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Hematopoietic progenitors and interleukin-3-dependent cell lines synthesize
histamine in response to calcium ionophore
M Dy, A Arnould, FM Lemoine, F Machavoine, H Ziltener and E Schneider
CNRS URA 1461, Universite Rene Descartes-Paris V, Hopital Necker, France.
The calcium ionophore A23187 promotes histamine synthesis in murine bone
marrow cells by increasing the expression of mRNA encoding histidine
decarboxylase (HDC), the histamine-forming enzyme. The cells responsible
for this biological activity copurify with hematopoietic progenitors in
terms of density, light scatter characteristics, and rhodamine retention,
similar to interleukin (IL) 3-induced histamine- producing cells. Yet, the
effect of calcium ionophore is not mediated by IL-3. The most purified
rhodamine-bright bone marrow subset contains 80% cells that respond to
calcium ionophore by increased HDC mRNA expression. This high frequency
makes the involvement of one particular progenitor subset in histamine
synthesis unlikely. The finding that all IL-3-dependent cell lines tested
so far exhibit increased histamine production and HDC mRNA expression in
response to calcium influx lends further support to this notion. Cell lines
requiring other growth factors or proliferating spontaneously lack this
ability. Finally, it should be noted that IL-3-dependent cell lines do not
produce histamine in response to their growth factor. It might, therefore,
be suggested that the pathway transducing the signal for increased
histamine synthesis after IL-3 receptor binding in normal hematopoietic
progenitors is modified in these cell lines.
Volume 87,
Issue 8,
pp. 3161-3169,
04/15/1996
Copyright © 1996 by The American Society of Hematology
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