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Clonal populations of CD4+ and CD8+ T cells in patients with multiple
myeloma and paraproteinemia
P Moss, G Gillespie, P Frodsham, J Bell and H Reyburn
Department of Haematology, Institute of Molecular Medicine, The Churchill
Radcliffe Hospital, Headington, Oxford, UK.
Patients with paraproteinemia have abnormalities in their T-cell subsets
including inversion of the CD4:CD8 ratio and increased expression of
activation markers. Recently, distortions in T-cell receptor (TCR) TCRAV
and TCRBV gene segment expression have been reported, although the
significance of these observations is unclear given the finding of clonal
populations of CD8+ T cells in healthy elderly individuals. We have used an
extensive range of TCR V-region- specific monoclonal antibodies to assess
TCRAV and TCRBV expression in patients with myeloma and paraproteinemia.
TCR sequence analysis was used to assess the clonality of expansions and
3-color fluorescence- activated cell sorting analysis determined the
phenotype of the expanded populations. The patients show novel oligoclonal
expansions within the CD4+ subset and show an increased frequency of CD8+
expansions. Oligoclonal CD4+ T cells belong to the rare CD4+CD28- T- cell
subset, a phenotype associated with granular morphology. CD45RA and CD11b
are expressed on many of the CD8 T-cell expansions. Comparison of T-cell
receptor sequences from two T-cell clones in one patient suggests a
possible role for a common peptide antigen in the generation of the
expansions. Further work is needed to identify the relevance of such T
cells to the B-cell proliferation.
Volume 87,
Issue 8,
pp. 3297-3306,
04/15/1996
Copyright © 1996 by The American Society of Hematology
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