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 Previous Article | Table of Contents | Next Article 
Functional interaction of GATA1 with erythroid Kruppel-like factor and Sp1
at defined erythroid promoters
RC Gregory, DJ Taxman, D Seshasayee, MH Kensinger, JJ Bieker and DM Wojchowski
Department of Veterinary Science, The Pennsylvania State University,
University Park, USA.
GATA and CACC elements commonly are codistributed within the regulatory
domains of a variety of erythroid genes. Using Drosophila S2 cells, the
actions of GATA1, Sp1, and erythroid Kruppel-like factor (EKLF) at these
elements within model erythroid promoters have been assessed. For each
promoter studied (erythroid pyruvate kinase, glycophorin B, and a murine
betamaj globin-derived construct, GCT) Sp1 and EKLF each activated
transcription despite differences in CACC element sequence, orientation,
and positioning. However, GATA1 acted in apparent cooperativity with Sp1 at
the pyruvate kinase promoter; with EKLF at the betamaj globin-derived GCT
promoter; and with either Sp1 or EKLF at the glycophorin B promoter. Thus,
GATA1 may functionally interact with each of these Kruppel-like factors
depending on promoter context; and at the GCT promoter, transcriptional
activation by GATA1 and EKLF was > or = 10-fold higher than levels
attributable to additive effects. The possibility that interactions between
these activators may be direct was supported by the specific binding of
baculoviral-expressed EKLF to GATA1. This report underlines the likelihood
that discrete roles exist for Sp1 and EKLF in erythroid gene activation,
and supports a mechanism of direct cooperativity for EKLF and GATA1 as
coregulators.
Volume 87,
Issue 5,
pp. 1793-1801,
03/01/1996
Copyright © 1996 by The American Society of Hematology
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