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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Poort, S. Articles by Bertina, R. Search for Related Content PubMed PubMed Citation Articles by Poort, S. Articles by Bertina, R. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis SR Poort, FR Rosendaal, PH Reitsma and RM Bertina Hemostasis and Thrombosis Research Center, Leiden University Hospital, The Netherlands. We have examined the prothrombin gene as a candidate gene for venous thrombosis in selected patients with a documented familial history of venous thrombophilia. All the exons and the 5'- and 3'-UT region of the prothrombin gene were analyzed by polymerase chain reaction and direct sequencing in 28 probands. Except for known polymorphic sites, no deviations were found in the coding regions and the 5'-UT region. Only one nucleotide change (a G to A transition) at position 20210 was identified in the sequence of the 3'-UT region. Eighteen percent of the patients had the 20210 AG genotype, as compared with 1% of a group of healthy controls (100 subjects). In a population-based case-control study, the 20210 A allele was identified as a common allele (allele frequency, 1.2%; 95% confidence interval, 0.5% to 1.8%), which increased the risk of venous thrombosis almost threefold odds ratio, 2.8; 95% confidence interval, 1.4 to 5.6. The risk of thrombosis increased for all ages and both sexes. An association was found between the presence of the 20210 A allele and elevated prothrombin levels. Most individuals (87%) with the 20210 A allele are in the highest quartile of plasma prothrombin levels (> 1.15 U/mL). Elevated prothrombin itself also was found to be a risk factor for venous thrombosis. Volume 88, Issue 10, pp. 3698-3703, 11/15/1996 Copyright © 1996 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. Sipahi, S. Karademir, A. Kuybulu, and N. Akar Diffuse Cerebral Infarct Associated With Factor V Leiden and Prothrombin 20210A Mutations in a Patient With Tetralogy of Fallot Clinical and Applied Thrombosis/Hemostasis, December 1, 2009; 15(6): 705 - 707. [Abstract] [PDF] J.C. Knight Genetics and the general physician: insights, applications and future challenges QJM, November 1, 2009; 102(11): 757 - 772. [Abstract] [Full Text] [PDF] J. C McCann and B. 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Issever Hereditary Thrombophilic Risk Factors and Venous Thromboembolism in Istanbul, Turkey: The Role in Different Clinical Manifestations of Venous Thromboembolism Clinical and Applied Thrombosis/Hemostasis, April 1, 2008; 14(2): 168 - 173. [Abstract] [PDF] K. Ghosh, S. Shetty, S. Vora, and V. Salvi Successful Pregnancy Outcome in Women With Bad Obstetric History and Recurrent Fetal Loss Due to Thrombophilia: Effect of Unfractionated Heparin and Low--Molecular Weight Heparin Clinical and Applied Thrombosis/Hemostasis, April 1, 2008; 14(2): 174 - 179. [Abstract] [PDF] C. Bauer, Z. Vichova, P. Ffrench, C. Hercule, O. Jegaden, O. Bastien, and J.-J. Lehot Extracorporeal Membrane Oxygenation with Danaparoid Sodium After Massive Pulmonary Embolism Anesth. Analg., April 1, 2008; 106(4): 1101 - 1103. [Abstract] [Full Text] [PDF] I. D. Bezemer, L. A. Bare, C. J. M. Doggen, A. R. Arellano, C. Tong, C. M. Rowland, J. Catanese, B. A. Young, P. H. Reitsma, J. J. Devlin, et al. Gene Variants Associated With Deep Vein Thrombosis JAMA, March 19, 2008; 299(11): 1306 - 1314. [Abstract] [Full Text] [PDF] S. Tran, E. Norstrom, and B. Dahlback Effects of Prothrombin on the Individual Activated Protein C-mediated Cleavages of Coagulation Factor Va J. Biol. Chem., March 14, 2008; 283(11): 6648 - 6655. [Abstract] [Full Text] [PDF] E. M. Wysokinska, W. E. Wysokinski, R. D. Brown, K. Karnicki, I. Gosk-Beirska, D. Grill, and R. D. McBane II Thrombophilia differences in cerebral venous sinus and lower extremity deep venous thrombosis Neurology, February 19, 2008; 70(8): 627 - 633. [Abstract] [Full Text] [PDF] P. Raivio, J. Petaja, A. Kuitunen, and R. Lassila Thrombophilic Variables Do Not Increase the Generation or Procoagulant Activity of Thrombin During Cardiopulmonary Bypass Ann. Thorac. Surg., February 1, 2008; 85(2): 536 - 542. [Abstract] [Full Text] [PDF] S. Standridge and E. de los Reyes Inflammatory Bowel Disease and Cerebrovascular Arterial and Venous Thromboembolic Events in 4 Pediatric Patients: A Case Series and Review of the Literature J Child Neurol, January 1, 2008; 23(1): 59 - 66. [Abstract] [PDF] L. Raffini Thrombophilia in Children: Who to Test, How, When, and Why? Hematology, January 1, 2008; 2008(1): 228 - 235. [Abstract] [Full Text] [PDF] N. A. Goldenberg Thrombophilia States and Markers of Coagulation Activation in the Prediction of Pediatric Venous Thromboembolic Outcomes: A Comparative Analysis with Respect to Adult Evidence Hematology, January 1, 2008; 2008(1): 236 - 244. [Abstract] [Full Text] [PDF] J. Dubois MD MSc, F. Rypens MD, L. Garel MD, M. David MD, J. Lacroix MD, and F. Gauvin MD MSc Incidence of deep vein thrombosis related to peripherally inserted central catheters in children and adolescents Can. Med. Assoc. J., November 6, 2007; 177(10): 1185 - 1190. [Abstract] [Full Text] [PDF] B. Dolek, S. Eraslan, S. Eroglu, B. E. Kesim, T. Ulutin, A. Yalciner, Y. R. Laleli, and N. Gozukirmizi Molecular Analysis of Factor V Leiden, Factor V Hong Kong, Factor II G20210A, Methylenetetrahydrofolate Reductase C677T, and A1298C Mutations Related to Turkish Thrombosis Patients Clinical and Applied Thrombosis/Hemostasis, October 1, 2007; 13(4): 435 - 438. [Abstract] [PDF] M. E. Stone, S. H. Silverman, and K. Nomoto Intracardiac Thrombosis and Acute Right Ventricular Failure Following Complex Reoperative Cardiac Surgery With Aprotinin and Deep Hypothermic Circulatory Arrest Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2007; 11(3): 177 - 184. [Abstract] [PDF] F. Passamonti, M. L. Randi, E. Rumi, E. Pungolino, C. Elena, D. Pietra, M. Scapin, L. Arcaini, F. Tezza, R. Moratti, et al. Increased risk of pregnancy complications in patients with essential thrombocythemia carrying the JAK2 (617V>F) mutation Blood, July 15, 2007; 110(2): 485 - 489. [Abstract] [Full Text] [PDF] Z. Touma, S. Atweh, L. Kibbi, and T. Arayssi Longitudinal myelitis in patient with systemic lupus erythematosus, homozygous prothrombin G20210A and heterozygous MTHFR 677T Lupus, July 1, 2007; 16(7): 517 - 520. [Abstract] [PDF] A. C. Morrison, L. A. Bare, L. E. Chambless, S. G. Ellis, M. Malloy, J. P. Kane, J. S. Pankow, J. J. Devlin, J. T. Willerson, and E. Boerwinkle Prediction of Coronary Heart Disease Risk using a Genetic Risk Score: The Atherosclerosis Risk in Communities Study Am. J. Epidemiol., July 1, 2007; 166(1): 28 - 35. [Abstract] [Full Text] [PDF] D. Colaizzo, L. Amitrano, L. Iannaccone, P. Vergura, F. Cappucci, E. Grandone, M. A. Guardascione, and M. Margaglione Gain-of-function gene mutations and venous thromboembolism: distinct roles in different clinical settings J. Med. Genet., June 1, 2007; 44(6): 412 - 416. [Abstract] [Full Text] [PDF] K. R. Viel, D. K. Machiah, D. M. Warren, M. Khachidze, A. Buil, K. Fernstrom, J. C. Souto, J. M. Peralta, T. Smith, J. Blangero, et al. A sequence variation scan of the coagulation factor VIII (FVIII) structural gene and associations with plasma FVIII activity levels Blood, May 1, 2007; 109(9): 3713 - 3724. [Abstract] [Full Text] [PDF] E. Ozyurek, G. Balta, A. Degerliyurt, H. Parlak, S. Aysun, and A. Gurgey Significance of Factor V, Prothrombin, MTHFR, and PAI-1 Genotypes in Childhood Cerebral Thrombosis Clinical and Applied Thrombosis/Hemostasis, April 1, 2007; 13(2): 154 - 160. [Abstract] [PDF] S. Kabukcu, N. Keskin, A. Keskin, and E. Atalay The Frequency of Factor V Leiden and Concomitance of Factor V Leiden With Prothrombin G20210A Mutation and Methylene Tetrahydrofolate Reductase C677T Gene Mutation in Healthy Population of Denizli, Aegean Region of Turkey Clinical and Applied Thrombosis/Hemostasis, April 1, 2007; 13(2): 166 - 171. [Abstract] [PDF] D. Eterovic, M. Titlic, V. Culic, R. Zadro, and D. Primorac Lower Contribution of Factor V Leiden or G202104 Mutations to Ischemic Stroke in Patients With Clinical Risk Factors: Pair-Matched Case-Control Study Clinical and Applied Thrombosis/Hemostasis, April 1, 2007; 13(2): 188 - 193. [Abstract] [PDF] O. Hudaoglu, S. Kurul, U. Yis, E. Dirik, H. Cakmakci, and S. Men Basilar Artery Thrombosis in a Child Heterozygous for Prothrombin Gene G20210A Mutation J Child Neurol, March 1, 2007; 22(3): 329 - 331. [Abstract] [PDF] E. Berge, K. B. F. Haug, E. Charlotte Sandset, K. Kristine Haugbro, M. Turkovic, and P. M. Sandset The Factor V Leiden, Prothrombin Gene 20210GA, Methylenetetrahydrofolate Reductase 677CT and Platelet Glycoprotein IIIa 1565TC Mutations in Patients With Acute Ischemic Stroke and Atrial Fibrillation Stroke, March 1, 2007; 38(3): 1069 - 1071. [Abstract] [Full Text] [PDF] N. L. Smith, L. A. Hindorff, S. R. Heckbert, R. N. Lemaitre, K. D. Marciante, K. Rice, T. Lumley, J. C. Bis, K. L. Wiggins, F. R. Rosendaal, et al. Association of Genetic Variations With Nonfatal Venous Thrombosis in Postmenopausal Women JAMA, February 7, 2007; 297(5): 489 - 498. [Abstract] [Full Text] [PDF] N. Akar, B. Donmez, and G. Deda FXIII Gene Val34Leu Polymorphism in Turkish Children with Cerebral Infarct J Child Neurol, February 1, 2007; 22(2): 222 - 224. [Abstract] [PDF] K. Vanschoonbeek, M. A. H. Feijge, W. H. M. Saris, M. P. M. de Maat, and J. W. M. Heemskerk Plasma Triacylglycerol and Coagulation Factor Concentrations Predict the Anticoagulant Effect of Dietary Fish Oil in Overweight Subjects J. Nutr., January 1, 2007; 137(1): 7 - 13. [Abstract] [Full Text] [PDF] S. T. Morozowich, B. S. Donahue, and I. J. Welsby Genetics of coagulation: considerations for cardiac surgery. Seminars in Cardiothoracic and Vascular Anesthesia, December 1, 2006; 10(4): 297 - 313. [Abstract] [PDF] N. L. Smith, S. R. Heckbert, R. N. Lemaitre, A. P. Reiner, T. Lumley, F. R. Rosendaal, and B. M. Psaty Conjugated Equine Estrogen, Esterified Estrogen, Prothrombotic Variants, and the Risk of Venous Thrombosis in Postmenopausal Women Arterioscler Thromb Vasc Biol, December 1, 2006; 26(12): 2807 - 2812. [Abstract] [Full Text] [PDF] B. R. Hairston, M. D. P. Davis, M. R. Pittelkow, and I. Ahmed Livedoid vasculopathy: further evidence for procoagulant pathogenesis. Arch Dermatol, November 1, 2006; 142(11): 1413 - 1418. [Abstract] [Full Text] [PDF] G. Palareti, B. Cosmi, C. Legnani, A. Tosetto, C. Brusi, A. Iorio, V. Pengo, A. Ghirarduzzi, C. Pattacini, S. Testa, et al. D-Dimer Testing to Determine the Duration of Anticoagulation Therapy N. Engl. J. Med., October 26, 2006; 355(17): 1780 - 1789. [Abstract] [Full Text] [PDF] M. Coppens, M. H. van de Poel, I. Bank, K. Hamulyak, J. van der Meer, N. J. Veeger, M. H. Prins, H. R. Buller, and S. Middeldorp A prospective cohort study on the absolute incidence of venous thromboembolism and arterial cardiovascular disease in asymptomatic carriers of the prothrombin 20210A mutation Blood, October 15, 2006; 108(8): 2604 - 2607. [Abstract] [Full Text] [PDF] D. Bosler, J. Mattson, and D. Crisan Phenotypic Heterogeneity in Patients with Homozygous Prothrombin 20210AA Genotype: A Paper from the 2005 William Beaumont Hospital Symposium on Molecular Pathology J. Mol. Diagn., September 1, 2006; 8(4): 420 - 425. [Abstract] [Full Text] [PDF] B. Jilma, F. M. Kovar, G. Hron, G. Endler, C. L. Marsik, S. Eichinger, and P. A. Kyrle Homozygosity in the Single Nucleotide Polymorphism Ser128Arg in the E-Selectin Gene Associated With Recurrent Venous Thromboembolism. Arch Intern Med, August 14, 2006; 166(15): 1655 - 1659. [Abstract] [Full Text] [PDF] C. Kuhli, K. Jochmans, I. Scharrer, M. Luchtenberg, and L.-O. Hattenbach Retinal Vein Occlusion Associated With Antithrombin Deficiency Secondary to a Novel G9840C Missense Mutation. Arch Ophthalmol, August 1, 2006; 124(8): 1165 - 1169. [Abstract] [Full Text] [PDF] N. Abramson, J. P. Costantino, J. E. Garber, N. Berliner, D. L. Wickerham, and N. Wolmark Effect of Factor V Leiden and Prothrombin G20210->A Mutations on Thromboembolic Risk in the National Surgical Adjuvant Breast and Bowel Project Breast Cancer Prevention Trial. J Natl Cancer Inst, July 5, 2006; 98(13): 904 - 910. [Abstract] [Full Text] [PDF] P J D Winyard, T Bharucha, R De Bruyn, M J Dillon, W van't Hoff, R S Trompeter, R Liesner, A Wade, and L Rees Perinatal renal venous thrombosis: presenting renal length predicts outcome Arch. Dis. Child. Fetal Neonatal Ed., July 1, 2006; 91(4): F273 - F278. [Abstract] [Full Text] [PDF] A. Zivelin, R. Mor-Cohen, V. Kovalsky, N. Kornbrot, J. Conard, F. Peyvandi, P. A. Kyrle, R. Bertina, F. Peyvandi, J. Emmerich, et al. Prothrombin 20210G>A is an ancestral prothrombotic mutation that occurred in whites approximately 24 000 years ago Blood, June 15, 2006; 107(12): 4666 - 4668. [Abstract] [Full Text] [PDF] S. Jivraj, R. Rai, J. Underwood, and L. Regan Genetic thrombophilic mutations among couples with recurrent miscarriage Hum. Reprod., May 1, 2006; 21(5): 1161 - 1165. [Abstract] [Full Text] [PDF] R. L. Bick Hereditary and Acquired Thrombophilic Disorders Clinical and Applied Thrombosis/Hemostasis, April 1, 2006; 12(2): 125 - 135. [PDF] L. A. Hindorff, B. M. Psaty, C. S. Carlson, S. R. Heckbert, T. Lumley, N. L. Smith, R. N. Lemaitre, M. J. Rieder, D. A. Nickerson, and A. P. Reiner Common Genetic Variation in the Prothrombin Gene, Hormone Therapy, and Incident Nonfatal Myocardial Infarction in Postmenopausal Women Am. J. Epidemiol., April 1, 2006; 163(7): 600 - 607. [Abstract] [Full Text] [PDF] N. Hezard, L. Bouaziz-Borgi, M.-G. Remy, and P. Nguyen Utility of Thrombin-Generation Assay in the Screening of Factor V G1691A (Leiden) and Prothrombin G20210A Mutations and Protein S Deficiency Clin. Chem., April 1, 2006; 52(4): 665 - 670. [Abstract] [Full Text] [PDF] F. Dentali, M. Crowther, and W. Ageno Thrombophilic abnormalities, oral contraceptives, and risk of cerebral vein thrombosis: a meta-analysis Blood, April 1, 2006; 107(7): 2766 - 2773. [Abstract] [Full Text] [PDF] R. L. Sacco, R. Adams, G. Albers, M. J. Alberts, O. Benavente, K. Furie, L. B. Goldstein, P. Gorelick, J. Halperin, R. Harbaugh, et al. Guidelines for Prevention of Stroke in Patients With Ischemic Stroke or Transient Ischemic Attack: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association Council on Stroke: Co-Sponsored by the Council on Cardiovascular Radiology and Intervention: The American Academy of Neurology affirms the value of this guideline. Circulation, March 14, 2006; 113(10): e409 - e449. [Abstract] [Full Text] [PDF] S. Kalkanli, O. Ayyildiz, N. Tiftik, S. Batun, A. Isikdogan, H. Ince, S. Tekes, and E. Muftuoglu Factor V Leiden Mutation in Venous Thrombosis in Southeast Turkey Angiology, March 1, 2006; 57(2): 193 - 196. [Abstract] [PDF] R. L. Sacco, R. Adams, G. Albers, M. J. Alberts, O. Benavente, K. Furie, L. B. Goldstein, P. Gorelick, J. Halperin, R. Harbaugh, et al. Guidelines for Prevention of Stroke in Patients With Ischemic Stroke or Transient Ischemic Attack: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association Council on Stroke: Co-Sponsored by the Council on Cardiovascular Radiology and Intervention: The American Academy of Neurology affirms the value of this guideline. Stroke, February 1, 2006; 37(2): 577 - 617. [Abstract] [Full Text] [PDF] D. M. Monroe and M. Hoffman What Does It Take to Make the Perfect Clot? Arterioscler Thromb Vasc Biol, January 1, 2006; 26(1): 41 - 48. [Abstract] [Full Text] [PDF] R. Schneppenheim and J. Greiner Thrombosis in Infants and Children Hematology, January 1, 2006; 2006(1): 86 - 96. [Abstract] [Full Text] [PDF] S. Uitte de Willige, M. C. H. de Visser, J. J. Houwing-Duistermaat, F. R. Rosendaal, H. L. Vos, and R. M. Bertina Genetic variation in the fibrinogen gamma gene increases the risk for deep venous thrombosis by reducing plasma fibrinogen {gamma}' levels Blood, December 15, 2005; 106(13): 4176 - 4183. [Abstract] [Full Text] [PDF] G. Mello, E. Parretti, L. Marozio, C. Pizzi, A. Lojacono, T. Frusca, F. Facchinetti, and C. Benedetto Thrombophilia Is Significantly Associated With Severe Preeclampsia: Results of a Large-Scale, Case-Controlled Study Hypertension, December 1, 2005; 46(6): 1270 - 1274. [Abstract] [Full Text] [PDF] C. G. Tag, M.-C. Schifflers, M. Mohnen, A. M. Gressner, and R. Weiskirchen Atypical Melting Curve Resulting from Genetic Variation in the 3' Untranslated Region at Position 20218 in the Prothrombin Gene Analyzed with the LightCycler Factor II (Prothrombin) G20210A Assay Clin. Chem., August 1, 2005; 51(8): 1560 - 1561. [Full Text] [PDF] J. K. Lynch, C. J. Han, L. E. Nee, and K. B. Nelson Prothrombotic Factors in Children With Stroke or Porencephaly Pediatrics, August 1, 2005; 116(2): 447 - 453. [Abstract] [Full Text] [PDF] A. C.M. Jansen, E. S. van Aalst-Cohen, M. W.T. Tanck, S. Cheng, M. R. Fontecha, J. Li, J. C. Defesche, and J. J.P. Kastelein Genetic Determinants of Cardiovascular Disease Risk in Familial Hypercholesterolemia Arterioscler Thromb Vasc Biol, July 1, 2005; 25(7): 1475 - 1481. [Abstract] [Full Text] [PDF] M. Tzoufi, S. Giotopoulou, P. Papadimitriou, E. Dokou, N. I. Kolaitis, A. Siamopoulou, and G. Vartholomatos Genetic Risk Factors Associated With Thrombosis in Children With Congenital Neurologic Disorders J Child Neurol, June 1, 2005; 20(6): 509 - 512. [Abstract] [PDF] M. Tzoufi, S. Giotopoulou, P. Papadimitriou, E. Dokou, N. I. Kolaitis, A. Siamopoulou, and G. Vartholomatos Genetic Risk Factors Associated With Thrombosis in Children With Congenital Neurologic Disorders J Child Neurol, June 1, 2005; 20(6): 509 - 512. [Abstract] [PDF] S. C. Christiansen, S. C. Cannegieter, T. Koster, J. P. Vandenbroucke, and F. R. Rosendaal Thrombophilia, Clinical Factors, and Recurrent Venous Thrombotic Events JAMA, May 18, 2005; 293(19): 2352 - 2361. [Abstract] [Full Text] [PDF] S. R. Lentz Another Lesson From the Factor V Leiden Mouse: Thrombin Generation Drives Arterial Disease Circulation, April 12, 2005; 111(14): 1733 - 1734. [Full Text] [PDF] H. Stanley-Christian, A. Ghidini, R. Sacher, and M. Shemirani Fetal Genotype for Specific Inherited Thrombophilias Is Not Associated With Severe Preeclampsia Reproductive Sciences, April 1, 2005; 12(3): 198 - 201. [Abstract] [PDF] K. Saxena, M. Ranalli, N. Khan, C. Blanchong, and S. B. Kahwash Fatal Stroke in a Child with Severe Iron Deficiency Anemia and Multiple Hereditary Risk Factors for Thrombosis Clinical Pediatrics, March 1, 2005; 44(2): 175 - 180. [PDF] C. M. Johnson, L. Mureebe, and D. Silver Hypercoagulable States: A Review Vascular and Endovascular Surgery, March 1, 2005; 39(2): 123 - 133. [Abstract] [PDF] M. Sachchithananthan, S. J. Stasinopoulos, J. Wilusz, and R. L. Medcalf The relationship between the prothrombin upstream sequence element and the G20210A polymorphism: the influence of a competitive environment for mRNA 3'-end formation Nucleic Acids Res., February 17, 2005; 33(3): 1010 - 1020. [Abstract] [Full Text] [PDF] J. W. Blom, C. J. M. Doggen, S. Osanto, and F. R. Rosendaal Malignancies, Prothrombotic Mutations, and the Risk of Venous Thrombosis JAMA, February 9, 2005; 293(6): 715 - 722. [Abstract] [Full Text] [PDF] T. Lisman, P. G. de Groot, J. C.M. Meijers, and F. R. Rosendaal Reduced plasma fibrinolytic potential is a risk factor for venous thrombosis Blood, February 1, 2005; 105(3): 1102 - 1105. [Abstract] [Full Text] [PDF] R. L. Bick and D. Hoppensteadt Recurrent Miscarriage Syndrome and Infertility Due to Blood Coagulation Protein/Platelet Defects: A Review and Update Clinical and Applied Thrombosis/Hemostasis, January 1, 2005; 11(1): 1 - 13. [Abstract] [PDF] F. R. Rosendaal Venous Thrombosis: The Role of Genes, Environment, and Behavior Hematology, January 1, 2005; 2005(1): 1 - 12. [Abstract] [Full Text] [PDF] V. V. Balasa, R. A. Gruppo, C. J. Glueck, P. Wang, D. R. Roy, E. J. Wall, C. T. Mehlman, and A. H. Crawford Legg-Calve-Perthes Disease and Thrombophilia J. Bone Joint Surg. Am., December 1, 2004; 86(12): 2642 - 2647. [Abstract] [Full Text] [PDF] A. Tripodi, V. Chantarangkul, I. Martinelli, P. Bucciarelli, and P. M. Mannucci A shortened activated partial thromboplastin time is associated with the risk of venous thromboembolism Blood, December 1, 2004; 104(12): 3631 - 3634. [Abstract] [Full Text] [PDF] S. Bortolin, M. Black, H. Modi, I. Boszko, D. Kobler, D. Fieldhouse, E. Lopes, J.-M. Lacroix, R. Grimwood, P. Wells, et al. Analytical Validation of the Tag-It High-Throughput Microsphere-Based Universal Array Genotyping Platform: Application to the Multiplex Detection of a Panel of Thrombophilia-Associated Single-Nucleotide Polymorphisms Clin. Chem., November 1, 2004; 50(11): 2028 - 2036. [Abstract] [Full Text] [PDF] D Saadoun, D Cazals-Hatem, M-H Denninger, L Boudaoud, B-N Pham, V Mallet, B Condat, J Briere, and D Valla Association of idiopathic hepatic sinusoidal dilatation with the immunological features of the antiphospholipid syndrome Gut, October 1, 2004; 53(10): 1516 - 1519. [Abstract] [Full Text] [PDF] I. Bank, E. J. Libourel, S. Middeldorp, E. C. M. van Pampus, M. M. W. Koopman, K. Hamulyak, M. H. Prins, J. van der Meer, and H. R. Buller Prothrombin 20210A Mutation: A Mild Risk Factor for Venous Thromboembolism but Not for Arterial Thrombotic Disease and Pregnancy-Related Complications in a Family Study Arch Intern Med, September 27, 2004; 164(17): 1932 - 1937. [Abstract] [Full Text] [PDF] E. M. Scott, R. A.S. Ariens, and P. J. Grant Genetic and Environmental Determinants of Fibrin Structure and Function: Relevance to Clinical Disease Arterioscler Thromb Vasc Biol, September 1, 2004; 24(9): 1558 - 1566. [Abstract] [Full Text] [PDF] P. Monagle, A. Chan, P. Massicotte, E. Chalmers, and A. D. Michelson Antithrombotic Therapy in Children*: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy Chest, September 1, 2004; 126(3_suppl): 645S - 687S. [Abstract] [Full Text] [PDF]

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