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Role of granulocyte-macrophage colony-stimulating factor and granulocyte
colony-stimulating factor in the development of an acute neutrophil
inflammatory response in mice
D Metcalf, L Robb, AR Dunn, S Mifsud and L Di Rago
Walter and Eliza Hall Institute of Medical Research, Ludwig, Victoria,
Australia.
The intraperitoneal injection into mice of casein preparations containing
bacteria induced a rapid accumulation of neutrophils within 3 hours due to
selective release of mature cells from the bone marrow. Significant
increases in the concentrations of granulocyte-macrophage
colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating
factor (G-CSF) occurred in the peritoneal cavity during the process, but
the intraperitoneal injection of neither CSF induced a significant
accumulation of neutrophils and the coinjection of G-CSF and casein failed
to enhance the neutrophil response. The lack of involvement of either CSF
in the neutrophil migration was confirmed by the development of typical
neutrophil exudates when casein was injected into mice with inactivation of
the genes encoding GM-CSF, G-CSF, or the beta-common chain of the GM-CSF
receptor. However, preinjection of G-CSF increased the number of marrow
neutrophils available for migration and did result in increased numbers of
neutrophils in the peritoneal cavity after casein injection. Typical
eosinophil inflammatory responses to the injection of casein or
thioglycollate occurred in GM-CSF -/ -mice but not in beta c -/- mice,
suggesting that interleukin-5 was necessary for this response.
Volume 88,
Issue 10,
pp. 3755-3764,
11/15/1996
Copyright © 1996 by The American Society of Hematology
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