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Eosinophils express a functional receptor for interferon alpha: inhibitory
role of interferon alpha on the release of mediators
D Aldebert, B Lamkhioued, C Desaint, AS Gounni, M Goldman, A Capron, L Prin and M Capron
Centre d'Immunologie et de Biologie Parasitaire, Unite INSERM U167,
Institut Pasteur, Lille, France.
Recent reports describe the beneficial use of alpha interferon (IFNalpha)
for the treatment of idiopathic hypereosinophilic syndrome (HES)
unresponsive to conventional therapy. A clinical improvement associated
with a rapid decrease of peripheral blood eosinophilia suggested possible
direct effects of IFNalpha on eosinophils through the presence of IFNalpha
receptors (IFNalphaR). Reverse transcriptase- polymerase chain reaction
(RT-PCR) and cytochemistry were used respectively to detect the presence
and define the distribution of IFNalphaR on enriched eosinophil
preparations purified from blood cells. IFNalphaR was found on eosinophils
collected from patients with various eosinophilic disorders. In addition,
IFNalpha inhibited the release of eosinophil granule proteins such as
eosinophil cationic protein (ECP), neurotoxin (EDN, or interleukin-5
(IL-5). Moreover, antiparasite cytotoxicity was also strongly reduced in a
dose-dependent manner by IFNalpha. These results provide the first evidence
that human eosinophils express a functional receptor for IFNalpha and
represent a potential basis for the beneficial effects of IFNalpha in
patients with hypereosinophilic syndromes.
Volume 87,
Issue 6,
pp. 2354-2360,
03/15/1996
Copyright © 1996 by The American Society of Hematology
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