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Cross-linking CD7 on myeloblasts results in granulocyte-macrophage
colony-stimulating factor production
Z Hou, E Leta and LK Jung
Department of Pediatrics, University of Massachusetts Medical Center,
Worcester, USA.
CD7+CD34+ lymphohematopoietic progenitor cells in bone marrow are capable
of differentiating into either lymphocytes or myeloid cells. The mechanism
whereby these bipotent progenitor cells are regulated is not yet clear. In
this study, we investigated the role CD7 may play in the development of
bipotent cells using two myeloid progenitor cell lines, KG-1 and KG-1a, as
models for such cells. Our data showed that cross-linking CD7 on KG-1 and
KG-1a cells induced transcription, translation, and secretion of
granulocyte-macrophage colony-stimulating factor (GM-CSF). Anti-CD7
antibody also augmented the colony formation by KG-1 cells. Protein
synthesis in KG-1 cells also increased as a result of anti-CD7 stimulation.
These phenomena could be blocked by anti-GM-CSF, and supported the notion
that the secreted GM-CSF was the primary mediator of CD7 effects. Together,
these findings suggest that the interaction between CD7 and its putative
ligand may play an important role in hematopoietic development.
Volume 88,
Issue 1,
pp. 124-129,
07/01/1996
Copyright © 1996 by The American Society of Hematology
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