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A case of hypereosinophilic syndrome is associated with the expansion of a
CD3-CD4+ T-cell population able to secrete large amounts of interleukin-5
D Brugnoni, P Airo, G Rossi, A Bettinardi, HU Simon, L Garza, C Tosoni, R Cattaneo, K Blaser and A Tucci
Servizio di Immunologia Clinica, CONBIOTEC, III, Spedali Civili di Brescia,
Italy.
Interleukin-5 (IL-5) is the major soluble factor able to mediate
hypereosinophilia. We report a case of hypereosinophilic syndrome in which
the presence of a population of CD3-CD4+ cells able to overproduce IL-5 was
shown. The lack of CD3 and TCRAB membrane expression on otherwise
phenotypically normal mature T lymphocytes together with the absence of
detectable TCRBV mRNA and clonal rearrangement of TCRB gene suggested that
the abnormal lymphocyte population was the expression of a peripheral
T-cell lymphoma with an indolent clinical course. Peripheral blood
lymphocytes enriched in this population were able to secrete high levels of
IL-5 but not IL-4, and no IL-2 or interferon-gamma, when stimulated in
vitro with phytohemagglutinin and phorbol myristate acetate. The serum
contained eosinophil survival factors whose activity was partially
neutralized by a specific antihuman IL-5 antibody. This observation further
emphasized the relationship between hypereosinophilic syndrome. IL-5, and
T-cell lymphoproliferative disorders.
Volume 87,
Issue 4,
pp. 1416-1422,
02/15/1996
Copyright © 1996 by The American Society of Hematology
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