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Mutations in the Wilms' tumor gene WT1 in leukemias
L King-Underwood, J Renshaw and K Pritchard-Jones
Institute of Cancer Research, Sutton, Surrey, UK.
The tissue-specific Wilms' tumor gene WT1 is expressed in a range of acute
leukemias and hematopoietic cell lines. Using single-strand conformational
polymorphism analysis, we have found mutations in the WT1 gene in 4 of 36
acute leukemias. WT1 mutations are found in 15% of cases of acute myeloid
leukemia, in which they are associated with a poor response to
chemotherapy. The mutations comprise small insertions in exons 1 and 7 and
a nonsense mutation in exon 9. All are predicted to produce a truncated WT1
protein with absence or disruption of the zinc finger region. These are the
first mutations in the WT1 gene to be described in sporadic leukemia.
Volume 87,
Issue 6,
pp. 2171-2179,
03/15/1996
Copyright © 1996 by The American Society of Hematology
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