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Defects in hemostasis in P-selectin-deficient mice
M Subramaniam, PS Frenette, S Saffaripour, RC Johnson, RO Hynes and DD Wagner
Center for Blood Research, Boston, MA 02115, USA.
Recently, our laboratory showed that platelets, like leukocytes, roll on
activated endothelium expressing P-selectin, thus suggesting a role for
P-selectin in hemostasis (Frenette et at, Proc Natl Acad Sci USA 92:7450,
1995). We report here that the P-selectin--deficient mice show a 40%
prolongation of the bleeding time on amputation of the tip of the tail.
Moreover, defective hemostasis was observed in a local Shwartzman- like
reaction induced by skin injections of lipopolysaccharide followed by tumor
necrosis factor-alpha in the P-selectin--deficient mice. The hemorrhagic
lesions, quantitated both macroscopically and microscopically, were twofold
larger in the P-selectin--deficient mice. This was also confirmed by
measuring the radioactivity in the skin using chromium-labeled red blood
cells. Therefore, it is evident that P- selectin plays a role in hemostasis
as suggested by its support of platelet rolling.
Volume 87,
Issue 4,
pp. 1238-1242,
02/15/1996
Copyright © 1996 by The American Society of Hematology
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