|
|
 Previous Article | Table of Contents | Next Article 
Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in
cultured endothelial cells
A Karsan, E Yee, K Kaushansky and JM Harlan
Department of Medicine, Division of Hematology, University of Washington,
Seattle, 98195, USA.
Bcl-2 is an intracellular membrane-associated protein that functions to
block programmed cell death. Despite recurrent exposure to cellular toxins
from the circulation and tissue, endothelial cells are remarkably resistant
to cell death. Because Bcl-2 protein levels are low or undetectable in
endothelial cells, we postulated that other members of the growing Bcl-2
family would be present in endothelial cells to provide protection against
apoptosis. Degenerate primers to two conserved regions of the Bcl-2 family
were used to amplify potential homologues in endothelial cells. This
strategy resulted in the isolation of a human Bcl-2 homologue related to
murine Al, a recently identified member of this family. We show here that,
in endothelial cells, human Al is rapidly inducible by phorbol ester and
the inflammatory cytokines, tumor necrosis factor-alpha and interleukin-
1beta, but not by the growth factors, basic fibroblast growth factor or
vascular endothelial growth factor. Al is the only known Bcl-2 family
member that is inducible by inflammatory cytokines, suggesting that it may
play a protective role during inflammation. Additionally, vascular smooth
muscle cells and various nonhematopoietic tissues express human Al,
indicating that human Al is a widely expressed Bcl-2 homologue.
Volume 87,
Issue 8,
pp. 3089-3096,
04/15/1996
Copyright © 1996 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
B. D. Zeitlin, I. J. Zeitlin, and J. E. Nor
Expanding Circle of Inhibition: Small-Molecule Inhibitors of Bcl-2 as Anticancer Cell and Antiangiogenic Agents
J. Clin. Oncol.,
September 1, 2008;
26(25):
4180 - 4188.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Ulleras, M. Karlberg, C. Moller Westerberg, J. Alfredsson, S. Gerondakis, A. Strasser, and G. Nilsson
NFAT but not NF-{kappa}B is critical for transcriptional induction of the prosurvival gene A1 after IgE receptor activation in mast cells
Blood,
March 15, 2008;
111(6):
3081 - 3089.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. M. Pegman, S. M. Smith, B. N. D'Souza, S. T. Loughran, S. Maier, B. Kempkes, P. A. Cahill, M. J. Simmons, C. Gelinas, and D. Walls
Epstein-Barr Virus Nuclear Antigen 2 trans-Activates the Cellular Antiapoptotic bfl-1 Gene by a CBF1/RBPJ{kappa}-Dependent Pathway.
J. Virol.,
August 1, 2006;
80(16):
8133 - 8144.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Ushizawa, T. Takahashi, K. Kaneyama, M. Hosoe, and K. Hashizume
Cloning of the Bovine Antiapoptotic Regulator, BCL2-Related Protein A1, and Its Expression in Trophoblastic Binucleate Cells of Bovine Placenta
Biol Reprod,
February 1, 2006;
74(2):
344 - 351.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. M. Kloosterboer, S. A. P. van Luxemburg-Heijs, R. A. van Soest, H. M. E. van Egmond, R. Willemze, and J. H. F. Falkenburg
Up-regulated expression in nonhematopoietic tissues of the BCL2A1-derived minor histocompatibility antigens in response to inflammatory cytokines: relevance for allogeneic immunotherapy of leukemia
Blood,
December 1, 2005;
106(12):
3955 - 3957.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Liu, H.-W. Peng, Y.-S. Cheng, H. S. Yuan, and H.-F. Yang-Yen
Stabilization and Enhancement of the Antiapoptotic Activity of Mcl-1 by TCTP
Mol. Cell. Biol.,
April 15, 2005;
25(8):
3117 - 3126.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Karsan, I. Pollet, L.-R. Yu, K. C. Chan, T. P. Conrads, D. A. Lucas, R. Andersen, and T. Veenstra
Quantitative Proteomic Analysis of Sokotrasterol Sulfate-stimulated Primary Human Endothelial Cells
Mol. Cell. Proteomics,
February 1, 2005;
4(2):
191 - 204.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. N. D'Souza, L. C. Edelstein, P. M. Pegman, S. M. Smith, S. T. Loughran, A. Clarke, A. Mehl, M. Rowe, C. Gelinas, and D. Walls
Nuclear Factor {kappa}B-Dependent Activation of the Antiapoptotic bfl-1 Gene by the Epstein-Barr Virus Latent Membrane Protein 1 and Activated CD40 Receptor
J. Virol.,
February 15, 2004;
78(4):
1800 - 1816.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. D. Bannerman and S. E. Goldblum
Mechanisms of bacterial lipopolysaccharide-induced endothelial apoptosis
Am J Physiol Lung Cell Mol Physiol,
June 1, 2003;
284(6):
L899 - L914.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. C. Edelstein, L. Lagos, M. Simmons, H. Tirumalai, and C. Gelinas
NF-{kappa}B-Dependent Assembly of an Enhanceosome-Like Complex on the Promoter Region of Apoptosis Inhibitor Bfl-1/A1
Mol. Cell. Biol.,
April 15, 2003;
23(8):
2749 - 2761.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. B. Werner, E. de Vries, S. W. G. Tait, I. Bontjer, and J. Borst
Bcl-2 Family Member Bfl-1/A1 Sequesters Truncated Bid to Inhibit Its Collaboration with Pro-apoptotic Bak or Bax
J. Biol. Chem.,
June 14, 2002;
277(25):
22781 - 22788.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. I. Chuang, S. Morefield, C.-Y. Liu, S. Chen, J. M. Harlan, and D. M. Willerford
Perturbation of B-cell development in mice overexpressing the Bcl-2 homolog A1
Blood,
May 1, 2002;
99(9):
3350 - 3359.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Ha, S. Lee, M. Chung, and Y. Choi
Mouse ING1 Homologue, a Protein Interacting with A1, Enhances Cell Death and Is Inhibited by A1 in Mammary Epithelial Cells
Cancer Res.,
March 1, 2002;
62(5):
1275 - 1278.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Xiang, A. A. Ahmed, C. Moller, K.-i. Nakayama, S. Hatakeyama, and G. Nilsson
Essential Role of the Prosurvival bcl-2 Homologue A1 in Mast Cell Survival After Allergic Activation
J. Exp. Med.,
November 26, 2001;
194(11):
1561 - 1570.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. H. J. M. PIJPERS, P. A. V. SETTEN, L. P. W. J. V. D. HEUVEL, K. J. M. ASSMANN, H. B. P. M. DIJKMAN, A. H. M. PENNINGS, L. A. H. MONNENS, and V. W. M. V. HINSBERGH
Verocytotoxin-Induced Apoptosis of Human Microvascular Endothelial Cells
J. Am. Soc. Nephrol.,
April 1, 2001;
12(4):
767 - 778.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kausalya, R. Somogyi, A. Orlofsky, and M. B. Prystowsky
Requirement of A1-a for Bacillus Calmette-Guerin-Mediated Protection of Macrophages Against Nitric Oxide-Induced Apoptosis
J. Immunol.,
April 1, 2001;
166(7):
4721 - 4727.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. S. Moreb, J. Zucali, M. Konopleva, Z. Xie, S. Zhao, and M. Andreeff
Human A1 expression in acute myeloid leukemia and its relationship to Bcl-2 expression
Blood,
January 15, 2001;
97(2):
578 - 579.
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. D'Souza, M. Rowe, and D. Walls
The bfl-1 Gene Is Transcriptionally Upregulated by the Epstein-Barr Virus LMP1, and Its Expression Promotes the Survival of a Burkitt's Lymphoma Cell Line
J. Virol.,
July 15, 2000;
74(14):
6652 - 6658.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
T. L. Horn, T. D. O'Brien, L. B. Schook, and M. S. Rutherford
Acute Hepatotoxicant Exposure Induces TNFR-Mediated Hepatic Injury and Cytokine/Apoptotic Gene Expression
Toxicol. Sci.,
March 1, 2000;
54(1):
262 - 273.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Gotoh, K. Kambara, X.-W. Jiang, M. Ohno, S. Emura, T. Fujiwara, and H. Fujiwara
Apoptosis in microvascular endothelial cells of perfused rabbit lungs with acute hydrostatic edema
J Appl Physiol,
February 1, 2000;
88(2):
518 - 526.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Zen, A. Karsan, A. Stempien-Otero, E. Yee, J. Tupper, X. Li, T. Eunson, M. A. Kay, C. B. Wilson, R. K. Winn, et al.
NF-kappa B Activation Is Required for Human Endothelial Survival during Exposure to Tumor Necrosis Factor-alpha but Not to Interleukin-1beta or Lipopolysaccharide
J. Biol. Chem.,
October 1, 1999;
274(40):
28808 - 28815.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-Y. Wang, D. C. Guttridge, M. W. Mayo, and A. S. Baldwin Jr.
NF-kappa B Induces Expression of the Bcl-2 Homologue A1/Bfl-1 To Preferentially Suppress Chemotherapy-Induced Apoptosis
Mol. Cell. Biol.,
September 1, 1999;
19(9):
5923 - 5929.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. H. Lee, H. Dadgostar, Q. Cheng, J. Shu, and G. Cheng
NF-kappa B-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes
PNAS,
August 3, 1999;
96(16):
9136 - 9141.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Stroka, A. Z. Badrichani, F. H. Bach, and C. Ferran
Overexpression of A1, an NF-kappa B-Inducible Anti-Apoptotic Bcl Gene, Inhibits Endothelial Cell Activation
Blood,
June 1, 1999;
93(11):
3803 - 3810.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. J. Ackermann, J. K. Taylor, R. Narayana, and C. F. Bennett
The Role of Antiapoptotic Bcl-2 Family Members in Endothelial Apoptosis Elucidated with Antisense Oligonucleotides
J. Biol. Chem.,
April 16, 1999;
274(16):
11245 - 11252.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R.-m. Lee, G. Gillet, J. Burnside, S. J. Thomas, and P. Neiman
Role of Nr13 in regulation of programmed cell death in the bursa of Fabricius
Genes & Dev.,
March 15, 1999;
13(6):
718 - 728.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
O. MEILHAC, I. ESCARGUEIL-BLANC, J.-C. THIERS, R. SALVAYRE, and A. NÈGRE-SALVAYRE
Bcl-2 alters the balance between apoptosis and necrosis, but does not prevent cell death induced by oxidized low density lipoproteins
FASEB J,
March 1, 1999;
13(3):
485 - 494.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
W.-X. Zong, L. C. Edelstein, C. Chen, J. Bash, and C. Gélinas
The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappa B that blocks TNFalpha -induced apoptosis
Genes & Dev.,
February 15, 1999;
13(4):
382 - 387.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. J. Grumont, I. J. Rourke, and S. Gerondakis
Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis
Genes & Dev.,
February 15, 1999;
13(4):
400 - 411.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
K. E. Noble, R. G. Wickremasinghe, C. DeCornet, P. Panayiotidis, and K. L. Yong
Monocytes Stimulate Expression of the Bcl-2 Family Member, A1, in Endothelial Cells and Confer Protection Against Apoptosis
J. Immunol.,
February 1, 1999;
162(3):
1376 - 1383.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Hamasaki, F. Sendo, K. Nakayama, N. Ishida, I. Negishi, K.-i. Nakayama, and S. Hatakeyama
Accelerated Neutrophil Apoptosis in Mice Lacking A1-a, a Subtype of the bcl-2-related A1 Gene
J. Exp. Med.,
December 7, 1998;
188(11):
1985 - 1992.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. P. Perera and T. A. Waldmann
Activation of human monocytes induces differential resistance to apoptosis with rapid down regulation of caspase-8/FLICE
PNAS,
November 24, 1998;
95(24):
14308 - 14313.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Hu, E. Yee, J. M. Harlan, F. Wong, and A. Karsan
Lipopolysaccharide Induces the Antiapoptotic Molecules, A1 and A20, in Microvascular Endothelial Cells
Blood,
October 15, 1998;
92(8):
2759 - 2765.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Dibbert, I. Daigle, D. Braun, C. Schranz, M. Weber, K. Blaser, U. Zangemeister-Wittke, A. N. Akbar, and H.-U. Simon
Role for Bcl-xL in Delayed Eosinophil Apoptosis Mediated by Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-5
Blood,
August 1, 1998;
92(3):
778 - 783.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Stehlik, R. de Martin, I. Kumabashiri, J. A. Schmid, B. R. Binder, and J. Lipp
Nuclear Factor (NF)-{kappa}B-regulated X-chromosome-linked iap Gene Expression Protects Endothelial Cells from Tumor Necrosis Factor {alpha}-induced Apoptosis
J. Exp. Med.,
July 1, 1998;
188(1):
211 - 216.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.-P. Gerber, V. Dixit, and N. Ferrara
Vascular Endothelial Growth Factor Induces Expression of the Antiapoptotic Proteins Bcl-2 and A1 in Vascular Endothelial Cells
J. Biol. Chem.,
May 22, 1998;
273(21):
13313 - 13316.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Scatena, M. Almeida, M. L. Chaisson, N. Fausto, R. F. Nicosia, and C. M. Giachelli
NF-{kappa}B Mediates {alpha}v{beta}3 Integrin-induced Endothelial Cell Survival
J. Cell Biol.,
May 18, 1998;
141(4):
1083 - 1093.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. T Colston, B. Chandrasekar, and G. L Freeman
Expression of apoptosis-related proteins in experimental coxsackievirus myocarditis
Cardiovasc Res,
April 1, 1998;
38(1):
158 - 168.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Druilhe, M. Arock, L. Le Goff, and M. Pretolani
Human Eosinophils Express Bcl-2 Family Proteins: Modulation of Mcl-1 Expression by IFN-gamma
Am. J. Respir. Cell Mol. Biol.,
March 1, 1998;
18(3):
315 - 322.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
D. Mitra, E. A. Jaffe, B. Weksler, K. A. Hajjar, C. Soderland, and J. Laurence
Thrombotic Thrombocytopenic Purpura and Sporadic Hemolytic-Uremic Syndrome Plasmas Induce Apoptosis in Restricted Lineages of Human Microvascular Endothelial Cells
Blood,
February 15, 1997;
89(4):
1224 - 1234.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Karsan, E. Yee, and J. M. Harlan
Endothelial Cell Death Induced by Tumor Necrosis Factor-alpha Is Inhibited by the Bcl-2 Family Member, A1
J. Biol. Chem.,
November 1, 1996;
271(44):
27201 - 27204.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. E. Joyce, L. Gelbert, A. Ciaccia, B. DeHoff, and B. W. Grinnell
Gene Expression Profile of Antithrombotic Protein C Defines New Mechanisms Modulating Inflammation and Apoptosis
J. Biol. Chem.,
March 30, 2001;
276(14):
11199 - 11203.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Shiffman, T. Mikita, J. T. N. Tai, D. P. Wade, J. G. Porter, J. J. Seilhamer, R. Somogyi, S. Liang, and R. M. Lawn
Large Scale Gene Expression Analysis of Cholesterol-loaded Macrophages
J. Biol. Chem.,
November 22, 2000;
275(48):
37324 - 37332.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. J. Duriez, F. Wong, K. Dorovini-Zis, R. Shahidi, and A. Karsan
A1 Functions at the Mitochondria to Delay Endothelial Apoptosis in Response to Tumor Necrosis Factor
J. Biol. Chem.,
June 9, 2000;
275(24):
18099 - 18107.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
