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Increased soluble interleukin-1 type II receptor concentrations in
postoperative patients and in patients with sepsis syndrome
JH Pruitt, MB Welborn, PD Edwards, TR Harward, JW Seeger, TD Martin, C Smith, JA Kenney, RI Wesdorp, S Meijer, MA Cuesta, A Abouhanze, EM Copeland , J Giri, JE Sims, LL Moldawer and HS Oldenburg
Department Surgery, University of Florida College of Medicine, Gainesville;
USA.
Plasma interleukin-1 (IL-1) activity is modulated in part through the
simultaneous appearance of several inhibitors of IL-1 action, including
interleukin-1 receptor antagonist (IL-1ra) and the soluble IL-1 type II
receptor (IL-1RII). However, little is known concerning the plasma
appearance of these inhibitors in patients following operative trauma or
those with sepsis syndrome. In the present report, plasma IL-1beta, IL-1ra,
and soluble IL-1RI and IL-1RII concentrations were evaluated in 118
patients with sepsis syndrome or after elective operative trauma. Plasma
concentrations of IL-1ra increased significantly following elective
operative repair of thoraco-abdominal and abdominal aortic aneurysms, and
after bowel resection for inflammatory bowel disease, but did not increase
after laparoscopic cholecystectomy. Plasma IL-1ra levels were also elevated
in patients with sepsis syndrome. In contrast, soluble IL-1RII levels were
only increased in patients after operative repair of thoraco-abdominal
aortic aneurysms and in sepsis syndrome, whereas concentrations were
unaffected by the other more modest surgical procedures. Plasma IL-1RI
concentrations decreased in all postoperative patients in the first 24
hours after surgery. We conclude that both plasma IL-1ra and soluble
IL-1RII concentrations often increase in sepsis and following some
operative trauma. Less severe operative trauma increases the plasma
concentration of only IL- 1ra, whereas both IL-1ra and soluble IL-1RII are
increased in patients with sepsis syndrome or following thoraco-abdominal
aneurysm repair.
Volume 87,
Issue 8,
pp. 3282-3288,
04/15/1996
Copyright © 1996 by The American Society of Hematology
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