSF
did not influence plasma IL-1 beta and IL-6 levels. In the G-CSF-pretreated
subjects endotoxin-induced surges in rectal temperature and in the plasma
levels of TNF-alpha plasma levels were about 50% increased, and surges in
the plasma levels of both sTNF- Rs and IL-1ra were about twice as high as
in the control group. Endotoxin-induced increases in IL-6, cortisol, and
heart rate were not modified by G-CSF pretreatment. Endotoxin
administration induced a transient 50% reduction in leukocyte counts in the
G-CSF-pretreated subjects that was not seen in the control group. We
conclude that a single stand dose of G-CSF increases the plasma levels of
cytokines and cytokine receptors and considerably modifies the host
response of healthy humans to a low dose of endotoxin.
Volume 87,
Issue 3,
pp. 900-905,
02/01/1996
Copyright © 1996 by The American Society of Hematology
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