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Primary mediastinal (thymic) B-cell lymphoma is characterized by gains of
chromosomal material including 9p and amplification of the REL gene
S Joos, MI Otano-Joos, S Ziegler, S Bruderlein, S du Manoir, M Bentz, P Moller and P Lichter
Deutsches Krebsforschungszentrum, Abt. Organisation komplexer Genome,
Heidelberg, Germany.
Primary mediastinal (thymic) B-cell lymphoma is a high-grade non- Hodgkin's
lymphoma with unique features. By using comparative genomic hybridization
and interphase cytogenetics, 26 tumors were analyzed to identify genomic
imbalances. Gains of chromosomal material were much more frequent than
losses (110 v 10) and involved chromosomes 9p, 12q, and Xq (31% to 50%).
Interestingly, gain of Xq coincided with gain of 9p. Distinct high-level
amplifications were found in four subregions. In 2 cases, amplifications of
proto-oncogene REL were shown by filter hybridization, indicating a
possible pathogenic role of this gene. The characteristic pattern of
chromosomal imbalances distinct from other B- cell lymphomas suggests a
specific pathway of genetic changes associated with this lymphoma.
Volume 87,
Issue 4,
pp. 1571-1578,
02/15/1996
Copyright © 1996 by The American Society of Hematology
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