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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Alexander, W. Articles by Metcalf, D Search for Related Content PubMed PubMed Citation Articles by Alexander, W. Articles by Metcalf, D Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl WS Alexander, AW Roberts, NA Nicola, R Li and D Metcalf The Walter and Eliza Hall Institute for Medical Research, Royal Melbourne Hospital, Victoria, Australia. Mice with a null mutation in the thrombopoietin (TPO) receptor c-Mpl were generated by gene targeting. c-mpl-deficient mice developed normally but were deficient in megakaryocytes and severely thrombocytopenic. The hematocrit and numbers of mature circulating leukocytes were normal in mpl-/- mice, as was the distribution of morphologically identifiable precursors in hematopoietic tissues. Bone marrow and spleen cells of adult mpl-/- mice lacked specific binding sites for TPO, were unresponsive to TPO in culture, and displayed a marked deficiency in progenitor cells with megakaryocytic potential. Significantly, total hematopoietic progenitor cell numbers were also reduced in mpl-/- mice including multipotential, blast cell, and committed progenitors of multiple lineages. The megakaryocyte deficiency was evident as early as 14 days of gestation in mpl- deficient mice, although reductions in progenitor cell numbers arose only later in development. The data suggest that the critical function of c-Mpl signalling in megakaryocytopoiesis is in maintenance of mature megakaryocyte numbers through control of progenitor cell proliferation and maturation. Moreover, our results also imply an important role for TPO and c-Mpl in the production of primitive pluripotent progenitor cells as well as progenitor cells committed to nonmegakaryocytic lineages. Volume 87, Issue 6, pp. 2162-2170, 03/15/1996 Copyright © 1996 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. O. Lee, J. M. Davidson, and R. J. Duronio Endoreplication: polyploidy with purpose Genes & Dev., November 1, 2009; 23(21): 2461 - 2477. [Abstract] [Full Text] [PDF] E. A. Kruse, S. J. Loughran, T. M. Baldwin, E. C. Josefsson, S. Ellis, D. K. Watson, P. Nurden, D. Metcalf, D. J. Hilton, W. S. Alexander, et al. 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