SEARCH:   Advanced

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Dinarello, C. Search for Related Content PubMed PubMed Citation Articles by Dinarello, C. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Biologic basis for interleukin-1 in disease CA Dinarello Department of Medicine, Tufts University, Boston, MA USA. To understand the role of the proinflammatory cytokine interleukin-1 (IL-1) in disease, investigators have studied how production of the different members of the IL-1 family is controlled, the various biologic activities of IL-1, the distinct and various functions of the IL-1 receptor (IL-1R) family, and the complexity of intracellular signaling. Mice deficient in IL-1Beta, IL-1Beta converting enzyme, and IL-1R type I have also been studied. Humans have been injected with IL- 1 (either IL-1alpha or IL-1beta) for enhancing bone marrow recovery and for cancer treatment. The IL-1-specific receptor antagonist (IL-1Ra) has also been tested in clinical trials. The topics discussed in this review include production and activities of IL-1 and IL-1Ra molecules, the effects of IL-1 on gene expression, functions of cell-bound and soluble IL-1 receptors, the importance of the IL-1R accessory protein, newly discovered signal transduction pathways, naturally occurring cytokines limiting IL-1 production or activity, the effects of blocking cyclooxygenase and nitric oxide, and the outcomes of IL-1 and IL-1 Ra in human trials. Special attention is paid to IL-1beta converting enzyme and programmed cell death. The roles of IL-1 in hematopoiesis, leukemia, atherosclerosis, and growth of solid tumors are also discussed. This is a lengthy review, with 586 citations chosen to illustrate specific areas of interest rather than a compendium of references. At the end of each section, a short commentary summarizes what the author considers established or controversial topics linking the biology of IL-1 to mechanisms of disease. Volume 87, Issue 6, pp. 2095-2147, 03/15/1996 Copyright © 1996 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. Fujisawa, S. Velichko, P. Thai, L.-Y. Hung, F. Huang, and R. Wu Regulation of Airway MUC5AC Expression by IL-1{beta} and IL-17A; the NF-{kappa}B Paradigm J. Immunol., November 15, 2009; 183(10): 6236 - 6243. [Abstract] [Full Text] [PDF] P. C. Patel, K. H. Fisher, E. C. C. Yang, C. M. Deane, and R. E. Harrison Proteomic Analysis of Microtubule-associated Proteins during Macrophage Activation Mol. Cell. Proteomics, November 1, 2009; 8(11): 2500 - 2514. [Abstract] [Full Text] [PDF] J. Pohl, B. Woodside, and G. N. Luheshi Changes in Hypothalamically Mediated Acute-Phase Inflammatory Responses to Lipopolysaccharide in Diet-Induced Obese Rats Endocrinology, November 1, 2009; 150(11): 4901 - 4910. [Abstract] [Full Text] [PDF] J. Harder, L. Franchi, R. Munoz-Planillo, J.-H. Park, T. Reimer, and G. Nunez Activation of the Nlrp3 Inflammasome by Streptococcus pyogenes Requires Streptolysin O and NF-{kappa}B Activation but Proceeds Independently of TLR Signaling and P2X7 Receptor J. Immunol., November 1, 2009; 183(9): 5823 - 5829. [Abstract] [Full Text] [PDF] A. V. Orjalo, D. Bhaumik, B. K. Gengler, G. K. Scott, and J. Campisi Cell surface-bound IL-1{alpha} is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network PNAS, October 6, 2009; 106(40): 17031 - 17036. [Abstract] [Full Text] [PDF] K. M. Kroeger, B. M. Sullivan, and R. M. Locksley IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38{alpha}-dependent pathway J. Leukoc. Biol., October 1, 2009; 86(4): 769 - 778. [Abstract] [Full Text] [PDF] L. K. Jones, K. M. O'Sullivan, T. Semple, M. P. Kuligowski, K. Fukami, F. Y. Ma, D. J. Nikolic-Paterson, S. R. Holdsworth, and A. R. Kitching IL-1RI deficiency ameliorates early experimental renal interstitial fibrosis Nephrol. Dial. Transplant., October 1, 2009; 24(10): 3024 - 3032. [Abstract] [Full Text] [PDF] J. Smolonska, C. Wijmenga, D. S. Postma, and H. M. Boezen Meta-analyses on Suspected Chronic Obstructive Pulmonary Disease Genes: A Summary of 20 Years' Research Am. J. Respir. Crit. Care Med., October 1, 2009; 180(7): 618 - 631. [Abstract] [Full Text] [PDF] Y. Carmi, E. Voronov, S. Dotan, N. Lahat, M. A. Rahat, M. Fogel, M. Huszar, M. R. White, C. A. Dinarello, and R. N. Apte The Role of Macrophage-Derived IL-1 in Induction and Maintenance of Angiogenesis J. Immunol., October 1, 2009; 183(7): 4705 - 4714. [Abstract] [Full Text] [PDF] Y. Lee, J. T. Thompson, and J. P. Vanden Heuvel 9E,11E-Conjugated Linoleic Acid Increases Expression of the Endogenous Antiinflammatory Factor, Interleukin-1 Receptor Antagonist, in RAW 264.7 Cells J. Nutr., October 1, 2009; 139(10): 1861 - 1866. [Abstract] [Full Text] [PDF] K. L. Hailey, S. Li, M. D. Andersen, M. Roy, V. L. Woods Jr, and P. A. Jennings Pro-interleukin (IL)-1{beta} Shares a Core Region of Stability as Compared with Mature IL-1{beta} While Maintaining a Distinctly Different Configurational Landscape: A COMPARATIVE HYDROGEN/DEUTERIUM EXCHANGE MASS SPECTROMETRY STUDY J. Biol. Chem., September 18, 2009; 284(38): 26137 - 26148. [Abstract] [Full Text] [PDF] S. SOLOVIEVA, O.-P. KAMARAINEN, A. HIRVONEN, S. HAMALAINEN, M. LAITALA, T. VEHMAS, K. LUOMA, A. NAKKI, H. RIIHIMAKI, L. ALA-KOKKO, et al. Association Between Interleukin 1 Gene Cluster Polymorphisms and Bilateral Distal Interphalangeal Osteoarthritis J Rheumatol, September 1, 2009; 36(9): 1977 - 1986. [Abstract] [Full Text] [PDF] N. A. Turner, A. Das, P. Warburton, D. J. O'Regan, S. G. Ball, and K. E. Porter Interleukin-1{alpha} stimulates proinflammatory cytokine expression in human cardiac myofibroblasts Am J Physiol Heart Circ Physiol, September 1, 2009; 297(3): H1117 - H1127. [Abstract] [Full Text] [PDF] J. A. Ehses, G. Lacraz, M.-H. Giroix, F. Schmidlin, J. Coulaud, N. Kassis, J.-C. Irminger, M. Kergoat, B. Portha, F. Homo-Delarche, et al. IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat PNAS, August 18, 2009; 106(33): 13998 - 14003. [Abstract] [Full Text] [PDF] Q. Espinassous, E. Garcia-de-Paco, I. Garcia-Verdugo, M. Synguelakis, S. von Aulock, J.-M. Sallenave, A. N. J. McKenzie, and J. Kanellopoulos IL-33 Enhances Lipopolysaccharide-Induced Inflammatory Cytokine Production from Mouse Macrophages by Regulating Lipopolysaccharide Receptor Complex J. Immunol., July 15, 2009; 183(2): 1446 - 1455. [Abstract] [Full Text] [PDF] N. E. Landvik, K. Hart, V. Skaug, L. B. Stangeland, A. Haugen, and S. Zienolddiny A specific interleukin-1B haplotype correlates with high levels of IL1B mRNA in the lung and increased risk of non-small cell lung cancer Carcinogenesis, July 1, 2009; 30(7): 1186 - 1192. [Abstract] [Full Text] [PDF] I. Aksentijevich, S. L. Masters, P. J. Ferguson, P. Dancey, J. Frenkel, A. van Royen-Kerkhoff, R. Laxer, U. Tedgard, E. W. Cowen, T.-H. Pham, et al. An Autoinflammatory Disease with Deficiency of the Interleukin-1-Receptor Antagonist N. Engl. J. Med., June 4, 2009; 360(23): 2426 - 2437. [Abstract] [Full Text] [PDF] C. Cayrol and J.-P. Girard The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1 PNAS, June 2, 2009; 106(22): 9021 - 9026. [Abstract] [Full Text] [PDF] C.-Y. Li, C.-S. Chiang, M.-L. Tsai, R.-S. Hseu, W.-Y. Shu, C.-Y. Chuang, Y.-C. Sun, Y.-S. Chang, J.-G. Lin, C.-S. Chen, et al. Two-sided effect of Cordyceps sinensis on dendritic cells in different physiological stages J. Leukoc. Biol., June 1, 2009; 85(6): 987 - 995. [Abstract] [Full Text] [PDF] L Bacconnier, C Jorgensen, and S Fabre Erosive osteoarthritis of the hand: clinical experience with anakinra Ann Rheum Dis, June 1, 2009; 68(6): 1078 - 1079. [Full Text] [PDF] Y. Ueda, D. W. Cain, M. Kuraoka, M. Kondo, and G. Kelsoe IL-1R Type I-Dependent Hemopoietic Stem Cell Proliferation Is Necessary for Inflammatory Granulopoiesis and Reactive Neutrophilia J. Immunol., May 15, 2009; 182(10): 6477 - 6484. [Abstract] [Full Text] [PDF] L. Y. A. Chai, B. J. Kullberg, A. G. Vonk, A. Warris, A. Cambi, J.-P. Latge, L. A. B. Joosten, J. W. M. van der Meer, and M. G. Netea Modulation of Toll-Like Receptor 2 (TLR2) and TLR4 Responses by Aspergillus fumigatus Infect. Immun., May 1, 2009; 77(5): 2184 - 2192. [Abstract] [Full Text] [PDF] J. G. Lee and E. P. Kay Common and Distinct Pathways for Cellular Activities in FGF-2 Signaling Induced by IL-1{beta} in Corneal Endothelial Cells Invest. Ophthalmol. Vis. Sci., May 1, 2009; 50(5): 2067 - 2076. [Abstract] [Full Text] [PDF] D. Melisi, J. Niu, Z. Chang, Q. Xia, B. Peng, S. Ishiyama, D. B. Evans, and P. J. Chiao Secreted Interleukin-1{alpha} Induces a Metastatic Phenotype in Pancreatic Cancer by Sustaining a Constitutive Activation of Nuclear Factor-{kappa}B Mol. Cancer Res., May 1, 2009; 7(5): 624 - 633. [Abstract] [Full Text] [PDF] M. Elkabets, Y. Krelin, S. Dotan, A. Cerwenka, A. Porgador, R. G. Lichtenstein, M. R. White, M. Zoller, Y. Iwakura, C. A. Dinarello, et al. Host-Derived Interleukin-1{alpha} Is Important in Determining the Immunogenicity of 3-Methylcholantrene Tumor Cells J. Immunol., April 15, 2009; 182(8): 4874 - 4881. [Abstract] [Full Text] [PDF] C. Orelio, M. Peeters, E. Haak, K. van der Horn, and E. Dzierzak Interleukin-1 regulates hematopoietic progenitor and stem cells in the midgestation mouse fetal liver Haematologica, April 1, 2009; 94(4): 462 - 469. [Abstract] [Full Text] [PDF] N. Ambalavanan, W. A. Carlo, C. T. D'Angio, S. A. McDonald, A. Das, D. Schendel, P. Thorsen, R. D. Higgins, and for the Eunice Kennedy Shriver National Institute Cytokines Associated With Bronchopulmonary Dysplasia or Death in Extremely Low Birth Weight Infants Pediatrics, April 1, 2009; 123(4): 1132 - 1141. [Abstract] [Full Text] [PDF] D. D. Bannerman Pathogen-dependent induction of cytokines and other soluble inflammatory mediators during intramammary infection of dairy cows J Anim Sci, April 1, 2009; 87(13_suppl): 10 - 25. [Abstract] [Full Text] [PDF] C. A. Nold-Petry, M. F. Nold, J. A. Zepp, S.-H. Kim, N. F. Voelkel, and C. A. Dinarello IL-32-dependent effects of IL-1{beta} on endothelial cell functions PNAS, March 10, 2009; 106(10): 3883 - 3888. [Abstract] [Full Text] [PDF] A. Sassano, M. Lo Iacono, G. Antico, A. Jordan, S. Uddin, R. A. Calogero, and L. C. Platanias Regulation of leukemic cell differentiation and retinoid-induced gene expression by statins Mol. Cancer Ther., March 1, 2009; 8(3): 615 - 625. [Abstract] [Full Text] [PDF] S. L. Lebeis, K. R. Powell, D. Merlin, M. A. Sherman, and D. Kalman Interleukin-1 Receptor Signaling Protects Mice from Lethal Intestinal Damage Caused by the Attaching and Effacing Pathogen Citrobacter rodentium Infect. Immun., February 1, 2009; 77(2): 604 - 614. [Abstract] [Full Text] [PDF] J. A. Lust, M. Q. Lacy, S. R. Zeldenrust, A. Dispenzieri, M. A. Gertz, T. E. Witzig, S. Kumar, S. R. Hayman, S. J. Russell, F. K. Buadi, et al. Induction of a Chronic Disease State in Patients With Smoldering or Indolent Multiple Myeloma by Targeting Interleukin 1{beta}-Induced Interleukin 6 Production and the Myeloma Proliferative Component Mayo Clin. Proc., February 1, 2009; 84(2): 114 - 122. [Abstract] [Full Text] [PDF] E J Giamarellos-Bourboulis, M Mouktaroudi, E Bodar, J van der Ven, B-J Kullberg, M G Netea, and J W M van der Meer Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1{beta} by mononuclear cells through a caspase 1-mediated process Ann Rheum Dis, February 1, 2009; 68(2): 273 - 278. [Abstract] [Full Text] [PDF] M. Ganaiem, M. AbuElhija, E. Lunenfeld, N. Cherniy, N. Weisze, S. B.-S. Itach, H. Breitbart, R. Apte, and M. Huleihel Effect of Interleukin-1 Receptor Antagonist Gene Deletion on Male Mouse Fertility Endocrinology, January 1, 2009; 150(1): 295 - 303. [Abstract] [Full Text] [PDF] D. A. Rao, R. E. Eid, L. Qin, T. Yi, N. C. Kirkiles-Smith, G. Tellides, and J. S. Pober Interleukin (IL)-1 promotes allogeneic T cell intimal infiltration and IL-17 production in a model of human artery rejection J. Exp. Med., December 22, 2008; 205(13): 3145 - 3158. [Abstract] [Full Text] [PDF] C. Orelio, E. Haak, M. Peeters, and E. Dzierzak Interleukin-1-mediated hematopoietic cell regulation in the aorta-gonad-mesonephros region of the mouse embryo Blood, December 15, 2008; 112(13): 4895 - 4904. [Abstract] [Full Text] [PDF] K. C. Verhein, D. B. Jacoby, and A. D. Fryer IL-1 Receptors Mediate Persistent, but Not Acute, Airway Hyperreactivity to Ozone in Guinea Pigs Am. J. Respir. Cell Mol. Biol., December 1, 2008; 39(6): 730 - 738. [Abstract] [Full Text] [PDF] E S Molloy, M P Morgan, G A Doherty, B McDonnell, J O'Byrne, D J Fitzgerald, and G M McCarthy Mechanism of basic calcium phosphate crystal-stimulated matrix metalloproteinase-13 expression by osteoarthritic synovial fibroblasts: inhibition by prostaglandin E2 Ann Rheum Dis, December 1, 2008; 67(12): 1773 - 1779. [Abstract] [Full Text] [PDF] H. Sun, W.-C. Chung, S.-H. Ryu, Z. Ju, H. T. Tran, E. Kim, J. M. Kurie, and J. S. Koo Cyclic AMP-Responsive Element Binding Protein- and Nuclear Factor-{kappa}B-Regulated CXC Chemokine Gene Expression in Lung Carcinogenesis Cancer Prevention Research, October 1, 2008; 1(5): 316 - 328. [Abstract] [Full Text] [PDF] D. Zoukhri, S. Ko, P. C. Stark, and C. L. Kublin Roles of Caspase 1 and Extracellular Signal-Regulated Kinase in Inflammation-Induced Inhibition of Lacrimal Gland Protein Secretion Invest. Ophthalmol. Vis. Sci., October 1, 2008; 49(10): 4392 - 4398. [Abstract] [Full Text] [PDF] C. M. Pretto, H. P. Gaide Chevronnay, P. B. Cornet, C. Galant, D. Delvaux, P. J. Courtoy, E. Marbaix, and P. Henriet Production of Interleukin-1{alpha} by Human Endometrial Stromal Cells Is Triggered during Menses and Dysfunctional Bleeding and Is Induced in Culture by Epithelial Interleukin-1{alpha} Released upon Ovarian Steroids Withdrawal J. Clin. Endocrinol. Metab., October 1, 2008; 93(10): 4126 - 4134. [Abstract] [Full Text] [PDF] M. Boni-Schnetzler, J. Thorne, G. Parnaud, L. Marselli, J. A. Ehses, J. Kerr-Conte, F. Pattou, P. A. Halban, G. C. Weir, and M. Y. Donath Increased Interleukin (IL)-1{beta} Messenger Ribonucleic Acid Expression in {beta}-Cells of Individuals with Type 2 Diabetes and Regulation of IL-1{beta} in Human Islets by Glucose and Autostimulation J. Clin. Endocrinol. Metab., October 1, 2008; 93(10): 4065 - 4074. [Abstract] [Full Text] [PDF] D. Kafka, E. Ling, G. Feldman, D. Benharroch, E. Voronov, N. Givon-Lavi, Y. Iwakura, R. Dagan, R. N. Apte, and Y. Mizrachi-Nebenzahl Contribution of IL-1 to resistance to Streptococcus pneumoniae infection Int. Immunol., September 1, 2008; 20(9): 1139 - 1146. [Abstract] [Full Text] [PDF] H.-H. Chang, C.-B. Wu, Y.-J. Chen, C.-Y. Weng, W.-P. Wong, Y.-J. Chen, B.-E. Chang, M.-H. Chen, and C.-C.J. Yao MMP-3 Response to Compressive Forces in vitro and in vivo Journal of Dental Research, July 1, 2008; 87(7): 692 - 696. [Abstract] [Full Text] [PDF] T. Takenouchi, Y. Iwamaru, S. Sugama, M. Sato, M. Hashimoto, and H. Kitani Lysophospholipids and ATP Mutually Suppress Maturation and Release of IL-1{beta} in Mouse Microglial Cells Using a Rho-Dependent Pathway J. Immunol., June 15, 2008; 180(12): 7827 - 7839. [Abstract] [Full Text] [PDF] P. L. Podolin, B. J. Bolognese, D. C. Carpenter, T. G. Davis, R. A. Johanson, J. H. Fox, E. Long III, X. Dong, R. W. Marquis, S. M. LoCastro, et al. Inhibition of Invariant Chain Processing, Antigen-Induced Proliferative Responses, and the Development of Collagen-Induced Arthritis and Experimental Autoimmune Encephalomyelitis by a Small Molecule Cysteine Protease Inhibitor J. Immunol., June 15, 2008; 180(12): 7989 - 8003. [Abstract] [Full Text] [PDF] J. Hewinson, S. F. Moore, C. Glover, A. G. Watts, and A. B. MacKenzie A Key Role for Redox Signaling in Rapid P2X7 Receptor-Induced IL-1{beta} Processing in Human Monocytes J. Immunol., June 15, 2008; 180(12): 8410 - 8420. [Abstract] [Full Text] [PDF] C. Guruvayoorappan and G. Kuttan (+)-Catechin inhibits tumour angiogenesis and regulates the production of nitric oxide and TNF-{alpha} in LPS-stimulated macrophages Innate Immunity, June 1, 2008; 14(3): 160 - 174. [Abstract] [PDF] W. F. Fearon and D. T. Fearon Inflammation and Cardiovascular Disease: Role of the Interleukin-1 Receptor Antagonist Circulation, May 20, 2008; 117(20): 2577 - 2579. [Full Text] [PDF] D. B. Conze, C.-J. Wu, J. A. Thomas, A. Landstrom, and J. D. Ashwell Lys63-Linked Polyubiquitination of IRAK-1 Is Required for Interleukin-1 Receptor- and Toll-Like Receptor-Mediated NF-{kappa}B Activation Mol. Cell. Biol., May 15, 2008; 28(10): 3538 - 3547. [Abstract] [Full Text] [PDF] E. J. Cornish, B. J. Hurtgen, K. McInnerney, N. L. Burritt, R. M. Taylor, J. N. Jarvis, S. Y. Wang, and J. B. Burritt Reduced Nicotinamide Adenine Dinucleotide Phosphate Oxidase-Independent Resistance to Aspergillus fumigatus in Alveolar Macrophages J. Immunol., May 15, 2008; 180(10): 6854 - 6867. [Abstract] [Full Text] [PDF] M. Y. Donath, J. Storling, L. A. Berchtold, N. Billestrup, and T. Mandrup-Poulsen Cytokines and {beta}-Cell Biology: from Concept to Clinical Translation Endocr. Rev., May 1, 2008; 29(3): 334 - 350. [Abstract] [Full Text] [PDF] M. A. Eskan, M. R. Benakanakere, B. G. Rose, P. Zhang, J. Zhao, P. Stathopoulou, D. Fujioka, and D. F. Kinane Interleukin-1{beta} Modulates Proinflammatory Cytokine Production in Human Epithelial Cells Infect. Immun., May 1, 2008; 76(5): 2080 - 2089. [Abstract] [Full Text] [PDF] N. S. Sauter, F. T. Schulthess, R. Galasso, L. W. Castellani, and K. Maedler The Antiinflammatory Cytokine Interleukin-1 Receptor Antagonist Protects from High-Fat Diet-Induced Hyperglycemia Endocrinology, May 1, 2008; 149(5): 2208 - 2218. [Abstract] [Full Text] [PDF] S. Sharma, N. Kulk, M. F. Nold, R. Graf, S.-H. Kim, D. Reinhardt, C. A. Dinarello, and P. Bufler The IL-1 Family Member 7b Translocates to the Nucleus and Down-Regulates Proinflammatory Cytokines J. Immunol., April 15, 2008; 180(8): 5477 - 5482. [Abstract] [Full Text] [PDF] S. Shoma, K. Tsuchiya, I. Kawamura, T. Nomura, H. Hara, R. Uchiyama, S. Daim, and M. Mitsuyama Critical Involvement of Pneumolysin in Production of Interleukin-1{alpha} and Caspase-1-Dependent Cytokines in Infection with Streptococcus pneumoniae In Vitro: a Novel Function of Pneumolysin in Caspase-1 Activation Infect. Immun., April 1, 2008; 76(4): 1547 - 1557. [Abstract] [Full Text] [PDF] C. Pfleger, H. B. Mortensen, L. Hansen, C. Herder, B. O. Roep, H. Hoey, H.-J. Aanstoot, M. Kocova, N. C. Schloot, and on behalf of the Hvidore Study Group on Childhood Association of IL-1ra and Adiponectin With C-Peptide and Remission in Patients With Type 1 Diabetes Diabetes, April 1, 2008; 57(4): 929 - 937. [Abstract] [Full Text] [PDF] S. Bozza, T. Zelante, S. Moretti, P. Bonifazi, A. DeLuca, C. D'Angelo, G. Giovannini, C. Garlanda, L. Boon, F. Bistoni, et al. Lack of Toll IL-1R8 Exacerbates Th17 Cell Responses in Fungal Infection J. Immunol., March 15, 2008; 180(6): 4022 - 4031. [Abstract] [Full Text] [PDF] N. Marina-Garcia, L. Franchi, Y.-G. Kim, D. Miller, C. McDonald, G.-J. Boons, and G. Nunez Pannexin-1-Mediated Intracellular Delivery of Muramyl Dipeptide Induces Caspase-1 Activation via Cryopyrin/NLRP3 Independently of Nod2 J. Immunol., March 15, 2008; 180(6): 4050 - 4057. [Abstract] [Full Text] [PDF] R. Manzer, C. A. Dinarello, G. McConville, and R. J. Mason Ozone Exposure of Macrophages Induces an Alveolar Epithelial Chemokine Response through IL-1{alpha} Am. J. Respir. Cell Mol. Biol., March 1, 2008; 38(3): 318 - 323. [Abstract] [Full Text] [PDF] J. Zabaleta, H.-Y. Lin, R. A. Sierra, M.C. Hall, P. E. Clark, O. A. Sartor, J. J. Hu, and A. C. Ochoa Interactions of cytokine gene polymorphisms in prostate cancer risk Carcinogenesis, March 1, 2008; 29(3): 573 - 578. [Abstract] [Full Text] [PDF] N. E. Humphreys, D. Xu, M. R. Hepworth, F. Y. Liew, and R. K. Grencis IL-33, a Potent Inducer of Adaptive Immunity to Intestinal Nematodes J. Immunol., February 15, 2008; 180(4): 2443 - 2449. [Abstract] [Full Text] [PDF] J A Frank, J-F Pittet, C Wray, and M A Matthay Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade Thorax, February 1, 2008; 63(2): 147 - 153. [Abstract] [Full Text] [PDF] J. W. Koo and R. S. Duman IL-1 is an essential mediator of the antineurogenic and anhedonic effects of stress PNAS, January 15, 2008; 105(2): 751 - 756. [Abstract] [Full Text] [PDF] S. Schmidt, T. H. Westhoff, P. Krauser, W. Zidek, and M. van der Giet The uraemic toxin phenylacetic acid increases the formation of reactive oxygen species in vascular smooth muscle cells Nephrol. Dial. Transplant., January 1, 2008; 23(1): 65 - 71. [Abstract] [Full Text] [PDF] K. Enya, H. Hayashi, T. Takii, N. Ohoka, S. Kanata, T. Okamoto, and K. Onozaki The interaction with Sp1 and reduction in the activity of histone deacetylase 1 are critical for the constitutive gene expression of IL-1{alpha} in human melanoma cells J. Leukoc. Biol., January 1, 2008; 83(1): 190 - 199. [Abstract] [Full Text] [PDF] C. Guruvayoorappan and G. Kuttan Apoptotic Effect of Biophytum sensitivum on B16F-10 Cells and Its Regulatory Effects on Nitric Oxide and Cytokine Production on Tumor-Associated Macrophages Integr Cancer Ther, December 1, 2007; 6(4): 373 - 380. [Abstract] [PDF] D. A. Rao, K. J. Tracey, and J. S. Pober IL-1{alpha} and IL-1beta Are Endogenous Mediators Linking Cell Injury to the Adaptive Alloimmune Response J. Immunol., November 15, 2007; 179(10): 6536 - 6546. [Abstract] [Full Text] [PDF] L. S. Miller, E. M. Pietras, L. H. Uricchio, K. Hirano, S. Rao, H. Lin, R. M. O'Connell, Y. Iwakura, A. L. Cheung, G. Cheng, et al. Inflammasome-Mediated Production of IL-1beta Is Required for Neutrophil Recruitment against Staphylococcus aureus In Vivo J. Immunol., November 15, 2007; 179(10): 6933 - 6942. [Abstract] [Full Text] [PDF] S. Hong, A. Brass, M. Seman, F. Haag, F. Koch-Nolte, and G. R. Dubyak Lipopolysaccharide, IFN-{gamma}, and IFN-beta Induce Expression of the Thiol-Sensitive ART2.1 Ecto-ADP-Ribosyltransferase in Murine Macrophages J. Immunol., November 1, 2007; 179(9): 6215 - 6227. [Abstract] [Full Text] [PDF] S. K. Bunt, L. Yang, P. Sinha, V. K. Clements, J. Leips, and S. Ostrand-Rosenberg Reduced Inflammation in the Tumor Microenvironment Delays the Accumulation of Myeloid-Derived Suppressor Cells and Limits Tumor Progression Cancer Res., October 15, 2007; 67(20): 10019 - 10026. [Abstract] [Full Text] [PDF] M. Loiarro, F. Capolunghi, N. Fanto, G. Gallo, S. Campo, B. Arseni, R. Carsetti, P. Carminati, R. De Santis, V. Ruggiero, et al. Pivotal Advance: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound J. Leukoc. Biol., October 1, 2007; 82(4): 801 - 810. [Abstract] [Full Text] [PDF] J. F. Di Mari, J. I. Saada, R. C. Mifflin, J. D. Valentich, and D. W. Powell HETEs enhance IL-1-mediated COX-2 expression via augmentation of message stability in human colonic myofibroblasts Am J Physiol Gastrointest Liver Physiol, October 1, 2007; 293(4): G719 - G728. [Abstract] [Full Text] [PDF] N. A. Turner, R. S. Mughal, P. Warburton, D. J. O'Regan, S. G. Ball, and K. E. Porter Mechanism of TNF{alpha}-induced IL-1{alpha}, IL-1{beta} and IL-6 expression in human cardiac fibroblasts: Effects of statins and thiazolidinediones Cardiovasc Res, October 1, 2007; 76(1): 81 - 90. [Abstract] [Full Text] [PDF] X. Zhu, Y. Lin, M. Bacanamwo, L. Chang, R. Chai, I. Massud, J. Zhang, M. T. Garcia-Barrio, W. E. Thompson, and Y. E. Chen Interleukin-1 {beta}-induced Id2 gene expression is mediated by Egr-1 in vascular smooth muscle cells Cardiovasc Res, October 1, 2007; 76(1): 141 - 148. [Abstract] [Full Text] [PDF] H. Hayakawa, M. Hayakawa, A. Kume, and S.-i. Tominaga Soluble ST2 Blocks Interleukin-33 Signaling in Allergic Airway Inflammation J. Biol. Chem., September 7, 2007; 282(36): 26369 - 26380. [Abstract] [Full Text] [PDF] C. Guruvayoorappan and G. Kuttan {beta}-Carotene Inhibits Tumor-Specific Angiogenesis by Altering the Cytokine Profile and Inhibits the Nuclear Translocation of Transcription Factors in B16F-10 Melanoma Cells Integr Cancer Ther, September 1, 2007; 6(3): 258 - 270. [Abstract] [PDF] H. Tohyama, K. Yasuda, H. Uchida, and J. Nishihira The responses of extrinsic fibroblasts infiltrating the devitalised patellar tendon to IL-1{beta} are different from those of normal tendon fibroblasts J Bone Joint Surg Br, September 1, 2007; 89-B(9): 1261 - 1267. [Abstract] [Full Text] [PDF] C. Brikos, R. Wait, S. Begum, L. A. J. O'Neill, and J. Saklatvala Mass Spectrometric Analysis of the Endogenous Type I Interleukin-1 (IL-1) Receptor Signaling Complex Formed after IL-1 Binding Identifies IL-1RAcP, MyD88, and IRAK-4 as the Stable Components Mol. Cell. Proteomics, September 1, 2007; 6(9): 1551 - 1559. [Abstract] [Full Text] [PDF] C. Garlanda, D. Di Liberto, A. Vecchi, M. P. La Manna, C. Buracchi, N. Caccamo, A. Salerno, F. Dieli, and A. Mantovani Damping Excessive Inflammation and Tissue Damage in Mycobacterium tuberculosis Infection by Toll IL-1 Receptor 8/Single Ig IL-1-Related Receptor, a Negative Regulator of IL-1/TLR Signaling J. Immunol., September 1, 2007; 179(5): 3119 - 3125. [Abstract] [Full Text] [PDF] M. M. Markiewski and J. D. Lambris The Role of Complement in Inflammatory Diseases From Behind the Scenes into the Spotlight Am. J. Pathol., September 1, 2007; 171(3): 715 - 727. [Abstract] [Full Text] [PDF] S. Nakao, Y. Hata, M. Miura, K. Noda, Y. N. Kimura, S. Kawahara, T. Kita, T. Hisatomi, T. Nakazawa, Y. Jin, et al. Dexamethasone Inhibits Interleukin-1{beta}-Induced Corneal Neovascularization: Role of Nuclear Factor-{kappa}B-Activated Stromal Cells in Inflammatory Angiogenesis Am. J. Pathol., September 1, 2007; 171(3): 1058 - 1065. [Abstract] [Full Text] [PDF] J. T. Soller, H. M. Escobar, S. Willenbrock, M. Janssen, N. Eberle, J. Bullerdiek, and I. Nolte Comparison of the Human and Canine Cytokines IL-1({alpha}/{beta}) and TNF-{alpha} to Orthologous Other Mammalians J. Hered., August 3, 2007; (2007) esm025v3. [Abstract] [Full Text] [PDF] Y. Qu, L. Franchi, G. Nunez, and G. R. Dubyak Nonclassical IL-1beta Secretion Stimulated by P2X7 Receptors Is Dependent on Inflammasome Activation and Correlated with Exosome Release in Murine Macrophages J. Immunol., August 1, 2007; 179(3): 1913 - 1925. [Abstract] [Full Text] [PDF] J. Shen, D. K. Arnett, J. M. Peacock, L. D. Parnell, A. Kraja, J. E. Hixson, M. Y. Tsai, C.-Q. Lai, E. K. Kabagambe, R. J. Straka, et al. Interleukin1{beta} Genetic Polymorphisms Interact with Polyunsaturated Fatty Acids to Modulate Risk of the Metabolic Syndrome J. Nutr., August 1, 2007; 137(8): 1846 - 1851. [Abstract] [Full Text] [PDF] A. S. Nayak, C. R. Lage, and C. H. Kim Effects of Low Concentrations of Arsenic on the Innate Immune System of the Zebrafish (Danio Rerio) Toxicol. Sci., July 1, 2007; 98(1): 118 - 124. [Abstract] [Full Text] [PDF] C. Guruvayoorappan and G. Kuttan Effect of Amentoflavone on the Inhibition of Pulmonary Metastasis Induced by B16F-10 Melanoma Cells in C57BL/6 Mice Integr Cancer Ther, June 1, 2007; 6(2): 185 - 197. [Abstract] [PDF] J. Yang, X. Liao, M. K. Agarwal, L. Barnes, P. E. Auron, and G. R. Stark Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NF{kappa}B Genes & Dev., June 1, 2007; 21(11): 1396 - 1408. [Abstract] [Full Text] [PDF] K. Schultz, V. Murthy, J. B. Tatro, and D. Beasley Endogenous interleukin-1{alpha} promotes a proliferative and proinflammatory phenotype in human vascular smooth muscle cells Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2927 - H2934. [Abstract] [Full Text] [PDF] C.-F. Flach, F. Qadri, T. R. Bhuiyan, N. H. Alam, E. Jennische, I. Lonnroth, and J. Holmgren Broad Up-Regulation of Innate Defense Factors during Acute Cholera Infect. Immun., May 1, 2007; 75(5): 2343 - 2350. [Abstract] [Full Text] [PDF]

	Copyright © 1996 by American Society of Hematology         Online ISSN: 1528-0020