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A1, a Bcl-2 family member, prolongs cell survival and permits myeloid
differentiation
EY Lin, A Orlofsky, HG Wang, JC Reed and MB Prystowsky
Department of Pathology, Albert Einstein College of Medicine, Bronx, NY
10467, USA.
A1, a bcl-2 family member, has been identified as a hematopoietic-
specific, early inducible gene. In this study it is shown that stable
transfection of A1 into an interleukin-3 (IL-3)-dependent myeloid precursor
cell line, 32D c13, leads to a retardation of IL-3 withdrawal- induced cell
death similar to that observed with transfection of bcl-2. However, unlike
bcl-2. A1 expression permits the accumulation of differentiated myeloid
cells both before and after IL-3 withdrawal. Total cell accumulation, on
the other hand, is considerably greater after IL-3 deprivation in the bcl-2
transfectant than in A1-expressing cells. Cells cotransfected with the two
genes behave similarly to cells singly transfected with bcl-2, except that
viability following IL-3 withdrawal is somewhat further enhanced. These
results suggest that these two proteins have distinct roles that may be
related to the divergent regulation of their expression during myeloid
differentiation.
Volume 87,
Issue 3,
pp. 983-992,
02/01/1996
Copyright © 1996 by The American Society of Hematology
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|
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|
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167(7):
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|
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|
|
|
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
|
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192(5):
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[Abstract]
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[PDF]
|
|
|
|
|
|
|
S. Y. Hsu and A. J. W. Hsueh
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April 1, 2000;
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[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. T. M. Leung, S. Morefield, and D. M. Willerford
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J. Immunol.,
April 1, 2000;
164(7):
3527 - 3534.
[Abstract]
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[PDF]
|
|
|
|
|
|
|
A. Gross, A. Terraza, S. Ouahrani-Bettache, J.-P. Liautard, and J. Dornand
In Vitro Brucella suis Infection Prevents the Programmed Cell Death of Human Monocytic Cells
Infect. Immun.,
January 1, 2000;
68(1):
342 - 351.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. M. Tomayko, J. A. Punt, J. M. Bolcavage, S. L. Levy, D. M. Allman, and M. P. Cancro
Expression of the Bcl-2 family member A1 is developmentally regulated in T cells
Int. Immunol.,
November 1, 1999;
11(11):
1753 - 1761.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-Y. Wang, D. C. Guttridge, M. W. Mayo, and A. S. Baldwin Jr.
NF-kappa B Induces Expression of the Bcl-2 Homologue A1/Bfl-1 To Preferentially Suppress Chemotherapy-Induced Apoptosis
Mol. Cell. Biol.,
September 1, 1999;
19(9):
5923 - 5929.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Orlofsky, R. D. Somogyi, L. M. Weiss, and M. B. Prystowsky
The Murine Antiapoptotic Protein A1 Is Induced in Inflammatory Macrophages and Constitutively Expressed in Neutrophils
J. Immunol.,
July 1, 1999;
163(1):
412 - 419.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Nieborowska-Skorska, M. A. Wasik, A. Slupianek, P. Salomoni, T. Kitamura, B. Calabretta, and T. Skorski
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J. Exp. Med.,
April 19, 1999;
189(8):
1229 - 1242.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Sevilla, C. Aperlo, V. Dulic, J. C. Chambard, C. Boutonnet, O. Pasquier, P. Pognonec, and K. E. Boulukos
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Mol. Cell. Biol.,
April 1, 1999;
19(4):
2624 - 2634.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R.-m. Lee, G. Gillet, J. Burnside, S. J. Thomas, and P. Neiman
Role of Nr13 in regulation of programmed cell death in the bursa of Fabricius
Genes & Dev.,
March 15, 1999;
13(6):
718 - 728.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
W.-X. Zong, L. C. Edelstein, C. Chen, J. Bash, and C. Gélinas
The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappa B that blocks TNFalpha -induced apoptosis
Genes & Dev.,
February 15, 1999;
13(4):
382 - 387.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. J. Grumont, I. J. Rourke, and S. Gerondakis
Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis
Genes & Dev.,
February 15, 1999;
13(4):
400 - 411.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
K. Yamashita, A. Takahashi, S. Kobayashi, H. Hirata, P. W. Mesner Jr, S. H. Kaufmann, S. Yonehara, K. Yamamoto, T. Uchiyama, and M. Sasada
Caspases Mediate Tumor Necrosis Factor-alpha -Induced Neutrophil Apoptosis and Downregulation of Reactive Oxygen Production
Blood,
January 15, 1999;
93(2):
674 - 685.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Hamasaki, F. Sendo, K. Nakayama, N. Ishida, I. Negishi, K.-i. Nakayama, and S. Hatakeyama
Accelerated Neutrophil Apoptosis in Mice Lacking A1-a, a Subtype of the bcl-2-related A1 Gene
J. Exp. Med.,
December 7, 1998;
188(11):
1985 - 1992.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Zhou, L. Qian, C. K. Bieszczad, R. Noelle, M. Binder, N. B. Levy, and R. W. Craig
Mcl-1 in Transgenic Mice Promotes Survival in a Spectrum of Hematopoietic Cell Types and Immortalization in the Myeloid Lineage
Blood,
November 1, 1998;
92(9):
3226 - 3239.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Hu, E. Yee, J. M. Harlan, F. Wong, and A. Karsan
Lipopolysaccharide Induces the Antiapoptotic Molecules, A1 and A20, in Microvascular Endothelial Cells
Blood,
October 15, 1998;
92(8):
2759 - 2765.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Shaknovich, P. L. Yeyati, S. Ivins, A. Melnick, C. Lempert, S. Waxman, A. Zelent, and J. D. Licht
The Promyelocytic Leukemia Zinc Finger Protein Affects Myeloid Cell Growth, Differentiation, and Apoptosis
Mol. Cell. Biol.,
September 1, 1998;
18(9):
5533 - 5545.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
T. Abe, Y. Hara, Y. Abe, Y. Aida, and K. Maeda
Serum or Growth Factor Deprivation Induces the Expression of Alkaline Phosphatase in Human Gingival Fibroblasts
Journal of Dental Research,
September 1, 1998;
77(9):
1700 - 1707.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J.-R. Chao, J.-M. Wang, S.-F. Lee, H.-W. Peng, Y.-H. Lin, C.-H. Chou, J.-C. Li, H.-M. Huang, C.-K. Chou, M.-L. Kuo, et al.
mcl-1 Is an Immediate-Early Gene Activated by the Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Signaling Pathway and Is One Component of the GM-CSF Viability Response
Mol. Cell. Biol.,
August 1, 1998;
18(8):
4883 - 4898.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. Haunstetter and S. Izumo
Apoptosis : Basic Mechanisms and Implications for Cardiovascular Disease
Circ. Res.,
June 15, 1998;
82(11):
1111 - 1129.
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Druilhe, M. Arock, L. Le Goff, and M. Pretolani
Human Eosinophils Express Bcl-2 Family Proteins: Modulation of Mcl-1 Expression by IFN-gamma
Am. J. Respir. Cell Mol. Biol.,
March 1, 1998;
18(3):
315 - 322.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. M. Tomayko and M. P. Cancro
Long-Lived B Cells Are Distinguished by Elevated Expression of A1
J. Immunol.,
January 1, 1998;
160(1):
107 - 111.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. M. Feldman, L. A. Rosenthal, X. Liu, M. P. Hayes, A. Wynshaw-Boris, W. J. Leonard, L. Hennighausen, and D. S. Finbloom
STAT5A-Deficient Mice Demonstrate a Defect in Granulocyte-Macrophage Colony-Stimulating Factor-Induced Proliferation and Gene Expression
Blood,
September 1, 1997;
90(5):
1768 - 1776.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Lomo, H. K. Blomhoff, S. E. Jacobsen, S. Krajewski, J. C. Reed, and E. B. Smeland
Interleukin-13 in Combination With CD40 Ligand Potently Inhibits Apoptosis in Human B Lymphocytes: Upregulation of Bcl-xL and Mcl-1
Blood,
June 15, 1997;
89(12):
4415 - 4424.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Pecci, A. Scholz, D. Pelster, and M. Beato
Progestins Prevent Apoptosis in a Rat Endometrial Cell Line and Increase the Ratio of bcl-XL to bcl-XS
J. Biol. Chem.,
May 2, 1997;
272(18):
11791 - 11798.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Karsan, E. Yee, and J. M. Harlan
Endothelial Cell Death Induced by Tumor Necrosis Factor-alpha Is Inhibited by the Bcl-2 Family Member, A1
J. Biol. Chem.,
November 1, 1996;
271(44):
27201 - 27204.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Hamilton, K. M. Miller, K. M. Helm, W. Y. Langdon, and S. M. Anderson
Suppression of Apoptosis Induced by Growth Factor Withdrawal by an Oncogenic Form of c-Cbl
J. Biol. Chem.,
March 16, 2001;
276(12):
9028 - 9037.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. J. Duriez, F. Wong, K. Dorovini-Zis, R. Shahidi, and A. Karsan
A1 Functions at the Mitochondria to Delay Endothelial Apoptosis in Response to Tumor Necrosis Factor
J. Biol. Chem.,
June 9, 2000;
275(24):
18099 - 18107.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
