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Cloning of mouse ptx3, a new member of the pentraxin gene family expressed
at extrahepatic sites
M Introna, VV Alles, M Castellano, G Picardi, L De Gioia, B Bottazzai, G Peri, F Breviario, M Salmona, L De Gregorio, TA Dragani, N Srinivasan, TL Blundell, TA Hamilton and A Mantovani
Istituto di Recerche Farmacologiche Mario Negri, Milano, Italy.
Pentraxins, which include C reactive protein (CRP) and serum amyloid P
component (SAP), are prototypic acute phase reactants that serve as
indicators of inflammatory reactions. Here we report genomic and cDNA
cloning of mouse ptx3 (mptx3), a member of the pentraxin gene family and
characterize its extrahepatic expression in vitro and in vivo. mptx3 is
organized into three exons on chromosome 3: the first (43 aa) and second
exon (175 aa) code for the signal peptide and for a protein portion with no
high similarity to known sequences the third (203 aa) for a domain related
to classical pentraxins, which contains the "pentraxin family signature."
Analysis of the N terminal portion predicts a predominantly alpha helical
structure, while the pentraxin domain of ptx3 is accommodated comfortably
in the tertiary structure fold of SAP. Normal and transformed fibroblasts,
undifferentiated and differentiated myoblasts, normal endothelial cells,
and mononuclear phagocytes express mptx3 mRNA and release the protein in
vitro on exposure to interleukin-1beta (IL-1beta) and tumor necrosis factor
(TNF)alpha. mptx3 was induced by bacterial lipopolysaccharide in vivo in a
variety of organs and, most strongly, in the vascular endothelium of
skeletal muscle and heart. Thus, mptx3 shows a distinct pattern of in vivo
expression indicative of a significant role in cardiovascular and
inflammatory pathology.
Volume 87,
Issue 5,
pp. 1862-1872,
03/01/1996
Copyright © 1996 by The American Society of Hematology
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292(5):
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January 1, 2006;
107(1):
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175(12):
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July 1, 2004;
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|
|
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|
|
|
|
|
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March 1, 2002;
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[Full Text]
[PDF]
|
|
|
|
|
|
|
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J. Leukoc. Biol.,
June 1, 2001;
69(6):
928 - 936.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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December 15, 2000;
96(13):
4300 - 4306.
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[PDF]
|
|
|
|
|
|
|
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August 8, 2000;
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[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
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J. Biol. Chem.,
December 26, 1997;
272(52):
32817 - 32823.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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J. Cell Biol.,
September 8, 1997;
138(5):
1117 - 1124.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Q. G. Dong, S. Bernasconi, S. Lostaglio, R. Wainstok De Calmanovici, I. Martin-Padura, F. Breviario, C. Garlanda, S. Ramponi, A. Mantovani, and A. Vecchi
A General Strategy for Isolation of Endothelial Cells From Murine Tissues : Characterization of Two Endothelial Cell Lines From the Murine Lung and Subcutaneous Sponge Implants
Arterioscler Thromb Vasc Biol,
August 1, 1997;
17(8):
1599 - 1604.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. Basile, A. Sica, E. d'Aniello, F. Breviario, G. Garrido, M. Castellano, A. Mantovani, and M. Introna
Characterization of the Promoter for the Human Long Pentraxin PTX3. ROLE OF NF-kappa B IN TUMOR NECROSIS FACTOR-alpha AND INTERLEUKIN-1beta REGULATION
J. Biol. Chem.,
March 28, 1997;
272(13):
8172 - 8178.
[Abstract]
[Full Text]
[PDF]
|
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