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Favored use of immunoglobulin V(H)4 Genes in AIDS-associated B-cell
lymphoma
A Bessudo, V Cherepakhin, TA Johnson, LZ Rassenti, E Feigal and TJ Kipps
Department of Medicine, University of California at San Diego, La Jolla,
92093-0663, USA.
We examined the lg heavy chain variable region genes (Ig V(H) genes)
expressed in biopsy specimens of 10 patients with acquired immunodeficiency
syndrome (AIDS)-associated lymphoma. Eight expressed Ig V(H) genes of the
V(H)4 group, indicating a bias toward expression of Ig V(H) genes of this
subgroup. Sequence analyses of Ig V(H) genes isolated from any one lymphoma
did not reveal evidence for intraclonal diversity. However, some lymphomas
express Ig V(H) genes that apparently have undergone somatic
diversification and selection. In addition, we found that the sequence
encoding each examined third complementarity determining region most likely
resulted from D-D fusion, a process that ordinarily contributes to the
generation of a relatively small proportion of the Ig heavy chain genes
expressed by normal adult B cells. The noted restriction in the use of Ig
V(H) genes by AIDS-associated B-cell lymphomas suggests that antigenic
stimulation contributes to lymphomagenesis in patients with AIDS.
Volume 88,
Issue 1,
pp. 252-260,
07/01/1996
Copyright © 1996 by The American Society of Hematology
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